Conserved Protein Domain Family
NBP1

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pfam08537: NBP1 
Fungal Nap binding protein NBP1
NBP1 is a nuclear protein which has been shown in Saccharomyces cerevisiae to be essential for the G2/M transition of the cell cycle.
Statistics
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PSSM-Id: 285709
View PSSM: pfam08537
Aligned: 12 rows
Threshold Bit Score: 284.682
Threshold Setting Gi: 1709231
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam08537 is the only member of the superfamily cl09453
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74606041    1 M-ENLKQYWNSWW---------YEND-----GRKSDkyplktrY------------------------------------ 29
gi 74693959    1 MlEPLKNIVSDFW---------LKTD-----TRKRE-------Ygsldewkqqr-------------------------- 33
gi 1709231     1 MlKSVQGLWKDFFg--------IRDD-----GRKRE-------Ygsldevrkrs-------------------------- 34
gi 74609947    1 MfETIKDLFAGVV---------TTSD-----RRKKE-------Hgsladikr---------------------------- 31
gi 254581000   1 MlESVRGFIGDILg-------yQATD-----PRKKE-------Ygslddvrtsnrq------------------------ 37
gi 363750203   1 MfQPLKDMMMDMW----------SGD-----SRKKE-------Ygsleewkqik-------------------------- 32
gi 367017224   1 MlESMKRYLGDVLg----------ND-----PRKRE-------Ygdledvrrerqe------------------------ 34
gi 156846681   1 MlDSLKGFVDDFFgkgn--qdyDEDD-----GRKRD-------Ygelselrdrrkrrravaakernrmlrmkrgdpgvad 66
gi 367005047   1 MlESVQGMARGFFg-------qDSEDrtpvdGRKHE-------Ygdleymkaqrrkrmadrsssar-------------- 52
gi 366995830   1 MlQSVQHFFTEFFnrsp--kniDNCG-----RRKKY-------Ynglkgmrrkergrsl--------------------- 45
gi 444320013   1 MfDSVQKLVTDLFnsgdnyerkHRRD-----PRKVD-------Ygnlndikarsryfpksshrpssn------------- 55
gi 410074591   1 MmKSIQAFVNDFFhn------aENED-----ERGRQarrssvvHndmgmrirkk-------------------------- 43
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74606041   30 -----------------------RGTKTS--DRYYKVQKPNTTRASRLRREPEVSEYRKPNpaen--------------- 69
gi 74693959   34 -------------gqerigrprrRASTRY--KVTKPSAVHQSALPLPVERPGAAAVRRNER------------------- 79
gi 1709231    35 --------------alrsrrkqmRPTGKSvlKRPRKVTDRKTEEKIRTNRRKtpkr------------------------ 76
gi 74609947   32 ----------------rsmnkrkRALGHN--KSITNTDQRNAEYLNKLKMRNSIRGKVGKPplrggymnsvd--ikpdtk 91
gi 254581000  38 -----------ggsgsharldrnRLRRRR--AIASNGDSANSRKYVRPQDGNRVNKMRNPSartgp-------------- 90
gi 363750203  33 --------------qndrigrprRATGRY--KVTKHSAVHKSVLPIQQNRRDGVFLKQQRQrqeqeeqrdq-----qqqq 91
gi 367017224  35 -----------rspirdrsrarvGPRSKN--RPTANFAGNGSRRMLRKERMARSNGIVKKKppvrdn------------- 88
gi 156846681  67 eiysrsrgsrvqhrsleggvhkpRNSDSA--SASSAANNYNGGTRRRQYREVSPEFVTGVPprnn--------------- 129
gi 367005047  53 -ahlmrevngnesgevllntvrnRNRGGV--KKSVNGERRKGRMYQEKVEREMLAGRIARNqrnp--------------- 114
gi 366995830  46 ---------krrsdsvlhrelypSLSSEN--KHFKTVSDPKPSRQLKT-RRNRIEKTYNNYpkvktv------------k 101
