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    Csnk1e casein kinase 1, epsilon [ Mus musculus (house mouse) ]

    Gene ID: 27373, updated on 1-Mar-2024

    Summary

    Official Symbol
    Csnk1eprovided by MGI
    Official Full Name
    casein kinase 1, epsilonprovided by MGI
    Primary source
    MGI:MGI:1351660
    See related
    Ensembl:ENSMUSG00000022433 AllianceGenome:MGI:1351660
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    tau; CKIe; CK1epsilon; KC1epsilon
    Summary
    The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
    Expression
    Broad expression in whole brain E14.5 (RPKM 28.8), CNS E14 (RPKM 28.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Csnk1e in Genome Data Viewer
    Location:
    15 37.71 cM; 15 E1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79302054..79339779, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79417852..79455579, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) Neighboring gene transmembrane protein 184b Neighboring gene microRNA 1943 Neighboring gene STARR-seq mESC enhancer starr_39180 Neighboring gene STARR-seq mESC enhancer starr_39181 Neighboring gene predicted gene 16059 Neighboring gene STARR-seq mESC enhancer starr_39185 Neighboring gene STARR-seq mESC enhancer starr_39186 Neighboring gene predicted gene, 41359 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (4)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in circadian behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within circadian rhythm TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of non-canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    casein kinase I isoform epsilon; casein kinase I
    Names
    CKI-epsilon
    KC1 epsilon
    NP_001276827.1
    NP_001276828.1
    NP_001346791.1
    NP_001346792.1
    NP_001398803.1
    NP_001398804.1
    NP_001398805.1
    NP_001398806.1
    NP_001398807.1
    NP_001398808.1
    NP_001398809.1
    NP_001398810.1
    NP_038795.3
    XP_006521106.1
    XP_011243952.1
    XP_011243953.1
    XP_011243954.1
    XP_011243955.1
    XP_011243956.1
    XP_017172146.1
    XP_017172149.1
    XP_030104453.1
    XP_030104457.1
    XP_036015339.1
    XP_036015340.1
    XP_036015341.1
    XP_036015342.1
    XP_036015343.1
    XP_036015344.1
    XP_036015345.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289898.3NP_001276827.1  casein kinase I isoform epsilon isoform a

      See identical proteins and their annotated locations for NP_001276827.1

      Status: VALIDATED

      Source sequence(s)
      AC165278
      Consensus CDS
      CCDS27640.1
      UniProtKB/Swiss-Prot
      Q8R389, Q9JMK2
      UniProtKB/TrEMBL
      Q9QUI3
      Related
      ENSMUSP00000113341.2, ENSMUST00000117786.9
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    2. NM_001289899.2NP_001276828.1  casein kinase I isoform epsilon isoform b

      See identical proteins and their annotated locations for NP_001276828.1

      Status: VALIDATED

      Source sequence(s)
      AC165278
      Consensus CDS
      CCDS70646.1
      UniProtKB/TrEMBL
      Q3TYE1
      Related
      ENSMUSP00000113096.2, ENSMUST00000122044.8
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    3. NM_001359862.2NP_001346791.1  casein kinase I isoform epsilon isoform a

      Status: VALIDATED

      Source sequence(s)
      AC165278
      Consensus CDS
      CCDS27640.1
      UniProtKB/Swiss-Prot
      Q8R389, Q9JMK2
      UniProtKB/TrEMBL
      Q9QUI3
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    4. NM_001359863.2NP_001346792.1  casein kinase I isoform epsilon isoform a

      Status: VALIDATED

      Source sequence(s)
      AC165278
      Consensus CDS
      CCDS27640.1
      UniProtKB/Swiss-Prot
      Q8R389, Q9JMK2
      UniProtKB/TrEMBL
      Q9QUI3
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    5. NM_001411874.1NP_001398803.1  casein kinase I isoform epsilon isoform b

      Status: VALIDATED

      Source sequence(s)
      AC165278
      UniProtKB/TrEMBL
      Q3TYE1
    6. NM_001411875.1NP_001398804.1  casein kinase I isoform epsilon isoform b

      Status: VALIDATED

      Source sequence(s)
      AC165278
      UniProtKB/TrEMBL
      Q3TYE1
    7. NM_001411876.1NP_001398805.1  casein kinase I isoform epsilon isoform a

