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    CXCR3 C-X-C motif chemokine receptor 3 [ Homo sapiens (human) ]

    Gene ID: 2833, updated on 6-Jun-2024

    Summary

    Official Symbol
    CXCR3provided by HGNC
    Official Full Name
    C-X-C motif chemokine receptor 3provided by HGNC
    Primary source
    HGNC:HGNC:4540
    See related
    Ensembl:ENSG00000186810 MIM:300574; AllianceGenome:HGNC:4540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R
    Summary
    This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
    Expression
    Biased expression in lymph node (RPKM 6.3), spleen (RPKM 3.4) and 13 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CXCR3 in Genome Data Viewer
    Location:
    Xq13.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (71615919..71618511, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (70049169..70051938, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (70835769..70838361, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:70752005-70753204 Neighboring gene O-linked N-acetylglucosamine (GlcNAc) transferase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:70798494-70799135 Neighboring gene germ cell nuclear acidic peptidase Neighboring gene Sharpr-MPRA regulatory region 14051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29749 Neighboring gene Sharpr-MPRA regulatory region 2992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29750 Neighboring gene chromosome X open reading frame 49 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29751 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29752 Neighboring gene chromosome X open reading frame 49-like Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:70888661-70889860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20899

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The interaction of CXCR4 with HIV-1 gp120 mediates gp120-induced upregulation of the CXCR3 and EMAP2 expression in human lung microvascular endothelial cells PubMed
    env HIV-1 gp120-induced upregulation of CXCR3 and EMAP2 expression and apoptosis requires activation of p38 MAPK in human lung microvascular endothelial cells PubMed
    Nef nef HIV-1 Nef induces variable levels of CXCR3 downregulation in different cell types PubMed
    nef Significant increases in neuronal cell death resulting from HIV-1 Nef-induced upregulation of IP-10 is reduced by an antibody directed against human CXCR3, suggesting an interaction of CXCR3 with Nef PubMed
    Tat tat HIV-1 Tat can inhibit CXCR3-mediated functions by interfering with the chemotactic activity of IP-10/CXCL10, an effect mediated by Tat amino acids 25-31 PubMed
    Vif vif HIV-1 Vif upregulates the expression of chemokine (C-X-C motif) receptor 3 (CXCR3) in Vif-expression T cells PubMed
    Vpu vpu HIV-1 Vpu downregulates the cell surface expression of chemokine (C-X-C motif) receptor 3 (CXCR3, CD183) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables C-X-C chemokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables chemokine binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables chemokine receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of leukocyte migration IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    C-X-C chemokine receptor type 3
    Names
    G protein-coupled receptor 9
    IP-10 receptor
    Mig receptor
    chemokine (C-X-C motif) receptor 3
    chemokine receptor 3
    interferon-inducible protein 10 receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029076.1 RefSeqGene

      Range
      5007..7599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001142797.2NP_001136269.1  C-X-C chemokine receptor type 3 isoform 2

      See identical proteins and their annotated locations for NP_001136269.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in an isoform (2, also known as CXCR3-B) with a longer and distinct N-terminus compared to isoform 1. This isoform acts as functional receptor for chemokine CXCL4/PF4 (PMID:12782716).
      Source sequence(s)
      AF469635, X95876
      Consensus CDS
      CCDS48135.1
      UniProtKB/TrEMBL
      A0A0S2Z3W5
      Related
      ENSP00000362795.4, ENST00000373691.4
      Conserved Domains (1) summary
      cd15180
      Location:101376
      7tmA_CXCR3; CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001504.2NP_001495.1  C-X-C chemokine receptor type 3 isoform 1

      See identical proteins and their annotated locations for NP_001495.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1 (also known as CXCR3-A). This isoform functions as a receptor for chemokines CXCL9/Mig, CXCL10/IP-10, and CXCL11/I-TAC (PMID:12782716).
      Source sequence(s)
      X95876
      Consensus CDS
      CCDS14416.1
      UniProtKB/Swiss-Prot
      B2R982, O15185, P49682, Q7Z710, Q9P2T4, Q9P2T5
      UniProtKB/TrEMBL
      A0A0S2Z3W5
      Related
      ENSP00000362797.3, ENST00000373693.4
      Conserved Domains (1) summary
      cd15180
      Location:54329
      7tmA_CXCR3; CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      71615919..71618511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029436.2XP_016884925.1  C-X-C chemokine receptor type 3 isoform X5

      UniProtKB/TrEMBL
      A0A0S2Z3W9
    2. XM_047442010.1XP_047297966.1  C-X-C chemokine receptor type 3 isoform X3

      UniProtKB/TrEMBL
      A0A0S2Z3W9
    3. XM_005262257.4XP_005262314.1  C-X-C chemokine receptor type 3 isoform X4

      UniProtKB/TrEMBL
      A0A0S2Z3W9
      Conserved Domains (1) summary
      pfam00001
      Location:84218
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    4. XM_005262256.4XP_005262313.1  C-X-C chemokine receptor type 3 isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z3W5
      Conserved Domains (1) summary
      pfam00001
      Location:84328
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    5. XM_017029435.2XP_016884924.1  C-X-C chemokine receptor type 3 isoform X1

      UniProtKB/TrEMBL
      A0A0S2Z3W5
      Conserved Domains (1) summary
      cd15180
      Location:101376
      7tmA_CXCR3; CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      70049169..70051938 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326874.1XP_054182849.1  C-X-C chemokine receptor type 3 isoform X4

      UniProtKB/TrEMBL
      A0A0S2Z3W9
    2. XM_054326872.1XP_054182847.1  C-X-C chemokine receptor type 3 isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z3W5
    3. XM_054326875.1XP_054182850.1  C-X-C chemokine receptor type 3 isoform X5

      UniProtKB/TrEMBL
      A0A0S2Z3W9
    4. XM_054326873.1XP_054182848.1  C-X-C chemokine receptor type 3 isoform X3

      UniProtKB/TrEMBL
      A0A0S2Z3W9
    5. XM_054326871.1XP_054182846.1  C-X-C chemokine receptor type 3 isoform X1

      UniProtKB/TrEMBL
      A0A0S2Z3W5