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    Cntln centlein, centrosomal protein [ Mus musculus (house mouse) ]

    Gene ID: 338349, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cntlnprovided by MGI
    Official Full Name
    centlein, centrosomal proteinprovided by MGI
    Primary source
    MGI:MGI:2443104
    See related
    Ensembl:ENSMUSG00000038070
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI448092; B430108F07Rik; D530005L17Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 3.3), limb E14.5 (RPKM 2.9) and 22 other tissues See more
    Orthologs

    Genomic context

    See Cntln in Genome Data Viewer
    Location:
    4; 4 C4
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (84883510..85131923)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (84530231..84777822)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene serine incorporator 3 pseudogene Neighboring gene predicted gene 12415 Neighboring gene dimethyladenosine transferase pseudogene Neighboring gene predicted gene 12419 Neighboring gene RAN, member RAS oncogene family pseudogene Neighboring gene SH3-domain GRB2-like 2 Neighboring gene phosphoglycerate mutase 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding, bridging ISO
    Inferred from Sequence Orthology
    more info
     
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    centriole-centriole cohesion ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to organelle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    centriole ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175275.4NP_780484.2  centlein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK052558, AW457797, BC089374, BM942195, CF534965, CF734586
      Consensus CDS
      CCDS51216.1
      UniProtKB/Swiss-Prot
      A2AM05
      Related
      ENSMUSP00000130491.2, ENSMUST00000169371.8
      Conserved Domains (1) summary
      TIGR02168
      Location:5231297
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    2. NM_177385.4NP_796359.1  centlein isoform 2

      See identical proteins and their annotated locations for NP_796359.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' exon structure compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK031604, AK165111, BF463497, BM942195
      Consensus CDS
      CCDS18302.1
      UniProtKB/Swiss-Prot
      A2AM05
      Related
      ENSMUSP00000099883.3, ENSMUST00000102819.9
      Conserved Domains (1) summary
      pfam08537
      Location:155248
      NBP1; Fungal Nap binding protein NBP1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      84883510..85131923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538032.3XP_006538095.1  centlein isoform X7

      Conserved Domains (1) summary
      pfam08537
      Location:155248
      NBP1; Fungal Nap binding protein NBP1
    2. XM_006538031.3XP_006538094.1  centlein isoform X6

      Conserved Domains (1) summary
      pfam08537
      Location:155248
      NBP1; Fungal Nap binding protein NBP1
    3. XM_006538028.3XP_006538091.1  centlein isoform X3

      Conserved Domains (1) summary
      COG1196
      Location:130774
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    4. XM_006538026.3XP_006538089.1  centlein isoform X1

      See identical proteins and their annotated locations for XP_006538089.1

      UniProtKB/Swiss-Prot
      A2AM05
      Related
      ENSMUSP00000044138.6, ENSMUST00000047023.12
      Conserved Domains (1) summary
      TIGR02168
      Location:5231298
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    5. XM_006538027.3XP_006538090.1  centlein isoform X2

      Conserved Domains (2) summary
      COG1196
      Location:24622
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:3691144
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    6. XM_006538029.3XP_006538092.1  centlein isoform X4

      Conserved Domains (1) summary
      TIGR02168
      Location:66841
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    7. XM_011250056.2XP_011248358.1  centlein isoform X5

      Conserved Domains (3) summary
      TIGR02168
      Location:407738
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR04211
      Location:125215
      SH3_and_anchor; SH3 domain protein
      pfam07888
      Location:24179
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like

    RNA

    1. XR_881069.2 RNA Sequence

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