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    Csnk1e casein kinase 1, epsilon [ Mus musculus (house mouse) ]

    Gene ID: 27373, updated on 31-Jan-2019

    Summary

    Official Symbol
    Csnk1eprovided by MGI
    Official Full Name
    casein kinase 1, epsilonprovided by MGI
    Primary source
    MGI:MGI:1351660
    See related
    Ensembl:ENSMUSG00000022433
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    tau; CKIe; AI426939; AI551861; AW457082; CK1epsilon; KC1epsilon
    Summary
    The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
    Expression
    Broad expression in whole brain E14.5 (RPKM 28.8), CNS E14 (RPKM 28.1) and 25 other tissues See more

    Genomic context

    See Csnk1e in Genome Data Viewer
    Location:
    15; 15 E1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (79417852..79455579, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (79248282..79272487, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) Neighboring gene transmembrane protein 184b Neighboring gene microRNA 1943 Neighboring gene predicted gene, 41359 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cellular protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    circadian behavior ISO
    Inferred from Sequence Orthology
    more info
     
    circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    circadian rhythm TAS
    Traceable Author Statement
    more info
    PubMed 
    endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of non-canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cellular protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cellular protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    casein kinase I isoform epsilon; casein kinase I
    Names
    CKI-epsilon
    KC1 epsilon
    NP_001276827.1
    NP_001276828.1
    NP_038795.3
    XP_006521106.1
    XP_011243951.1
    XP_011243952.1
    XP_011243953.1
    XP_011243954.1
    XP_011243955.1
    XP_011243956.1
    XP_017172146.1
    XP_017172147.1
    XP_017172148.1
    XP_017172149.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289898.1NP_001276827.1  casein kinase I isoform epsilon isoform a

      See identical proteins and their annotated locations for NP_001276827.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4 and 5 encode the same isoform (a).
      Source sequence(s)
      AL591913
      Consensus CDS
      CCDS27640.1
      UniProtKB/Swiss-Prot
      Q9JMK2
      Related
      ENSMUSP00000113341.1, ENSMUST00000117786.7
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    2. NM_001289899.1NP_001276828.1  casein kinase I isoform epsilon isoform b

      See identical proteins and their annotated locations for NP_001276828.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AK158709
      Consensus CDS
      CCDS70646.1
      UniProtKB/TrEMBL
      Q3TYE1
      Related
      ENSMUSP00000113096.1, ENSMUST00000122044.7
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    3. NM_001359862.1NP_001346791.1  casein kinase I isoform epsilon isoform a

      Status: VALIDATED

      Description
      Transcript Variant: Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4 and 5 encode the same isoform (a).
      Source sequence(s)
      AL591913
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    4. NM_001359863.1NP_001346792.1  casein kinase I isoform epsilon isoform a

      Status: VALIDATED

      Description
      Transcript Variant: Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4 and 5 encode the same isoform (a).
      Source sequence(s)
      AL591913
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    5. NM_013767.6NP_038795.3  casein kinase I isoform epsilon isoform a

      See identical proteins and their annotated locations for NP_038795.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, 4 and 5 encode the same isoform (a).
      Source sequence(s)
      AL591913
      Consensus CDS
      CCDS27640.1
      UniProtKB/Swiss-Prot
      Q9JMK2
      Related
      ENSMUSP00000113975.1, ENSMUST00000120859.7
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      79417852..79455579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245651.1XP_011243953.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_011243953.1

      Conserved Domains (2) summary
      COG0515
      Location:8285
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    2. XM_011245652.2XP_011243954.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_011243954.1

      Conserved Domains (2) summary
      COG0515
      Location:8285
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    3. XM_017316658.1XP_017172147.1  casein kinase I isoform X2

      UniProtKB/Swiss-Prot
      Q9JMK2
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    4. XM_011245649.1XP_011243951.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_011243951.1

      Conserved Domains (2) summary
      COG0515
      Location:8285
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    5. XM_011245653.2XP_011243955.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_011243955.1

      Conserved Domains (2) summary
      COG0515
      Location:8285
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    6. XM_017316659.1XP_017172148.1  casein kinase I isoform X2

      UniProtKB/Swiss-Prot
      Q9JMK2
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    7. XM_011245654.2XP_011243956.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_011243956.1

      Conserved Domains (2) summary
      COG0515
      Location:8285
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    8. XM_011245650.2XP_011243952.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_011243952.1

      Conserved Domains (2) summary
      COG0515
      Location:8285
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    9. XM_006521043.3XP_006521106.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_006521106.1

      Conserved Domains (2) summary
      COG0515
      Location:8285
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    10. XM_017316657.1XP_017172146.1  casein kinase I isoform X2

      UniProtKB/Swiss-Prot
      Q9JMK2
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    11. XM_017316660.1XP_017172149.1  casein kinase I isoform X3

      UniProtKB/TrEMBL
      Q3TYE1
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
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