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    SLC11A2 solute carrier family 11 member 2 [ Homo sapiens (human) ]

    Gene ID: 4891, updated on 8-Jul-2021

    Summary

    Official Symbol
    SLC11A2provided by HGNC
    Official Full Name
    solute carrier family 11 member 2provided by HGNC
    Primary source
    HGNC:HGNC:10908
    See related
    Ensembl:ENSG00000110911 MIM:600523
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DCT1; DMT1; AHMIO1; NRAMP2
    Summary
    This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]
    Expression
    Ubiquitous expression in duodenum (RPKM 12.8), thyroid (RPKM 12.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLC11A2 in Genome Data Viewer
    Location:
    12q13.12
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (50952263..51028886, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (51373190..51422669, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4642 Neighboring gene methyltransferase like 7A Neighboring gene HIG1 hypoxia inducible domain family member 1C Neighboring gene RNA, U7 small nuclear 39 pseudogene Neighboring gene RNA, U6 small nuclear 87, pseudogene Neighboring gene RNA, U6 small nuclear 1273, pseudogene Neighboring gene LETM1 domain containing 1 Neighboring gene cysteine and serine rich nuclear protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 and the viral protein Tat modulate the expression of solute carrier family 11, member 2 (SLC11A2; proton-coupled divalent metal ion transporter) in immature dendritic PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ37416

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cadmium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cadmium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cadmium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cadmium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cobalt ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables copper ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ferrous iron transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ferrous iron transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ferrous iron transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ferrous iron transmembrane transporter activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables iron ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables iron ion transmembrane transporter activity TAS
    Traceable Author Statement
    more info
     
    enables lead ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables lead ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables manganese ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables manganese ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nickel cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables solute:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transition metal ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cadmium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular iron ion homeostasis TAS
    Traceable Author Statement
    more info
     
    involved_in cobalt ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in copper ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in copper ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in erythrocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in iron import into cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in iron import into cell NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in iron ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in iron ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lead ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in learning or memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in manganese ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in manganese ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in multicellular organismal iron ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in multicellular organismal iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nickel cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to iron ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in apical part of cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basal part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in brush border membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosomal membrane HDA PubMed 
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of paraferritin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vacuole IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    natural resistance-associated macrophage protein 2
    Names
    DMT-1
    NRAMP 2
    divalent cation transporter 1
    solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
    solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021139.1 RefSeqGene

      Range
      5034..53492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1160

    mRNA and Protein(s)

