SLC11A2 solute carrier family 11 member 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC11A2provided by HGNC
Official Full Name: solute carrier family 11 member 2provided by HGNC
Primary source: HGNC:HGNC:10908
See related: Ensembl:ENSG00000110911 MIM:600523; AllianceGenome:HGNC:10908
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DCT1; DMT1; AHMIO1; NRAMP2
Summary: This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]
Expression: Ubiquitous expression in duodenum (RPKM 12.8), thyroid (RPKM 12.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q13.12

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (50952263..51028886, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (50915621..50992224, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (51373190..51422669, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ischemic Neuroprotection by Insulin with Down-Regulation of Divalent Metal Transporter 1 (DMT1) Expression and Ferrous Iron-Dependent Cell Death.
Title: Ischemic Neuroprotection by Insulin with Down-Regulation of Divalent Metal Transporter 1 (DMT1) Expression and Ferrous Iron-Dependent Cell Death.
DMT1-dependent endosome-mitochondria interactions regulate mitochondrial iron translocation and metastatic outgrowth.
Title: DMT1-dependent endosome-mitochondria interactions regulate mitochondrial iron translocation and metastatic outgrowth.
DMT1 differentially regulates mitochondrial complex activities to reduce glutathione loss and mitigate ferroptosis.
Title: DMT1 differentially regulates mitochondrial complex activities to reduce glutathione loss and mitigate ferroptosis.
SLC11A2: a promising biomarker and therapeutic target in ovarian cancer.
Title: SLC11A2: a promising biomarker and therapeutic target in ovarian cancer.
Genotypic Effect of IVS4+44C>A and c.2044T>C DMT1 Gene Mutations on Pathophysiology of Iron-Deficiency Anemia.
Title: Genotypic Effect of IVS4+44C>A and c.2044T>C DMT1 Gene Mutations on Pathophysiology of Iron-Deficiency Anemia.
Regulation of Iron-Ion Transporter SLC11A2 by Three Identical miRNAs.
Title: Regulation of Iron-Ion Transporter SLC11A2 by Three Identical miRNAs.
The Associations between Metalloestrogens, GSTP1, and SLC11A2 Polymorphism and the Risk of Endometrial Cancer.
Title: The Associations between Metalloestrogens, GSTP1, and SLC11A2 Polymorphism and the Risk of Endometrial Cancer.
DOES SLC11A2 GENE MUTATION ASSOCIATE WITH IRON-REFRACTORY IRON-DEFICIENCY ANEMIA AFTER BARIATRIC SURGERY?
Title: DOES SLC11A2 GENE MUTATION ASSOCIATE WITH IRON-REFRACTORY IRON-DEFICIENCY ANEMIA AFTER BARIATRIC SURGERY?
Evaluation of divalent metal transporter 1 (DMT1) (rs224589) polymorphism on blood lead levels of occupationally exposed individuals.
Title: Evaluation of divalent metal transporter 1 (DMT1) (rs224589) polymorphism on blood lead levels of occupationally exposed individuals.
Mutation analysis of seven SLC family transporters for early-onset Parkinson's disease in Chinese population.
Title: Mutation analysis of seven SLC family transporters for early-onset Parkinson's disease in Chinese population.

Submit: New GeneRIF Correction See all GeneRIFs (93)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Microcytic anemia with liver iron overload MedGen: C3806153 OMIM: 206100 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 and the viral protein Tat modulate the expression of solute carrier family 11, member 2 (SLC11A2; proton-coupled divalent metal ion transporter) in immature dendritic	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC129447P4 (e-PCR)
- UniSTS:270594

