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    C18orf32 chromosome 18 open reading frame 32 [ Homo sapiens (human) ]

    Gene ID: 497661, updated on 5-Mar-2024

    Summary

    Official Symbol
    C18orf32provided by HGNC
    Official Full Name
    chromosome 18 open reading frame 32provided by HGNC
    Primary source
    HGNC:HGNC:31690
    See related
    Ensembl:ENSG00000177576 MIM:619979; AllianceGenome:HGNC:31690
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPIBD25
    Summary
    Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling. Located in endoplasmic reticulum and lipid droplet. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 45.1), kidney (RPKM 32.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See C18orf32 in Genome Data Viewer
    Location:
    18q21.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (49477243..49487234, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (49674978..49684975, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (47003613..47013604, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene dymeclin Neighboring gene uncharacterized LOC124904298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9446 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13307 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46713027-46713528 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46713529-46714028 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr18:46729371-46730248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13308 Neighboring gene NANOG hESC enhancer GRCh37_chr18:46845924-46846499 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9447 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9448 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:46991502-46992276 Neighboring gene RPL17-C18orf32 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9449 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13309 Neighboring gene proline rich 13 pseudogene 4 Neighboring gene small nucleolar RNA, C/D box 58C Neighboring gene microRNA 1539 Neighboring gene ribosomal protein L17

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    UPF0729 protein C18orf32
    Names
    putative NF-kappa-B-activating protein 200
    putative NFkB activating protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035005.4NP_001030177.1  UPF0729 protein C18orf32

      See identical proteins and their annotated locations for NP_001030177.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC100778, BC022357, BC093004, BF210402, BF512018, BP395434, CB852935
      Consensus CDS
      CCDS32831.1
      UniProtKB/Swiss-Prot
      Q8TCD1
      Related
      ENSP00000323199.3, ENST00000318240.8
      Conserved Domains (1) summary
      pfam14975
      Location:247
      DUF4512; Domain of unknown function (DUF4512)
    2. NM_001199346.2NP_001186275.1  UPF0729 protein C18orf32

      See identical proteins and their annotated locations for NP_001186275.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC100778, BC022357, BF512018, BP395434, CB852935
      Consensus CDS
      CCDS32831.1
      UniProtKB/Swiss-Prot
      Q8TCD1
      Related
      ENSP00000480941.1, ENST00000613385.4
      Conserved Domains (1) summary
      pfam14975
      Location:247
      DUF4512; Domain of unknown function (DUF4512)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      49477243..49487234 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      49674978..49684975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)