U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    COA3 cytochrome c oxidase assembly factor 3 [ Homo sapiens (human) ]

    Gene ID: 28958, updated on 17-Jun-2024

    Summary

    Official Symbol
    COA3provided by HGNC
    Official Full Name
    cytochrome c oxidase assembly factor 3provided by HGNC
    Primary source
    HGNC:HGNC:24990
    See related
    Ensembl:ENSG00000183978 MIM:614775; AllianceGenome:HGNC:24990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    COX25; hCOA3; CCDC56; HSPC009; MC4DN14; MITRAC12
    Summary
    This gene encodes a member of the cytochrome c oxidase assembly factor family. Studies of a related gene in fly suggest that the encoded protein is localized to mitochondria and is essential for cytochrome c oxidase function. [provided by RefSeq, Nov 2012]
    Expression
    Ubiquitous expression in kidney (RPKM 59.3), duodenum (RPKM 48.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See COA3 in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (42797625..42798704, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (43654765..43655844, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40949643..40950722, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12222 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:40925642-40926189 Neighboring gene Sharpr-MPRA regulatory region 12532 Neighboring gene vacuolar protein sorting 25 homolog Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40932701-40933658 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:40934948-40936147 Neighboring gene WNK lysine deficient protein kinase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12224 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12225 Neighboring gene cyclin N-terminal domain containing 1 Neighboring gene beclin 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:40969798-40970997 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8548 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40975527-40976093 Neighboring gene microRNA 6781

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ50764

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    cytochrome c oxidase assembly factor 3 homolog, mitochondrial
    Names
    coiled-coil domain-containing protein 56
    cytochrome C oxidase assembly factor 3 homolog, mitochondrial
    cytochrome c oxidase assembly protein 3 homolog, mitochondrial
    mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046771.1 RefSeqGene

      Range
      5022..6101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001040431.3NP_001035521.1  cytochrome c oxidase assembly factor 3 homolog, mitochondrial

      See identical proteins and their annotated locations for NP_001035521.1

      Status: REVIEWED

      Source sequence(s)
      AC016889, AL524532, BC002698
      Consensus CDS
      CCDS32660.1
      UniProtKB/Swiss-Prot
      A8K498, Q9Y2R0
      Related
      ENSP00000354762.5, ENST00000328434.8
      Conserved Domains (1) summary
      pfam09813
      Location:991
      Coiled-coil_56; Coiled-coil domain-containing protein 56

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      42797625..42798704 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      43654765..43655844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_014019.1: Suppressed sequence

      Description
      NM_014019.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.