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    MT-ATP6 mitochondrially encoded ATP synthase 6 [ Homo sapiens (human) ]

    Gene ID: 4508, updated on 5-Aug-2022

    Summary

    Official Symbol
    MT-ATP6provided by HGNC
    Official Full Name
    mitochondrially encoded ATP synthase 6provided by HGNC
    Primary source
    HGNC:HGNC:7414
    See related
    MIM:516060; AllianceGenome:HGNC:7414
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATPase6; MTATP6; ATP6
    Summary
    Contributes to proton-transporting ATP synthase activity, rotational mechanism. Involved in mitochondrial ATP synthesis coupled proton transport. Part of mitochondrial proton-transporting ATP synthase complex. Implicated in Leber hereditary optic neuropathy; NARP syndrome; Parkinson's disease; multiple sclerosis; and systemic lupus erythematosus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See MT-ATP6 in Genome Data Viewer
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) MT (non-nuclear) NC_012920.1 (8527..9207)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) MT (non-nuclear) NC_012920.1 (8527..9207)

    Chromosome MT - NC_012920.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit II Neighboring gene tRNA-Lys Neighboring gene ATP synthase F0 subunit 8 Neighboring gene cytochrome c oxidase subunit III Neighboring gene tRNA-Gly

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in aging IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proton motive force-driven ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in proton motive force-driven ATP synthesis IC
    Inferred by Curator
    more info
    PubMed 
    involved_in proton motive force-driven mitochondrial ATP synthesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hyperoxia IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ATP synthase F0 subunit 6
    YP_003024031.1
    • ATP synthase 6; ATPase subunit 6

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_012920.1 Reference assembly

      Range
      8527..9207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_003024031.1 ATP synthase F0 subunit 6 (mitochondrion) [Homo sapiens]

      See identical proteins and their annotated locations for YP_003024031.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P00846, Q9B2Z2
      UniProtKB/TrEMBL
      Q0ZFE3
      Related
      ENSP00000354632.2
      Conserved Domains (1) summary
      MTH00101
      Location:1226
      ATP6; ATP synthase F0 subunit 6; Validated