gi 444320013  56 -nisntrnntipnridrvkfedfQNDSRS--KSIKRSSNKNSKNYVTDKHRNLLTHNHDKIptlkrkqlktrklhnyflk 132
gi 410074591  44 -------------snkirnahklRPKEHG--NRIGKISGASRNVALSKRYTNksqr------------------------ 84
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74606041   70 -gsqpSTWSKIKSLFDSNRRDITELKQAYLDY------------RLPNTEPSNTQADIDRLVVNERFKKKLLERK----- 131
gi 74693959   80 -----TWWDRLCGVFSAEQRDLHGMRDAFANYrl--------ppTEELEGRRRRGTASQRIARSETFKKRVLEKM----- 141
gi 1709231    77 --rltKIFQTIRDVFSNDNENMSKMQNVCGDMtril-----kkrSQGRPSYMDTDTAKSRILRSDAFKRKISELK----- 144
gi 74609947   92 esrarMVLNAVKSIFSNEDQTL--MNMASTDInkllr---------nqgyDKNQENLKDSILRSNAFKKKVTELE----- 155
gi 254581000  91 -gtlsKLMKSIKNVFSTEDQDLTLMQQACGNTnamlp---paarRGAHQGAEGRKKLRDRIVRSEAFKRKLLEIK----- 161
gi 363750203  92 ndespTWWERLTSVFSSEQRDLYDMKNAFTNYrl--------pfTNEHESRRRRATNSQRIARSETLKKRMMEKI----- 158
gi 367017224  89 sgglkSIWRSLKTVFSSEDQDLDLMQRACSNVtsm------ipsKNKISGPEERRQLKERIARSEAFKRKVLQVK----- 157
gi 156846681 130 -grlrTLVNSIKSVFSNDTQELNMMQRASENLnvl------vpvSPALSEREERMLIQDRIIRSEVFRKKLMEKR----- 197
gi 367005047 115 -gtltKILSAIKTIFSPEAENMGRMKRVSESLdqllpesnrisdSARCSQMEERRRMRERIGRSEAFKRKLLEKR----- 188
gi 366995830 102 dsllrSLLSRLGTLFSNNEYSMERMQKTCNNIsai-------vqPNPLKSGEEQEILVRRITASKAFQKKLKDIQ----- 169
gi 444320013 133 ksslySIWEFILQIFSNDAHDLKSIRNTSKPLi-----------ESPDISTSNDKLIRDRIGRSQAFRNKIQEFKkkdrt 201
gi 410074591  85 --sfsTFFKFIKSMFSNDEQNLRRLKNECSNIyvn-------spNLESKTNEEYRKIKNRIESSDAFKRKLNELK----- 150
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74606041  132 YERNMLNELRRGRQPYRRNREhrp--------------------------svNSPINHADEVILLRKKLDELEQRLSDAV 185
gi 74693959  142 YDDRMLEQLRAGSRGRRPERP-------------------------------ALPGSDADQVVLLQNRLHKLERQLFETQ 190
gi 1709231   145 YNKQRISELRSGSSDGSSGKD-------------------------------RNQSLYLDREILLQRQIKKRDEKIKALE 193
gi 74609947  156 YNKRMLRDLRRSGVSGNYNII-------------------------------RDDDLEEDRYLLLQKKYQKIKKRLYEVE 204
gi 254581000 162 YDDRMLEQVRRGRSVSGSRRRige-------------------------gyqGIEPLQDDKVGLLQRKLQELDSKVQDMD 216
gi 363750203 159 YDDKMLQQLRETGNPNKRAERll---------------------------glNLSNSESDQVVLLQNRLRKLEQQLFDTQ 211
gi 367017224 158 YDDKMLQELRRGRSRQRSEDPvg-------------------------------sNLTDDQVTLLQKKITHLETRLKNAL 206
gi 156846681 198 HDDVLLEQLKRGRSKTVDTPGyv---------------------------ssSNLNITNDQVTLLQKKIDDMEEKITSLT 250
gi 367005047 189 NDEALLDQLKRGRPSYRQNDDidrenetidaefssdakndisrrdynrkvksRNLNIVDDQVFLLQKKVDSLESKLNIVE 268
gi 366995830 170 YDKQMLTQLKSRVPDKNISYRsq----------------------------lSSNNITEDKIRLLSIKNRELETELNKTK 221
gi 444320013 202 SSKQQPKRLRKRLPINIDSARllrnppiskkth--------nttipynednlTLNNKYFDEVNQLKRKIKKLASELENKD 273
gi 410074591 151 YDRTQIEKIRKTTRLNKHARs------------------------------pRKNGVLDDRLKLLNKEVQDLKRRLHDKS 200
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74606041  186 EELVITKKKLEFVQQKNNLLEELFDDGKMETEYVKSRRNITNLQNSE--RKPElKQLPRSPSPvlHVDPMFTSSPIRATN 263
