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    ZNF740 zinc finger protein 740 [ Homo sapiens (human) ]

    Gene ID: 283337, updated on 5-Mar-2024

    Summary

    Official Symbol
    ZNF740provided by HGNC
    Official Full Name
    zinc finger protein 740provided by HGNC
    Primary source
    HGNC:HGNC:27465
    See related
    Ensembl:ENSG00000139651 AllianceGenome:HGNC:27465
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Zfp740
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 8.1), ovary (RPKM 7.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF740 in Genome Data Viewer
    Location:
    12q13.13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (53180722..53195142)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (53146318..53160740)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53574506..53588926)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53552337-53552837 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53553211-53553838 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:53559172-53559335 Neighboring gene cysteine sulfinic acid decarboxylase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53565297-53565796 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr12:53568663-53569598 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:53573975-53574533 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4496 Neighboring gene Sharpr-MPRA regulatory region 11900 Neighboring gene Sharpr-MPRA regulatory region 11320 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6403 Neighboring gene integrin subunit beta 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6404 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53609063-53609836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53610051-53610664 Neighboring gene Sharpr-MPRA regulatory region 13987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4497 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4498 Neighboring gene retinoic acid receptor gamma Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4499 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4500 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4501 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53635595-53636507 Neighboring gene uncharacterized LOC122455340

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC61706

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 740
    Names
    oriLyt TD-element-binding protein 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004304.4NP_001004304.1  zinc finger protein 740

      See identical proteins and their annotated locations for NP_001004304.1

      Status: VALIDATED

      Source sequence(s)
      AC073573, AK091946, BC053557
      Consensus CDS
      CCDS44896.1
      UniProtKB/Swiss-Prot
      A8K9M9, Q8NDX6
      Related
      ENSP00000409463.2, ENST00000416904.5
      Conserved Domains (2) summary
      sd00017
      Location:103123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:115140
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      53180722..53195142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      53146318..53160740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)