    1. NM_000617.3NP_000608.1  natural resistance-associated macrophage protein 2 isoform 3

      See identical proteins and their annotated locations for NP_000608.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct N-terminus compared to isoform 1. Variants 4, 5 and 6 encode isoform 3.
      Source sequence(s)
      AB004857, BC100014, DA957633
      Consensus CDS
      CCDS8805.1
      UniProtKB/Swiss-Prot
      P49281
      Related
      ENSP00000262052.5, ENST00000262052.9
      Conserved Domains (2) summary
      TIGR01197
      Location:68467
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
      pfam01566
      Location:126474
      Nramp; Natural resistance-associated macrophage protein
    2. NM_001174125.2NP_001167596.1  natural resistance-associated macrophage protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001167596.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC087884, AJ493662, BC002592
      Consensus CDS
      CCDS53793.1
      UniProtKB/Swiss-Prot
      P49281
      Related
      ENSP00000378364.3, ENST00000394904.9
      Conserved Domains (1) summary
      TIGR01197
      Location:97496
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
    3. NM_001174126.2NP_001167597.1  natural resistance-associated macrophage protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001167597.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and in the 3' UTR and coding region compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus and a distinct C-terminus compared to isoform 1. Isoform 2 lacks the iron responsive element (IRE) found in isoform 1. Both variants 2 and 3 encode isoform 2.
      Source sequence(s)
      AC087884, AF064484, DB350334
      Consensus CDS
      CCDS53792.1
      UniProtKB/Swiss-Prot
      P49281
      UniProtKB/TrEMBL
      A0A0X8GKR4
      Related
      ENSP00000494107.1, ENST00000644495.1
      Conserved Domains (1) summary
      TIGR01197
      Location:68467
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
    4. NM_001174127.2NP_001167598.1  natural resistance-associated macrophage protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001167598.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and in the 3' UTR and coding region compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus and a distinct C-terminus compared to isoform 1. Isoform 2 lacks the iron responsive element (IRE) found in isoform 1. Both variants 2 and 3 encode isoform 2.
      Source sequence(s)
      AC087884
      Consensus CDS
      CCDS53792.1
      UniProtKB/Swiss-Prot
      P49281
      UniProtKB/TrEMBL
      A0A0X8GKR4
      Related
      ENSP00000446769.1, ENST00000547198.5
      Conserved Domains (1) summary
      TIGR01197
      Location:68467
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
    5. NM_001174128.2NP_001167599.1  natural resistance-associated macrophage protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001167599.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct N-terminus compared to isoform 1. Variants 4, 5 and 6 encode isoform 3.
      Source sequence(s)
      AC087884, AF046997
      Consensus CDS
      CCDS8805.1
      UniProtKB/Swiss-Prot
      P49281
      Conserved Domains (2) summary
      TIGR01197
      Location:68467
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
      pfam01566
      Location:126474
      Nramp; Natural resistance-associated macrophage protein
    6. NM_001174129.1NP_001167600.1  natural resistance-associated macrophage protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001167600.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct N-terminus compared to isoform 1. Variants 4, 5 and 6 encode isoform 3.
      Source sequence(s)
      AC087884, AK094735, DA737206
      Consensus CDS
      CCDS8805.1
      UniProtKB/Swiss-Prot
      P49281
      Related
      ENSP00000444542.2, ENST00000541174.6
      Conserved Domains (2) summary
      TIGR01197
      Location:68467
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
      pfam01566
      Location:126474
      Nramp; Natural resistance-associated macrophage protein
    7. NM_001174130.2NP_001167601.1  natural resistance-associated macrophage protein 2 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC087884, AK316507, DC324894
      Consensus CDS
      CCDS53791.1
      UniProtKB/Swiss-Prot
      P49281
      Related
      ENSP00000442810.2, ENST00000545993.7
      Conserved Domains (2) summary
      TIGR01197
      Location:64463
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
      pfam01566
      Location:122470
      Nramp; Natural resistance-associated macrophage protein
    8. NM_001379446.1NP_001366375.1  natural resistance-associated macrophage protein 2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC087884
      Related
      ENSP00000449200.2, ENST00000547688.7
      Conserved Domains (1) summary
      TIGR01197
      Location:97496
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
    9. NM_001379447.1NP_001366376.1  natural resistance-associated macrophage protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC087884
      Conserved Domains (1) summary
      TIGR01197
      Location:68467
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
    10. NM_001379448.1NP_001366377.1  natural resistance-associated macrophage protein 2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC087884
      Conserved Domains (1) summary
      TIGR01197
      Location:64463
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
    11. NM_001379455.1NP_001366384.1  natural resistance-associated macrophage protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC087884
      Conserved Domains (1) summary
      TIGR01197
      Location:97496
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

    RNA

    1. NR_033421.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) contains an alternate 5' exon and uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC087884, AK315987, CK000292
      Related
      ENST00000642227.1
    2. NR_033422.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) contains an alternate 5' exon and uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC087884, CD365137
    3. NR_166668.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884
    4. NR_166669.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884
    5. NR_166670.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      50952263..51028886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538405.3XP_011536707.1  natural resistance-associated macrophage protein 2 isoform X2

      See identical proteins and their annotated locations for XP_011536707.1

      UniProtKB/Swiss-Prot
      P49281
      UniProtKB/TrEMBL
      A0A0X8GKR4
      Related
      ENSP00000449008.1, ENST00000546636.5
      Conserved Domains (1) summary
      TIGR01197
      Location:68467
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
    2. XM_017019356.2XP_016874845.1  natural resistance-associated macrophage protein 2 isoform X4

      Related
      ENSP00000446914.1, ENST00000546743.5
      Conserved Domains (2) summary
      TIGR01197
      Location:1388
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
      pfam01566
      Location:47395
      Nramp; Natural resistance-associated macrophage protein
    3. XM_011538404.3XP_011536706.1  natural resistance-associated macrophage protein 2 isoform X2

      See identical proteins and their annotated locations for XP_011536706.1

      UniProtKB/Swiss-Prot
      P49281
      UniProtKB/TrEMBL
      A0A0X8GKR4
      Conserved Domains (1) summary
      TIGR01197
      Location:68467
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

    RNA

    1. XR_001748720.1 RNA Sequence

    2. XR_944555.1 RNA Sequence

    3. XR_429104.1 RNA Sequence

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