gi 74693959  191 KELELAKKKLMFAHEKTKLFESLLDDANVDDDYVKSRRRITNLRATTd-NQPAlRSLSPSPQRpyPVNPLFTSSPIRQVN 269
gi 1709231   194 SKLQSLQEALNYSNEKYRILEDLLDSSNIHPSYTKSRRTMSNLARENdeIKPLkIDLSPSPIR--RTNSLFTSSPMKT-- 269
gi 74609947  205 QELKSVQDSLRYSQEMNALLQETLDKANIDDAYLKSRRQIKNLQKEN--VLPE-RELSPSPRR--PIDPLFTSSPVRKSR 279
gi 254581000 217 KELQITQKKLKFAQEKNTLLESLLDDANIDSEYVKSRRDIKNLQKEN--LKPE-AELPPSPRR--SVNPLFTSSPMRKPP 291
gi 363750203 212 KELEIANKKLTFAQEKTKLFESLLDEANVDNEYVKSRRRISNLRTTA--EPQL-RSLSPSPKRpyPLNPLFTSSPMRAHN 288
gi 367017224 207 EDLQITQKRLKFAKEKNTLLESLLDDANIDREYVKSRRDIKNIQRDN--LKPD-TELPPSPRR--TVNPLFTSSPMRNIA 281
gi 156846681 251 KELQISKKKLKFAKEKNLLLQSLLDDANIDSEYVKSRRDIKNLQKEN--LIPE-TDLPPSPKR--TVNPLFTSSPMRKPT 325
gi 367005047 269 KELYLSKKKLKFAKEKNSLLESLLDDANIDSEYVKSRRDIKNLQKEN--LIPE-ADLPPSPRR--TVNPLFTSSPMRKVS 343
gi 366995830 222 DLLQLTKKDLKFAKDKNDLLQSLLRDEKTDEKFLQYKAHVLNSSTGN-------------PGR---NDGYLASSPSSQEN 285
gi 444320013 274 SELEKIRIQLKFANEKNQLREDLLDDAKLDNGYLISRRQIKNLEKQN--VKPK-EELIYSPVR--IPNPKYTSSPMNKPG 348
gi 410074591 201 VELE--------------LVDARLDTALKDNKWLRSRIADMELTEEKgsNISQ-HKMPHISTS--FKDSLQYSSPTKFKR 263
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74606041  264 n-------ILGEGS-----Pqh-------vQQHDNFYEKYPRIPKTERLDNyrssla--nheddYQDRHAENSLSPVRVD 322
gi 74693959  270 --------DSPRKQ-----I----------NKPDDFYAKYPTIPKTELLNKqps--------enAAAGRAKESLSPVRID 318
gi 1709231   270 ------------------------------------YNRDGNIPEMQPLQEnispacptppyrsRETEKEDETLSPISVD 313
gi 74609947  280 n-------GEENGS-----KpktdykhspiKETSNFYDKYPKLPETEQLAQ----------------DKGNHSLSPIRID 331
gi 254581000 292 svqdqeqeQVQGQG-----Q----------DPTQNFYSKYPKIPETELLVQgr----------dR------TSMSPIRID 340
gi 363750203 289 a-------DSPGKH-----P----------NDIHDFYAKYPSLPKTEVLNNkgs--------apDQISNSSESLSPVRID 338
gi 367017224 282 t-------REEPAS-----S------------TTDFYNKYPKIPETETLAN----------------NQRSDSLSPIRID 321
gi 156846681 326 i-------EANEDDdmntgD----------IGPDEFYSKYPKIPETETLTQ----------------HGKEKSLSPIRID 372
gi 367005047 344 g-------STKKNE-----Eev------gkPTTSEFYNKYPKIPETEKLKQ----------------DIRERSLSPINID 389
gi 366995830 286 r-------DNDFG-------------------TPNYYNRYPKIPSTEVLKKn-----------hGRHDHHNNSLSPIRID 328
gi 444320013 349 t-------YDSNPFny-igE----------PKTPYLYDKYRKLPETEQLNKlqiqe---tipsnDNDSGEDISLSPVAVD 407
gi 410074591 264 y-------DSNILE-----S----------DEIKDILKQYGDdk-------------------dYNSDDDTGSLSPIRID 302

                 ....*.
gi 74606041  323 YSKYSS 328
gi 74693959  319 YSKYSS 324
gi 1709231   314 FSSYLS 319
gi 74609947  332 YSRYSS 337
gi 254581000 341 YSKYST 346
gi 363750203 339 YNKYSS 344
gi 367017224 322 YSKYSi 327
gi 156846681 373 YSKYSS 378
gi 367005047 390 YSKYSS 395
gi 366995830 329 FTKYSS 334
gi 444320013 408 ISKYSS 413
gi 410074591 303 YSKYSg 308
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