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    Vamp7 Vesicle-associated membrane protein 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36015, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Vamp7provided by FlyBase
    Official Full Name
    Vesicle-associated membrane protein 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0266186
    Locus tag
    Dmel_CG1599
    See related
    AllianceGenome:FB:FBgn0266186
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1599; Dmel\CG1599; dVamp7; Ti-VAMP; TI-VAMP; vamp7; VAMP7; VAMP7/8; Vamp8; VAMP8
    Summary
    Enables SNAP receptor activity and SNARE binding activity. Involved in autophagosome maturation. Located in autolysosome. Part of SNARE complex. Is expressed in adult head; adult heart; and organism. Orthologous to human VAMP7 (vesicle associated membrane protein 7). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Vamp7 in Genome Data Viewer
    Location:
    46B4-46B4; 2-61 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9841080..9842502, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5728585..5730007, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene hebe Neighboring gene uncharacterized protein Neighboring gene Lsm11 Neighboring gene Mitochondrial amidoxime reducing component Neighboring gene sting Neighboring gene Proteasome alpha7 subunit Neighboring gene Origin recognition complex subunit 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionarily conserved role and physiological relevance of a STX17/Syx17 (syntaxin 17)-containing SNARE complex in autophagosome fusion with endosomes and lysosomes. Hegedűs K, et al. Autophagy, 2013 Oct. PMID 24113031
    2. The multi-functional SNARE protein Ykt6 in autophagosomal fusion processes. Kriegenburg F, et al. Cell Cycle, 2019 Mar-Apr. PMID 30836834, Free PMC Article
    3. An in vitro method for studying subcellular rearrangements during cell polarization in Drosophila melanogaster hemocytes. Edwards SS, et al. Mech Dev, 2018 Dec. PMID 30096416
    4. Longins: a new evolutionary conserved VAMP family sharing a novel SNARE domain. Filippini F, et al. Trends Biochem Sci, 2001 Jul. PMID 11440841
    5. Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators. Rossi V, et al. Trends Biochem Sci, 2004 Dec. PMID 15544955

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables SNAP receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNARE binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables syntaxin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T-tubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagosome maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosome to lysosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in secretory granule-lysosome fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SNARE complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of SNARE complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in autolysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vesicle-associated membrane protein 7
    Names
    CG1599-PA
    CG1599-PC
    Vamp7-PA
    Vamp7-PC
    vesicle-associated membrane protein 7

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9841080..9842502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136680.4 → NP_610524.1  Vesicle-associated membrane protein 7, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610524.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JYX5
      Related
      FBpp0088416
      Conserved Domains (3) summary
      cd15871
      Location:124 → 188
      R-SNARE_VAMP7; SNARE motif of VAMP7
      pfam00957
      Location:122 → 210
      Synaptobrevin; Synaptobrevin
      pfam13774
      Location:32 → 97
      Longin; Regulated-SNARE-like domain

    2. NM_001299326.1 → NP_001286255.1  Vesicle-associated membrane protein 7, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286255.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JYX5
      Conserved Domains (3) summary
      cd15871
      Location:124 → 188
      R-SNARE_VAMP7; SNARE motif of VAMP7
      pfam00957
      Location:122 → 210
      Synaptobrevin; Synaptobrevin
      pfam13774
      Location:32 → 97
      Longin; Regulated-SNARE-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JYX5 Q7JYX5

    Gene LinkOut

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