Format

Send to:

Choose Destination
    • Showing Current items.

    Plekhm1 pleckstrin homology domain containing, family M (with RUN domain) member 1 [ Mus musculus (house mouse) ]

    Gene ID: 353047, updated on 8-Jul-2021

    Summary

    Official Symbol
    Plekhm1provided by MGI
    Official Full Name
    pleckstrin homology domain containing, family M (with RUN domain) member 1provided by MGI
    Primary source
    MGI:MGI:2443207
    See related
    Ensembl:ENSMUSG00000034247
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B2; AP1; AP162; BC038943; D330036J23Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 17.4), mammary gland adult (RPKM 16.6) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Plekhm1 in Genome Data Viewer
    Location:
    11; 11 E1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (103255101..103303531, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (103364275..103412705, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (103226406..103273978, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 14 Neighboring gene predicted gene, 34823 Neighboring gene Rho GTPase activating protein 27 Neighboring gene Rho GTPase activating protein 27, opposite strand 3 Neighboring gene predicted gene, 39397 Neighboring gene leucine rich repeat containing 37A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome-lysosome fusion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in late endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lysosome localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lysosome localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ruffle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in autolysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    pleckstrin homology domain-containing family M member 1
    Names
    PH domain-containing family M member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183034.2NP_898855.1  pleckstrin homology domain-containing family M member 1

      See identical proteins and their annotated locations for NP_898855.1

      Status: VALIDATED

      Source sequence(s)
      AK048562, AL772325, BC053079, BP767414, BY203268
      Consensus CDS
      CCDS25518.1
      UniProtKB/Swiss-Prot
      Q7TSI1
      Related
      ENSMUSP00000047327.9, ENSMUST00000041272.10
      Conserved Domains (4) summary
      smart00233
      Location:703795
      PH; Pleckstrin homology domain
      cd13321
      Location:529646
      PH_PLEKHM1; Pleckstrin homology domain-containing family M member 1 Pleckstrin homology (PH) domain
      pfam02759
      Location:48181
      RUN; RUN domain
      pfam13901
      Location:8641066
      zf-RING_9; Putative zinc-RING and/or ribbon

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      103255101..103303531 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center