CAPN3 calpain 3 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: CAPN3provided by CGNC
Official Full Name: calpain 3provided by CGNC
Primary source: CGNC:51929
See related: Ensembl:ENSGALG00010019472
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: p94
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	5	NC_052536.1 (25170021..25194170)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	5	NC_052577.1 (25136629..25160769)

Chromosome 5 - NC_052536.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The scaffolding protein calpain-3 has multiple distributions in embryonic chick muscle cells and it is essential for the formation of muscle fibers.
Title: The scaffolding protein calpain-3 has multiple distributions in embryonic chick muscle cells and it is essential for the formation of muscle fibers.
The present expression data of chicken CAPN3 gene may provide some information to shed light on the tissue and ontogenic expression pattern during chicken development.
Title: Characterization of the expression profile of calpain-3 (CAPN3) gene in chicken.
CAPN3 polymorphisms are strongly associated with chicken carcass traits.
Title: Identification and association of the single nucleotide polymorphisms in calpain3 (CAPN3) gene with carcass traits in chickens.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium-dependent cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: calpain-3

Names: CANP 3; calcium-activated neutral proteinase 3; calpain L3; calpain p94; muscle-specific calcium-activated neutral protease 3

NP_001004405.2

EC 3.4.22.54

XP_015142560.1

EC 3.4.22.54

XP_040556884.1

EC 3.4.22.54

XP_046774384.1

EC 3.4.22.54

XP_046774385.1

EC 3.4.22.54

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004405.3 → NP_001004405.2 calpain-3

Status: VALIDATED

Source sequence(s)

JAENSK010000214

UniProtKB/TrEMBL

A0A1D5PLJ8, B8Y8S8

Related

ENSGALP00010027940.1, ENSGALT00010047044.1

Conserved Domains (5) summary

cd00051
Location:686 → 741

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00648
Location:69 → 408

Peptidase_C2; Calpain family cysteine protease

pfam01067
Location:422 → 572

Calpain_III; Calpain large subunit, domain III

pfam13499
Location:717 → 773

EF-hand_7; EF-hand domain pair

pfam16648
Location:576 → 642

Calpain_u2; Unstructured region on Calpain-3

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

25170021..25194170

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015287074.4 → XP_015142560.1 calpain-3 isoform X1

UniProtKB/TrEMBL

A0A1L1RQ67, A0A8V0ZBA6

Related

ENSGALP00010027949.1, ENSGALT00010047063.1

Conserved Domains (4) summary

cd00051
Location:652 → 707

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00648
Location:69 → 408

Peptidase_C2; Calpain family cysteine protease

pfam01067
Location:422 → 572

Calpain_III; Calpain large subunit, domain III

pfam13499
Location:683 → 739

EF-hand_7; EF-hand domain pair
XM_040700950.1 → XP_040556884.1 calpain-3 isoform X2

Conserved Domains (4) summary

cd16190
Location:421 → 589

EFh_PEF_CAPN3; Calcium-activated neutral

pfam01067
Location:208 → 346

Calpain_III; Calpain large subunit, domain III

pfam16648
Location:355 → 421

Calpain_u2; Unstructured region on Calpain-3

cl00051
Location:1 → 187

CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.