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    DKK4 dickkopf WNT signaling pathway inhibitor 4 [ Homo sapiens (human) ]

    Gene ID: 27121, updated on 5-Mar-2024

    Summary

    Official Symbol
    DKK4provided by HGNC
    Official Full Name
    dickkopf WNT signaling pathway inhibitor 4provided by HGNC
    Primary source
    HGNC:HGNC:2894
    See related
    Ensembl:ENSG00000104371 MIM:605417; AllianceGenome:HGNC:2894
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DKK-4
    Summary
    This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DKK4 in Genome Data Viewer
    Location:
    8p11.21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (42374063..42391322, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (42644359..42661636, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (42231581..42234747, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379395 Neighboring gene inhibitor of nuclear factor kappa B kinase subunit beta Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:42163399-42164071 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:42164072-42164743 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:42179455-42179956 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:42179957-42180456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:42188156-42188656 Neighboring gene ribosomal protein L5 pseudogene 23 Neighboring gene DNA polymerase beta Neighboring gene H3K27ac hESC enhancers GRCh37_chr8:42248902-42249402 and GRCh37_chr8:42249403-42249903 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:42258699-42258918 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27311 Neighboring gene voltage dependent anion channel 3 Neighboring gene solute carrier family 20 member 2 Neighboring gene Sharpr-MPRA regulatory region 15103 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:42331955-42332466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:42332467-42332978 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:42333451-42333976 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:42333977-42334500 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:42350219-42351086 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:42359656-42360855 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19157 Neighboring gene small integral membrane protein 19

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC129562, MGC129563

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables co-receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor antagonist activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    dickkopf-related protein 4
    Names
    dickkopf-4
    hDkk-4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014420.3NP_055235.1  dickkopf-related protein 4 precursor

      See identical proteins and their annotated locations for NP_055235.1

      Status: REVIEWED

      Source sequence(s)
      AC107885, AF177397, BX105775
      Consensus CDS
      CCDS6130.1
      UniProtKB/Swiss-Prot
      Q3KNX0, Q9UBT3, Q9Y4C3
      Related
      ENSP00000220812.2, ENST00000220812.3
      Conserved Domains (2) summary
      pfam06607
      Location:145202
      Prokineticin; Prokineticin
      pfam04706
      Location:4191
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      42374063..42391322 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013316.2XP_016868805.1  dickkopf-related protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q3KNX0, Q9UBT3, Q9Y4C3
      Conserved Domains (2) summary
      pfam06607
      Location:145202
      Prokineticin; Prokineticin
      pfam04706
      Location:4191
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region
    2. XM_011544488.3XP_011542790.1  dickkopf-related protein 4 isoform X1

      See identical proteins and their annotated locations for XP_011542790.1

      UniProtKB/Swiss-Prot
      Q3KNX0, Q9UBT3, Q9Y4C3
      Conserved Domains (2) summary
      pfam06607
      Location:145202
      Prokineticin; Prokineticin
      pfam04706
      Location:4191
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      42644359..42661636 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360295.1XP_054216270.1  dickkopf-related protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q3KNX0, Q9UBT3, Q9Y4C3
    2. XM_054360296.1XP_054216271.1  dickkopf-related protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q3KNX0, Q9UBT3, Q9Y4C3