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    Fubp3 far upstream element (FUSE) binding protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 320267, updated on 31-Jan-2019

    Summary

    Official Symbol
    Fubp3provided by MGI
    Official Full Name
    far upstream element (FUSE) binding protein 3provided by MGI
    Primary source
    MGI:MGI:2443699
    See related
    Ensembl:ENSMUSG00000026843
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FBP3; Marta2; AV006371; A330051M14Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 12.5), limb E14.5 (RPKM 12.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Fubp3 in Genome Data Viewer
    Location:
    2; 2 B
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (31572651..31617526)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (31428245..31473039)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene argininosuccinate synthetase 1 Neighboring gene predicted gene, 32952 Neighboring gene predicted gene 13426 Neighboring gene microRNA 6998 Neighboring gene PR domain containing 12 Neighboring gene exosome component 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC118501

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    far upstream element-binding protein 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033389.4NP_001028561.2  far upstream element-binding protein 3 isoform a

      See identical proteins and their annotated locations for NP_001028561.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK039504, AK167671, BY311525, BY643667, CD538485
      Consensus CDS
      CCDS15899.1
      UniProtKB/TrEMBL
      Q3TIX6, Q8BYI4
      Related
      ENSMUSP00000053474.6, ENSMUST00000055244.12
      Conserved Domains (2) summary
      smart00322
      Location:161232
      KH; K homology RNA-binding domain
      cd00105
      Location:79141
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    2. NM_001290548.1NP_001277477.1  far upstream element-binding protein 3 isoform b

      See identical proteins and their annotated locations for NP_001277477.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a segment of the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK039504, AK167671, BG087512, BY311525, BY643667, CD538485
      Consensus CDS
      CCDS71025.1
      UniProtKB/TrEMBL
      A2AJ72, Q3TIX6, Q8BYI4
      Related
      ENSMUSP00000109110.1, ENSMUST00000113482.7
      Conserved Domains (2) summary
      smart00322
      Location:161232
      KH; K homology RNA-binding domain
      cd00105
      Location:79141
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    3. NM_001363079.1NP_001350008.1  far upstream element-binding protein 3 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (c) lacks an alternate internal aa and has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AL732564
      Conserved Domains (1) summary
      pfam00013
      Location:78140
      KH_1; KH domain
    4. NM_001363080.1NP_001350009.1  far upstream element-binding protein 3 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (d) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AL732564
      Conserved Domains (1) summary
      pfam00013
      Location:79141
      KH_1; KH domain
    5. NM_001363081.1NP_001350010.1  far upstream element-binding protein 3 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (e) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AL732564
      Conserved Domains (1) summary
      pfam00013
      Location:773
      KH_1; KH domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      31572651..31617526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498126.1XP_006498189.1  far upstream element-binding protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006498189.1

      UniProtKB/TrEMBL
      Q3TIX6
      Conserved Domains (2) summary
      smart00322
      Location:161232
      KH; K homology RNA-binding domain
      cd00105
      Location:79141
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    2. XM_006498129.1XP_006498192.1  far upstream element-binding protein 3 isoform X4

      Conserved Domains (2) summary
      smart00322
      Location:161232
      KH; K homology RNA-binding domain
      cd00105
      Location:79141
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    3. XM_017319016.1XP_017174505.1  far upstream element-binding protein 3 isoform X5

      Conserved Domains (1) summary
      pfam00013
      Location:79141
      KH_1; KH domain
    4. XM_006498127.1XP_006498190.1  far upstream element-binding protein 3 isoform X2

      Conserved Domains (2) summary
      smart00322
      Location:160231
      KH; K homology RNA-binding domain
      cd00105
      Location:78140
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    5. XM_017319015.1XP_017174504.1  far upstream element-binding protein 3 isoform X3

      Conserved Domains (1) summary
      pfam00013
      Location:78140
      KH_1; KH domain
    6. XM_006498130.3XP_006498193.1  far upstream element-binding protein 3 isoform X6

      Conserved Domains (2) summary
      smart00322
      Location:475
      KH; K homology RNA-binding domain
      cd00105
      Location:98160
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    7. XM_017319018.1XP_017174507.1  far upstream element-binding protein 3 isoform X7

      Conserved Domains (1) summary
      pfam00013
      Location:773
      KH_1; KH domain

    RNA

    1. XR_001783037.1 RNA Sequence

    2. XR_001783038.1 RNA Sequence

    3. XR_001783039.1 RNA Sequence

    4. XR_001783040.1 RNA Sequence

    5. XR_001783041.1 RNA Sequence

    6. XR_001783042.1 RNA Sequence

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