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RPL17-C18orf32 RPL17-C18orf32 readthrough [ Homo sapiens (human) ]

Gene ID: 100526842, updated on 23-Nov-2021

Summary

Official Symbol
RPL17-C18orf32provided by HGNC
Official Full Name
RPL17-C18orf32 readthroughprovided by HGNC
Primary source
HGNC:HGNC:44661
See related
Ensembl:ENSG00000215472
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PD-1; RPL17
Summary
This locus represents naturally occurring read-through transcription between the neighboring RPL17 (ribosomal protein L17) and C18orf32 (chromosome 18 open reading frame 32) genes. Alternative splicing results in multiple transcript variants. The encoded isoforms share sequence identity with the RPL17 protein, but they include frameshifted C-terminal regions derived from the downstream gene exons. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in ovary (RPKM 394.7), bone marrow (RPKM 200.0) and 25 other tissues See more
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Genomic context

See RPL17-C18orf32 in Genome Data Viewer
Location:
18q21.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (49481178..49492465, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (47007548..47018835, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene microRNA 4744 Neighboring gene dymeclin Neighboring gene proline rich 13 pseudogene 4 Neighboring gene chromosome 18 open reading frame 32 Neighboring gene small nucleolar RNA, C/D box 58C Neighboring gene small nucleolar RNA, C/D box 58A Neighboring gene small nucleolar RNA, C/D box 58B Neighboring gene long intergenic non-protein coding RNA 2837 Neighboring gene microRNA 1539 Neighboring gene signal recognition particle 72 pseudogene 1 Neighboring gene ribosomal protein L17

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
RPL17-C18orf32 protein
Names
60S ribosomal protein L17
60S ribosomal protein L23
Large ribosomal subunit protein uL22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199355.1NP_001186284.1  RPL17-C18orf32 protein isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1). The 5' UTR of this variant is incomplete due to lack of full-length transcript support for this exon combination, and the presence of ambiguous splicing in the 5' region.
    Source sequence(s)
    AC100778, BX393840
    UniProtKB/TrEMBL
    A0A0A6YYL6
    Related
    ENSP00000463379.1, ENST00000584895.5
    Conserved Domains (1) summary
    PTZ00178
    Location:1175
    PTZ00178; 60S ribosomal protein L17; Provisional
  2. NM_001199356.2NP_001186285.1  RPL17-C18orf32 protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC100778
    UniProtKB/TrEMBL
    A0A0A0MRF8
    Related
    ENSP00000352143.6, ENST00000332968.11
    Conserved Domains (1) summary
    PTZ00178
    Location:1137
    PTZ00178; 60S ribosomal protein L17; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    49481178..49492465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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