PMC129447P5 (e-PCR)
- UniSTS:270595

L18506 (e-PCR)
- UniSTS:54024

SHGC-33554 (e-PCR)
- UniSTS:70676

G20510 (e-PCR)
- UniSTS:58953

A005U25 (e-PCR)
- UniSTS:58954

WI-22218 (e-PCR)
- UniSTS:52555

RH17780 (e-PCR)
- UniSTS:16461

RH45071 (e-PCR)
- UniSTS:61016

D12S813 (e-PCR)
- UniSTS:9055

A006N48 (e-PCR)
- UniSTS:65632

RH47542 (e-PCR)
- UniSTS:65892

SHGC-35510 (e-PCR)
- UniSTS:46256

WI-11374 (e-PCR)
- UniSTS:45236

Slc11a2 (e-PCR), detects polymorphism
- UniSTS:499136

D12S1249E (e-PCR)
- UniSTS:151497

SLC11A2_739 (e-PCR)
- UniSTS:277716

D12S1402 (e-PCR)
- UniSTS:8672

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cadmium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadmium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables cadmium ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables cadmium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables calcium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables chromium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables cobalt ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables cobalt ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables cobalt ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables copper ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ferrous iron transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ferrous iron transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ferrous iron transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ferrous iron transmembrane transporter activity	NAS Non-traceable Author Statement more info	PubMed
enables inorganic cation transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables iron ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables iron ion transmembrane transporter activity	TAS Traceable Author Statement more info
enables lead ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lead ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables manganese ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables manganese ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables nickel cation transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables nickel cation transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables retromer complex binding	IDA Inferred from Direct Assay more info	PubMed
enables solute:proton symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables transition metal ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables vanadium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables zinc ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cadmium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in cobalt ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cobalt ion transport	IEA Inferred from Electronic Annotation more info
involved_in copper ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in copper ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dendrite morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in detection of oxygen	IEP Inferred from Expression Pattern more info	PubMed
NOT involved_in detection of oxygen	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within erythrocyte development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heme biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular iron ion homeostasis	TAS Traceable Author Statement more info
involved_in iron import into cell	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within iron import into cell	IEA Inferred from Electronic Annotation more info
involved_in iron import into cell	NAS Non-traceable Author Statement more info	PubMed
involved_in iron ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in iron ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in iron ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within iron ion transport	IEA Inferred from Electronic Annotation more info
involved_in iron ion transport	IEA Inferred from Electronic Annotation more info
involved_in lead ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within learning or memory	IEA Inferred from Electronic Annotation more info
involved_in manganese ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in manganese ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in manganese ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in metal ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in multicellular organismal-level iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nickel cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in nickel cation transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within porphyrin-containing compound biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within porphyrin-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to iron ion	IEP Inferred from Expression Pattern more info	PubMed
NOT involved_in response to iron ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in vanadium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in vanadium ion transport	IEA Inferred from Electronic Annotation more info
involved_in zinc ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basal part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in brush border membrane	IEA Inferred from Electronic Annotation more info
located_in brush border membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular vesicle	IEA Inferred from Electronic Annotation more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	HDA more info	PubMed
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HTP more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of paraferritin complex	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed
located_in vacuole	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: natural resistance-associated macrophage protein 2

Names: DMT-1; NRAMP 2; divalent cation transporter 1; solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_021139.1 RefSeqGene

Range

5034..53492

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1160

mRNA and Protein(s)

NM_000617.3 → NP_000608.1 natural resistance-associated macrophage protein 2 isoform 3

See identical proteins and their annotated locations for NP_000608.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct N-terminus compared to isoform 1. Variants 4, 5 and 6 encode isoform 3.

Source sequence(s)

AB004857, BC100014, DA957633

Consensus CDS

CCDS8805.1

UniProtKB/TrEMBL

A0A2R8YD71

Related

ENSP00000262052.5, ENST00000262052.9

Conserved Domains (2) summary

TIGR01197
Location:68 → 467

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

pfam01566
Location:126 → 474

Nramp; Natural resistance-associated macrophage protein
NM_001174125.2 → NP_001167596.1 natural resistance-associated macrophage protein 2 isoform 1

See identical proteins and their annotated locations for NP_001167596.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC087884, AJ493662, BC002592

Consensus CDS

CCDS53793.1

UniProtKB/TrEMBL

A0A2R8YD71

Related

ENSP00000378364.3, ENST00000394904.9

Conserved Domains (1) summary

TIGR01197
Location:97 → 496

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
NM_001174126.2 → NP_001167597.1 natural resistance-associated macrophage protein 2 isoform 2

See identical proteins and their annotated locations for NP_001167597.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and in the 3' UTR and coding region compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus and a distinct C-terminus compared to isoform 1. Isoform 2 lacks the iron responsive element (IRE) found in isoform 1. Both variants 2 and 3 encode isoform 2.

Source sequence(s)

AC087884, AF064484, DB350334

Consensus CDS

CCDS53792.1

UniProtKB/Swiss-Prot

B3KT08, B4DK84, F5H741, O43288, O60932, O94801, P49281, Q498Z5, Q8IUD7, Q96J35

UniProtKB/TrEMBL

A0A0X8GKR4, A0A2R8YD71

Related

ENSP00000494107.1, ENST00000644495.1

Conserved Domains (1) summary

TIGR01197
Location:68 → 467

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
NM_001174127.2 → NP_001167598.1 natural resistance-associated macrophage protein 2 isoform 2

See identical proteins and their annotated locations for NP_001167598.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and in the 3' UTR and coding region compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus and a distinct C-terminus compared to isoform 1. Isoform 2 lacks the iron responsive element (IRE) found in isoform 1. Both variants 2 and 3 encode isoform 2.

Source sequence(s)

AC087884

Consensus CDS

CCDS53792.1

UniProtKB/Swiss-Prot

B3KT08, B4DK84, F5H741, O43288, O60932, O94801, P49281, Q498Z5, Q8IUD7, Q96J35

UniProtKB/TrEMBL

A0A0X8GKR4, A0A2R8YD71

Related

ENSP00000446769.1, ENST00000547198.5

Conserved Domains (1) summary

TIGR01197
Location:68 → 467

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
NM_001174128.2 → NP_001167599.1 natural resistance-associated macrophage protein 2 isoform 3

See identical proteins and their annotated locations for NP_001167599.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct N-terminus compared to isoform 1. Variants 4, 5 and 6 encode isoform 3.