      Status: VALIDATED

      Source sequence(s)
      AC165278
      UniProtKB/Swiss-Prot
      Q8R389, Q9JMK2
      UniProtKB/TrEMBL
      Q9QUI3
    8. NM_001411877.1NP_001398806.1  casein kinase I isoform epsilon isoform a

      Status: VALIDATED

      Source sequence(s)
      AC165278
      UniProtKB/Swiss-Prot
      Q8R389, Q9JMK2
      UniProtKB/TrEMBL
      Q9QUI3
    9. NM_001411878.1NP_001398807.1  casein kinase I isoform epsilon isoform a

      Status: VALIDATED

      Source sequence(s)
      AC165278
      UniProtKB/Swiss-Prot
      Q8R389, Q9JMK2
      UniProtKB/TrEMBL
      Q9QUI3
    10. NM_001411879.1NP_001398808.1  casein kinase I isoform epsilon isoform a

      Status: VALIDATED

      Source sequence(s)
      AC165278
      UniProtKB/Swiss-Prot
      Q8R389, Q9JMK2
      UniProtKB/TrEMBL
      Q9QUI3
    11. NM_001411880.1NP_001398809.1  casein kinase I isoform epsilon isoform a

      Status: VALIDATED

      Source sequence(s)
      AC165278
      UniProtKB/Swiss-Prot
      Q8R389, Q9JMK2
      UniProtKB/TrEMBL
      Q9QUI3
    12. NM_001411881.1NP_001398810.1  casein kinase I isoform epsilon isoform c

      Status: VALIDATED

      Source sequence(s)
      AC165278
    13. NM_013767.8NP_038795.3  casein kinase I isoform epsilon isoform a

      See identical proteins and their annotated locations for NP_038795.3

      Status: VALIDATED

      Source sequence(s)
      AC165278
      Consensus CDS
      CCDS27640.1
      UniProtKB/Swiss-Prot
      Q8R389, Q9JMK2
      UniProtKB/TrEMBL
      Q9QUI3
      Related
      ENSMUSP00000113975.2, ENSMUST00000120859.9
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      79302054..79339779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245651.2XP_011243953.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_011243953.1

      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    2. XM_036159448.1XP_036015341.1  casein kinase I isoform X1

      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    3. XM_011245652.3XP_011243954.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_011243954.1

      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    4. XM_011245653.4XP_011243955.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_011243955.1

      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    5. XM_017316657.2XP_017172146.1  casein kinase I isoform X2

      UniProtKB/Swiss-Prot
      Q8R389, Q9JMK2
      UniProtKB/TrEMBL
      Q9QUI3
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    6. XM_006521043.4XP_006521106.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_006521106.1

      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    7. XM_036159446.1XP_036015339.1  casein kinase I isoform X1

      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    8. XM_036159451.1XP_036015344.1  casein kinase I isoform X2

      UniProtKB/Swiss-Prot
      Q8R389, Q9JMK2
      UniProtKB/TrEMBL
      Q9QUI3
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    9. XM_011245650.4XP_011243952.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_011243952.1

      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    10. XM_030248593.1XP_030104453.1  casein kinase I isoform X1

      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    11. XM_036159447.1XP_036015340.1  casein kinase I isoform X1

      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    12. XM_011245654.4XP_011243956.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_011243956.1

      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    13. XM_036159450.1XP_036015343.1  casein kinase I isoform X2

      UniProtKB/Swiss-Prot
      Q8R389, Q9JMK2
      UniProtKB/TrEMBL
      Q9QUI3
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    14. XM_036159452.1XP_036015345.1  casein kinase I isoform X2

      UniProtKB/Swiss-Prot
      Q8R389, Q9JMK2
      UniProtKB/TrEMBL
      Q9QUI3
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    15. XM_036159449.1XP_036015342.1  casein kinase I isoform X2

      UniProtKB/Swiss-Prot
      Q8R389, Q9JMK2
      UniProtKB/TrEMBL
      Q9QUI3
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    16. XM_030248597.2XP_030104457.1  casein kinase I isoform X2

      UniProtKB/Swiss-Prot
      Q8R389, Q9JMK2
      UniProtKB/TrEMBL
      Q9QUI3
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
    17. XM_017316660.2XP_017172149.1  casein kinase I isoform X3

      UniProtKB/TrEMBL
      Q3TYE1
      Conserved Domains (1) summary
      cd14125
      Location:8282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon