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    STK32C serine/threonine kinase 32C [ Homo sapiens (human) ]

    Gene ID: 282974, updated on 2-Nov-2024

    Summary

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    Official Symbol
    STK32Cprovided by HGNC
    Official Full Name
    serine/threonine kinase 32Cprovided by HGNC
    Primary source
    HGNC:HGNC:21332
    See related
    Ensembl:ENSG00000165752 AllianceGenome:HGNC:21332
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PKE; YANK3
    Summary
    The protein encoded by this gene is a member of the serine/threonine protein kinase family. It is thought that this family member is functional in brain due to its high expression levels there. DNA methylation differences have been found in this gene in monozygotic twins that are discordant for adolescent depression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
    Expression
    Broad expression in brain (RPKM 5.0), testis (RPKM 3.2) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See STK32C in Genome Data Viewer
    Location:
    10q26.3
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (132207482..132332235, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (133150298..133274880, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (134020986..134145384, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Janus kinase and microtubule interacting protein 3 Neighboring gene JAKMIP3 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134001171-134001672 Neighboring gene dihydropyrimidinase like 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134056390-134057274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134067757-134068258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134068259-134068758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134078043-134078543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134096746-134097345 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:134111356-134111519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2953 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134122180-134122724 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134122725-134123267 Neighboring gene Sharpr-MPRA regulatory region 5064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4223 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:134144980-134145514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4224 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:134152941-134153095 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134166187-134167149 Neighboring gene leucine rich repeat containing 27 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134203032-134203711 Neighboring gene uncharacterized LOC124902526 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134208622-134209145 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134209146-134209668 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2958 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2959 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134211239-134211761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134211762-134212284 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134214271-134215047 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134218733-134219360 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134221245-134221872 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134221873-134222500 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134222501-134223127 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134227291-134227958 Neighboring gene PWWP domain containing 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Serine/threonine kinase 32C is overexpressed in bladder cancer and contributes to tumor progression. Sun E, et al. Cancer Biol Ther, 2019. PMID 30359551, Free PMC Article
    2. Genome-wide methylomic analysis of monozygotic twins discordant for adolescent depression. Dempster EL, et al. Biol Psychiatry, 2014 Dec 15. PMID 24929637, Free PMC Article
    3. Replication of recently described type 2 diabetes gene variants in a South Indian population. Chidambaram M, et al. Metabolism, 2010 Dec. PMID 20580033
    4. The protein kinase complement of the human genome. Manning G, et al. Science, 2002 Dec 6. PMID 12471243
    5. Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants. Wistow G, et al. Mol Vis, 2002 Jun 15. PMID 12107413

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Silencing of STK32C inhibited the activity of the HMGB1 pathway and regulated the expression of key genes in this pathway.
      Title: Serine/threonine kinase 32C is overexpressed in bladder cancer and contributes to tumor progression.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Replication of recently described type 2 diabetes gene variants in a South Indian population.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC23665

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 32C
    Names
    PKE protein kinase
    testicular tissue protein Li 187
    yet another novel kinase 3
    NP_001305807.1
    NP_001305808.1
    NP_001305809.1
    NP_001305810.1
    NP_001305811.1
    NP_001305812.1
    NP_775846.2
    XP_011537990.1
    XP_011537992.1
    XP_011537995.1
    XP_011537996.1
    XP_011537997.1
    XP_016871589.1
    XP_016871590.1
    XP_024303715.2
    XP_024303717.2
    XP_047281068.1
    XP_047281069.1
    XP_047281070.1
    XP_047281071.1
    XP_054221615.1
    XP_054221616.1
    XP_054221617.1
    XP_054221618.1
    XP_054221619.1
    XP_054221620.1
    XP_054221621.1
    XP_054221622.1
    XP_054221623.1
    XP_054221624.1
    XP_054221625.1
    XP_054221626.1
    XP_054221627.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001318878.2 → NP_001305807.1  serine/threonine-protein kinase 32C isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK302102, AL590105, CD369442, HY020713, HY070240
      UniProtKB/TrEMBL
      B7Z7J1, I6L972
      Conserved Domains (2) summary
      smart00220
      Location:106 → 361
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05578
      Location:105 → 366
      STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

    2. NM_001318879.2 → NP_001305808.1  serine/threonine-protein kinase 32C isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK302102, BC045760, CD369442, HY018020
      Consensus CDS
      CCDS81525.1
      UniProtKB/TrEMBL
      I6L972
      Related
      ENSP00000357611.1, ENST00000368622.5
      Conserved Domains (1) summary
      cd05578
      Location:1 → 236
      STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

    3. NM_001318880.2 → NP_001305809.1  serine/threonine-protein kinase 32C isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) shares the 5' terminal exon but lacks the remaining exons found in variant 1, and instead contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is significantly shorter than isoform a.
      Source sequence(s)
      AA782619, AL590105, CD674243, HY020713, HY070240
      Consensus CDS
      CCDS81527.1
      UniProtKB/TrEMBL
      H0Y431
      Related
      ENSP00000389112.2, ENST00000456004.1

    4. NM_001318881.2 → NP_001305810.1  serine/threonine-protein kinase 32C isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) shares the 5' terminal exon but lacks the remaining exons found in variant 1, and instead contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is significantly shorter than isoform a.
      Source sequence(s)
      AL590105, AW770528, BE009030, BF508609, DA574949, HY020713
      Consensus CDS
      CCDS81526.1
      UniProtKB/TrEMBL
      H0Y349
      Related
      ENSP00000357608.4, ENST00000368619.3