Source sequence(s)

AC087884, AF046997

Consensus CDS

CCDS8805.1

UniProtKB/TrEMBL

A0A2R8YD71

Conserved Domains (2) summary

TIGR01197
Location:68 → 467

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

pfam01566
Location:126 → 474

Nramp; Natural resistance-associated macrophage protein
NM_001174129.2 → NP_001167600.1 natural resistance-associated macrophage protein 2 isoform 3

See identical proteins and their annotated locations for NP_001167600.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct N-terminus compared to isoform 1. Variants 4, 5 and 6 encode isoform 3.

Source sequence(s)

AC087884

Consensus CDS

CCDS8805.1

UniProtKB/TrEMBL

A0A2R8YD71

Related

ENSP00000444542.2, ENST00000541174.6

Conserved Domains (2) summary

TIGR01197
Location:68 → 467

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

pfam01566
Location:126 → 474

Nramp; Natural resistance-associated macrophage protein
NM_001174130.2 → NP_001167601.1 natural resistance-associated macrophage protein 2 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC087884, AK316507, DC324894

Consensus CDS

CCDS53791.1

UniProtKB/TrEMBL

A0A2R8YD71

Related

ENSP00000442810.2, ENST00000545993.7

Conserved Domains (2) summary

TIGR01197
Location:64 → 463

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

pfam01566
Location:122 → 470

Nramp; Natural resistance-associated macrophage protein
NM_001379446.1 → NP_001366375.1 natural resistance-associated macrophage protein 2 isoform 5

Status: REVIEWED

Source sequence(s)

AC087884

Consensus CDS

CCDS91695.1

UniProtKB/TrEMBL

A0A2R8YD71

Related

ENSP00000449200.2, ENST00000547688.7

Conserved Domains (1) summary

TIGR01197
Location:97 → 496

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
NM_001379447.2 → NP_001366376.1 natural resistance-associated macrophage protein 2 isoform 2

Status: REVIEWED

Source sequence(s)

AC087884

Consensus CDS

CCDS53792.1

UniProtKB/Swiss-Prot

B3KT08, B4DK84, F5H741, O43288, O60932, O94801, P49281, Q498Z5, Q8IUD7, Q96J35

UniProtKB/TrEMBL

A0A0X8GKR4, A0A2R8YD71

Conserved Domains (1) summary

TIGR01197
Location:68 → 467

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
NM_001379448.1 → NP_001366377.1 natural resistance-associated macrophage protein 2 isoform 6

Status: REVIEWED

Source sequence(s)

AC087884

UniProtKB/TrEMBL

A0A2R8YD71

Conserved Domains (1) summary

TIGR01197
Location:64 → 463

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
NM_001379455.1 → NP_001366384.1 natural resistance-associated macrophage protein 2 isoform 1

Status: REVIEWED

Source sequence(s)

AC087884

Consensus CDS

CCDS53793.1

UniProtKB/TrEMBL

A0A2R8YD71

Conserved Domains (1) summary

TIGR01197
Location:97 → 496

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
NM_001414744.1 → NP_001401673.1 natural resistance-associated macrophage protein 2 isoform 3

Status: REVIEWED

Source sequence(s)

AC087884

UniProtKB/TrEMBL

A0A2R8YD71
NM_001414745.1 → NP_001401674.1 natural resistance-associated macrophage protein 2 isoform 3

Status: REVIEWED

Source sequence(s)

AC087884

UniProtKB/TrEMBL

A0A2R8YD71
NM_001414746.1 → NP_001401675.1 natural resistance-associated macrophage protein 2 isoform 3

Status: REVIEWED

Source sequence(s)

AC087884

UniProtKB/TrEMBL

A0A2R8YD71

Related

ENSP00000493633.1, ENST00000643884.1
NM_001414747.1 → NP_001401676.1 natural resistance-associated macrophage protein 2 isoform 7

Status: REVIEWED

Source sequence(s)

AC087884

UniProtKB/TrEMBL

B7Z9M2
NM_001414748.1 → NP_001401677.1 natural resistance-associated macrophage protein 2 isoform 8

Status: REVIEWED

Source sequence(s)

AC087884

UniProtKB/TrEMBL

B7Z9M2
NM_001414749.1 → NP_001401678.1 natural resistance-associated macrophage protein 2 isoform 9

Status: REVIEWED

Source sequence(s)

AC087884

UniProtKB/TrEMBL

B7Z9M2, F8W1P7

Related

ENSP00000446914.1, ENST00000546743.5
NM_001414750.1 → NP_001401679.1 natural resistance-associated macrophage protein 2 isoform 9

Status: REVIEWED

Source sequence(s)

AC087884

UniProtKB/TrEMBL

B7Z9M2, F8W1P7

RNA

NR_033421.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (8) contains an alternate 5' exon and uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC087884, AK315987, CK000292
NR_033422.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (9) contains an alternate 5' exon and uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC087884, CD365137
NR_166668.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC087884
NR_166669.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC087884
NR_166670.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC087884
NR_183175.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC087884
NR_183176.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC087884

Related

ENST00000642227.1
NR_183177.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC087884
NR_183178.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC087884
NR_183179.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC087884