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FUBP3 far upstream element binding protein 3 [ Homo sapiens (human) ]

Gene ID: 8939, updated on 23-Nov-2021

Summary

Official Symbol
FUBP3provided by HGNC
Official Full Name
far upstream element binding protein 3provided by HGNC
Primary source
HGNC:HGNC:4005
See related
Ensembl:ENSG00000107164 MIM:603536
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBP3
Expression
Ubiquitous expression in thyroid (RPKM 15.5), brain (RPKM 11.3) and 25 other tissues See more
Orthologs
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Genomic context

See FUBP3 in Genome Data Viewer
Location:
9q34.11-q34.12
Exon count:
23
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (130579577..130638352)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (133454964..133513739)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376294 Neighboring gene Sharpr-MPRA regulatory region 5386 Neighboring gene uncharacterized LOC100272217 Neighboring gene microRNA 6856 Neighboring gene ribosomal protein L19 pseudogene 15 Neighboring gene VISTA enhancer hs876 Neighboring gene PR/SET domain 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
GeneReviews: Not available
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
GeneReviews: Not available
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
GeneReviews: Not available
Identification of ten loci associated with height highlights new biological pathways in human growth.
GeneReviews: Not available
Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25229

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
far upstream element-binding protein 3
Names
FUSE-binding protein 3
far upstream element (FUSE) binding protein 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003934.2NP_003925.1  far upstream element-binding protein 3

    See identical proteins and their annotated locations for NP_003925.1

    Status: VALIDATED

    Source sequence(s)
    AL537190, BC001325, BI461266, U69127
    Consensus CDS
    CCDS43893.1
    UniProtKB/Swiss-Prot
    Q96I24
    UniProtKB/TrEMBL
    A0A024R8A7
    Related
    ENSP00000318177.9, ENST00000319725.10
    Conserved Domains (1) summary
    cl00098
    Location:159241
    KH-I; K homology (KH) RNA-binding domain, type I

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    130579577..130638352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519174.2XP_011517476.1  far upstream element-binding protein 3 isoform X4

    See identical proteins and their annotated locations for XP_011517476.1

    Conserved Domains (2) summary
    smart00322
    Location:74145
    KH; K homology RNA-binding domain
    cd00105
    Location:154
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
  2. XM_017015271.1XP_016870760.1  far upstream element-binding protein 3 isoform X6

    Conserved Domains (1) summary
    cd00105
    Location:161226
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
  3. XM_006717313.2XP_006717376.1  far upstream element-binding protein 3 isoform X4

    See identical proteins and their annotated locations for XP_006717376.1

    Conserved Domains (2) summary
    smart00322
    Location:74145
    KH; K homology RNA-binding domain
    cd00105
    Location:154
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
  4. XM_017015269.1XP_016870758.1  far upstream element-binding protein 3 isoform X5

  5. XM_017015270.1XP_016870759.1  far upstream element-binding protein 3 isoform X6

    Conserved Domains (1) summary
    cd00105
    Location:161226
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
  6. XM_017015273.1XP_016870762.1  far upstream element-binding protein 3 isoform X7

  7. XM_017015272.1XP_016870761.1  far upstream element-binding protein 3 isoform X6

    Conserved Domains (1) summary
    cd00105
    Location:161226
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
  8. XM_005272232.2XP_005272289.1  far upstream element-binding protein 3 isoform X1

    See identical proteins and their annotated locations for XP_005272289.1

    Conserved Domains (1) summary
    cl00098
    Location:159241
    KH-I; K homology (KH) RNA-binding domain, type I
  9. XM_011519172.3XP_011517474.1  far upstream element-binding protein 3 isoform X2

    Conserved Domains (2) summary
    smart00322
    Location:161232
    KH; K homology RNA-binding domain
    cd00105
    Location:79141
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
  10. XM_011519173.2XP_011517475.1  far upstream element-binding protein 3 isoform X3

    Conserved Domains (2) summary
    smart00322
    Location:88159
    KH; K homology RNA-binding domain
    cd00105
    Location:668
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

RNA

  1. XR_001746411.2 RNA Sequence

  2. XR_001746412.2 RNA Sequence

  3. XR_001746413.1 RNA Sequence

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