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    Mapk12 mitogen-activated protein kinase 12 [ Mus musculus (house mouse) ]

    Gene ID: 29857, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Mapk12provided by MGI
    Official Full Name
    mitogen-activated protein kinase 12provided by MGI
    Primary source
    MGI:MGI:1353438
    See related
    Ensembl:ENSMUSG00000022610 AllianceGenome:MGI:1353438
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Erk6; Sapk3; Prkm12; P38gamma
    Summary
    Predicted to enable ATP binding activity; MAP kinase activity; and magnesium ion binding activity. Predicted to be involved in several processes, including intracellular signal transduction; myoblast differentiation; and peptidyl-serine phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in cap mesenchyme; lung mesenchyme; metanephros; and olfactory epithelium. Orthologous to human MAPK12 (mitogen-activated protein kinase 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 12.5), bladder adult (RPKM 9.4) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 E3; 15 44.65 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89014787..89025270, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89130584..89141577, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene selenoprotein O Neighboring gene tubulin, gamma complex component 6 Neighboring gene STARR-positive B cell enhancer ABC_E5508 Neighboring gene histone deacetylase 10 Neighboring gene STARR-positive B cell enhancer ABC_E8605 Neighboring gene mitogen-activated protein kinase 11 Neighboring gene plexin B2 Neighboring gene microRNA 7118

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. p38γ MAPK is required for inflammation-associated colon tumorigenesis. Yin N, et al. Oncogene, 2016 Feb 25. PMID 25961922
    2. Selective inhibition of ATPase activity during contraction alters the activation of p38 MAP kinase isoforms in skeletal muscle. Brault JJ, et al. J Cell Biochem, 2013 Jun. PMID 23296747, Free PMC Article
    3. p38γ regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage. Wu CC, et al. Protein Cell, 2010 Jun. PMID 21170151, Free PMC Article
    4. p38-{gamma}-dependent gene silencing restricts entry into the myogenic differentiation program. Gillespie MA, et al. J Cell Biol, 2009 Dec 28. PMID 20026657, Free PMC Article
    5. Effect of Thyroxine on the Structural and Dynamic Features of Cardiac Mitochondria and Mitophagy in Rats. Venediktova N, et al. Cells, 2023 Jan 21. PMID 36766738, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. p38gamma and p38delta modulate innate immune response by regulating MEF2D activation.
      Title: p38γ and p38δ modulate innate immune response by regulating MEF2D activation.
    2. Effect of Thyroxine on the Structural and Dynamic Features of Cardiac Mitochondria and Mitophagy in Rats.
      Title: Effect of Thyroxine on the Structural and Dynamic Features of Cardiac Mitochondria and Mitophagy in Rats.
    3. The pro-tumorigenic activity of p38gamma overexpression in nasopharyngeal carcinoma.
      Title: The pro-tumorigenic activity of p38γ overexpression in nasopharyngeal carcinoma.
    4. p38gamma and p38delta regulate postnatal cardiac metabolism through glycogen synthase 1.
      Title: p38γ and p38δ regulate postnatal cardiac metabolism through glycogen synthase 1.
    5. In mouse hepatocytes, p38gamma induces proliferation after partial hepatectomy by promoting the phosphorylation of retinoblastoma tumour suppressor protein at known CDK target residues. Lack of p38gamma or treatment with the p38gamma inhibitor pirfenidone protects against the chemically induced formation of liver tumours.
      Title: p38γ is essential for cell cycle progression and liver tumorigenesis.
    6. Mitogen-activated protein kinases p38gamma/p38delta deficiency protects against Candida albicans infection by increasing reactive oxygen species and iNOS enzyme production and thus the antifungal capacity of neutrophils and macrophages.
      Title: Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity.
    7. p38gamma mitogen-activated protein kinase mediates inflammatory signaling to promote colon tumorigenesis
      Title: p38γ MAPK is required for inflammation-associated colon tumorigenesis.
    8. p38gamma and p38delta reprogram liver metabolism by modulating neutrophil infiltration and provide a potential target for NAFLD therapy
      Title: p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration.
    9. p38gamma and p38delta control heart growth by modulating mTOR pathway through DEPTOR phosphorylation and subsequent degradation.
      Title: p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation.
    10. Findings provide genetic evidence that p38gamma and p38delta have essential roles in skin tumour development.
      Title: Combined deletion of p38γ and p38δ reduces skin inflammation and protects from carcinogenesis.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase 12
    Names
    ERK-6
    MAP kinase 12
    MAP kinase p38 gamma
    MAPK 12
    extracellular signal-regulated kinase 6
    mitogen-activated protein kinase p38 gamma
    stress-activated protein kinase 3
    NP_001389948.1
    NP_001389949.1
    NP_001389950.1
    NP_001389951.1
    NP_038899.1
    XP_006521121.1
    XP_006521122.1
    XP_006521124.1
    XP_036015349.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403019.1 → NP_001389948.1  mitogen-activated protein kinase 12 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113069

    2. NM_001403020.1 → NP_001389949.1  mitogen-activated protein kinase 12 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC113069

    3. NM_001403021.1 → NP_001389950.1  mitogen-activated protein kinase 12 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC113069

    4. NM_001403022.1 → NP_001389951.1  mitogen-activated protein kinase 12 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC113069

    5. NM_013871.4 → NP_038899.1  mitogen-activated protein kinase 12 isoform 1

      See identical proteins and their annotated locations for NP_038899.1

      Status: VALIDATED

      Source sequence(s)
      AC113069
      Consensus CDS
      CCDS27740.1
      UniProtKB/Swiss-Prot
      O08911, Q9D0M4
      Related
      ENSMUSP00000086207.7, ENSMUST00000088827.8
      Conserved Domains (1) summary
      cd07880
      Location:11 → 353
      STKc_p38gamma; Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase (also called MAPK12)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      89014787..89025270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159456.1 → XP_036015349.1  mitogen-activated protein kinase 12 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:11 → 366
      PKc_like; Protein Kinases, catalytic domain

    2. XM_006521059.5 → XP_006521122.1  mitogen-activated protein kinase 12 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:11 → 360
      PKc_like; Protein Kinases, catalytic domain

    3. XM_006521058.5 → XP_006521121.1  mitogen-activated protein kinase 12 isoform X1

      Conserved Domains (1) summary
      cd07880
      Location:11 → 376
      STKc_p38gamma; Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase (also called MAPK12)

    4. XM_006521061.5 → XP_006521124.1  mitogen-activated protein kinase 12 isoform X6

      Conserved Domains (1) summary
      cl21453
      Location:1 → 195
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08911.1 GenPept UniProtKB/Swiss-Prot:O08911

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