Format

Send to:

Choose Destination
    • Showing Current items.

    NRAS NRAS proto-oncogene, GTPase [ Homo sapiens (human) ]

    Gene ID: 4893, updated on 4-Oct-2020

    Summary

    Official Symbol
    NRASprovided by HGNC
    Official Full Name
    NRAS proto-oncogene, GTPaseprovided by HGNC
    Primary source
    HGNC:HGNC:7989
    See related
    Ensembl:ENSG00000213281 MIM:164790
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NS6; CMNS; NCMS; ALPS4; N-ras; NRAS1
    Summary
    This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
    Expression
    Ubiquitous expression in bone marrow (RPKM 23.0), colon (RPKM 17.3) and 25 other tissues See more
    Orthologs

    Genomic context

    See NRAS in Genome Data Viewer
    Location:
    1p13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (114704469..114716771, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (115247085..115259515, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene adenosine monophosphate deaminase 1 Neighboring gene RNA, 7SL, cytoplasmic 432, pseudogene Neighboring gene cold shock domain containing E1 Neighboring gene RNY1 pseudogene 13 Neighboring gene suppressor of IKBKE 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Colorectal cancer
    MedGen: C1527249 OMIM: 114500 GeneReviews: Lynch Syndrome
    Compare labs
    Common genetic variants on 1p13.2 associate with risk of autism.
    GeneReviews: Not available
    Epidermal nevus
    MedGen: C0334082 OMIM: 162900 GeneReviews: Not available
    Compare labs
    Epidermal nevus syndrome
    MedGen: C0265318 OMIM: 163200 GeneReviews: Not available
    Compare labs
    Follicular thyroid carcinoma
    MedGen: C4225426 OMIM: 188470 GeneReviews: Not available
    Compare labs
    Large congenital melanocytic nevus
    MedGen: C1842036 OMIM: 137550 GeneReviews: Not available
    Compare labs
    Neurocutaneous melanocytosis
    MedGen: C0544862 OMIM: 249400 GeneReviews: Not available
    Compare labs
    Noonan syndrome 6
    MedGen: C2750732 OMIM: 613224 GeneReviews: Noonan Syndrome
    Compare labs
    RAS-associated autoimmune leukoproliferative disorder
    MedGen: C2674723 OMIM: 614470 GeneReviews: Not available
    Compare labs

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of NRAS PubMed
    Knockdown of neuroblastoma RAS viral (v-ras) oncogene homolog (NRAS) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env Pretreatment of cells with HIV-1 gp160 results in marked inhibition of tyrosine phosphorylation of p59(fyn), PLC-gamma1, ras activation, and TNF-alpha secretion in anti-CD3 mAb activated CD4+ T cells PubMed
    env HIV-1 gp160 alone or CD4/gp160 cross-linking induces tyrosine phosphorylation of intracellular substrates p59fyn, zap 70, and p95vav and also leads to ras activation PubMed
    Nef nef HIV-1 Nef-induced relocalization of LCK is correlated with N-Ras activation at recycling endosome/TGN compartments PubMed
    Tat tat HIV-1 Tat activates PRKCQ (PKC-theta) kinase activity, which leads to RELA (NFkB), NRAS, RAF1, MAP2K1 (MEK1), MAP2K2 (MEK2), MAPK3 (ERK1), and MAPK1 (ERK2) activation, in Jurkat T cells that stably express Tat PubMed
    tat Treatment with Tat activates the Ras pathway in human brain micro vascular endothelial cells (HBMECs), an effect that is markedly attenuated by caveolin-1 silencing PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    MAPK cascade TAS
    Traceable Author Statement
    more info
     
    Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Ras protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Ras protein signal transduction TAS
    Traceable Author Statement
    more info
     
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    positive regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stimulatory C-type lectin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome HDA PubMed 
    membrane HDA PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    tertiary granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    GTPase NRas
    Names
    N-ras protein part 4
    neuroblastoma RAS viral (v-ras) oncogene homolog
    neuroblastoma RAS viral oncogene homolog
    transforming protein N-Ras
    v-ras neuroblastoma RAS viral oncogene homolog
    NP_002515.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007572.1 RefSeqGene

      Range
      5001..17438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_92

    mRNA and Protein(s)

    1. NM_002524.5NP_002515.1  GTPase NRas

      See identical proteins and their annotated locations for NP_002515.1

      Status: REVIEWED

      Source sequence(s)
      AL096773, AW021410, AY941101, BC005219, BC013214
      Consensus CDS
      CCDS877.1
      UniProtKB/Swiss-Prot
      P01111
      UniProtKB/TrEMBL
      Q5U091
      Related
      ENSP00000358548.4, ENST00000369535.5
      Conserved Domains (1) summary
      cd04138
      Location:3164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      114704469..114716771 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center