    5. NM_001318882.2 → NP_001305811.1  serine/threonine-protein kinase 32C isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) shares the 5' terminal exon but lacks the remaining exons found in variant 1, and instead contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (f) has a distinct C-terminus and is significantly shorter than isoform a.
      Source sequence(s)
      AI911241, AL590105, BF508609, HY020713, HY106710, HY301367

    6. NM_001318883.2 → NP_001305812.1  serine/threonine-protein kinase 32C isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses an alternate splice site in the 5' terminal exon and lacks the remaining exons found in variant 1, but instead contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (g) has a distinct C-terminus and is significantly shorter than isoform a.
      Source sequence(s)
      AL590105, BF449072, BF508609, HY020713

    7. NM_173575.4 → NP_775846.2  serine/threonine-protein kinase 32C isoform b

      See identical proteins and their annotated locations for NP_775846.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AK302102, AY098866, CD369442
      Consensus CDS
      CCDS7666.1
      UniProtKB/Swiss-Prot
      Q5T0Q5, Q86UE1, Q86UX6
      UniProtKB/TrEMBL
      A0A140VJW0, I6L972
      Related
      ENSP00000298630.3, ENST00000298630.8
      Conserved Domains (2) summary
      smart00220
      Location:93 → 348
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05578
      Location:92 → 353
      STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

    RNA

    1. NR_134911.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) contains an alternate 5' terminal exon and includes an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, which results in an ORF that is in-frame with the coding region of variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK057849, AK302102, BM749615, CD369442
      Related
      ENST00000462160.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      132207482..132332235 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539693.3 → XP_011537995.1  serine/threonine-protein kinase 32C isoform X5

      See identical proteins and their annotated locations for XP_011537995.1

      UniProtKB/TrEMBL
      I6L972
      Conserved Domains (1) summary
      cd05578
      Location:1 → 236
      STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

    2. XM_011539688.2 → XP_011537990.1  serine/threonine-protein kinase 32C isoform X1

      Conserved Domains (2) summary
      smart00220
      Location:106 → 366
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05578
      Location:105 → 371
      STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

    3. XM_011539690.3 → XP_011537992.1  serine/threonine-protein kinase 32C isoform X2

      UniProtKB/TrEMBL
      I6L972
      Conserved Domains (2) summary
      smart00220
      Location:93 → 353
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05578
      Location:92 → 358
      STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

    4. XM_011539695.2 → XP_011537997.1  serine/threonine-protein kinase 32C isoform X5

      See identical proteins and their annotated locations for XP_011537997.1

      UniProtKB/TrEMBL
      I6L972
      Conserved Domains (1) summary
      cd05578
      Location:1 → 236
      STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

    5. XM_047425115.1 → XP_047281071.1  serine/threonine-protein kinase 32C isoform X5

    6. XM_047425114.1 → XP_047281070.1  serine/threonine-protein kinase 32C isoform X6

    7. XM_024447949.2 → XP_024303717.2  serine/threonine-protein kinase 32C isoform X7

    8. XM_011539694.2 → XP_011537996.1  serine/threonine-protein kinase 32C isoform X5

      See identical proteins and their annotated locations for XP_011537996.1

      UniProtKB/TrEMBL
      I6L972
      Conserved Domains (1) summary
      cd05578
      Location:1 → 236
      STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

    9. XM_047425113.1 → XP_047281069.1  serine/threonine-protein kinase 32C isoform X4

    10. XM_047425112.1 → XP_047281068.1  serine/threonine-protein kinase 32C isoform X3

    11. XM_024447947.2 → XP_024303715.2  serine/threonine-protein kinase 32C isoform X8

      Related
      ENSP00000357609.3, ENST00000368620.2

    12. XM_017016101.2 → XP_016871590.1  serine/threonine-protein kinase 32C isoform X10

    13. XM_017016100.2 → XP_016871589.1  serine/threonine-protein kinase 32C isoform X9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      133150298..133274880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365649.1 → XP_054221624.1  serine/threonine-protein kinase 32C isoform X5

    2. XM_054365640.1 → XP_054221615.1  serine/threonine-protein kinase 32C isoform X1

    3. XM_054365641.1 → XP_054221616.1  serine/threonine-protein kinase 32C isoform X2

    4. XM_054365644.1 → XP_054221619.1  serine/threonine-protein kinase 32C isoform X5

    5. XM_054365646.1 → XP_054221621.1  serine/threonine-protein kinase 32C isoform X5

    6. XM_054365645.1 → XP_054221620.1  serine/threonine-protein kinase 32C isoform X6

    7. XM_054365648.1 → XP_054221623.1  serine/threonine-protein kinase 32C isoform X7

    8. XM_054365647.1 → XP_054221622.1  serine/threonine-protein kinase 32C isoform X5

    9. XM_054365643.1 → XP_054221618.1  serine/threonine-protein kinase 32C isoform X4

    10. XM_054365642.1 → XP_054221617.1  serine/threonine-protein kinase 32C isoform X3

    11. XM_054365650.1 → XP_054221625.1  serine/threonine-protein kinase 32C isoform X8

    12. XM_054365652.1 → XP_054221627.1  serine/threonine-protein kinase 32C isoform X10

    13. XM_054365651.1 → XP_054221626.1  serine/threonine-protein kinase 32C isoform X9

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86UX6.1 GenPept UniProtKB/Swiss-Prot:Q86UX6

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