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Dkk4 dickkopf WNT signaling pathway inhibitor 4 [ Mus musculus (house mouse) ]

Gene ID: 234130, updated on 2-Nov-2024

Summary

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Official Symbol
Dkk4provided by MGI
Official Full Name
dickkopf WNT signaling pathway inhibitor 4provided by MGI
Primary source
MGI:MGI:2385299
See related
Ensembl:ENSMUSG00000031535 AllianceGenome:MGI:2385299
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dkk-4
Summary
Predicted to enable co-receptor binding activity and receptor antagonist activity. Acts upstream of or within Wnt signaling pathway and negative regulation of hair follicle placode formation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human DKK4 (dickkopf WNT signaling pathway inhibitor 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Dkk4 in Genome Data Viewer
Location:
8 A2; 8 11.42 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (23113701..23117563)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22623685..22628018)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30086 Neighboring gene predicted gene, 30135 Neighboring gene RIKEN cDNA A930013F10 gene Neighboring gene polymerase (DNA directed), beta Neighboring gene STARR-positive B cell enhancer ABC_E6626 Neighboring gene inhibitor of kappaB kinase beta Neighboring gene predicted gene 15346

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Wnt signaling modulator DKK4 inhibits colorectal cancer metastasis through an AKT/Wnt/β-catenin negative feedback pathway. Liang J, et al. J Biol Chem, 2022 Nov. PMID 36181792, Free PMC Article
  2. The effects of Dickkopf-4 on the proliferation, differentiation, and apoptosis of osteoblasts. Hiramitsu S, et al. Endocrinology, 2013 Dec. PMID 24105477
  3. Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair. Cui CY, et al. PLoS One, 2010 Apr 1. PMID 20386733, Free PMC Article
  4. Genome-wide copy number variation study in anorectal malformations. Wong EH, et al. Hum Mol Genet, 2013 Feb 1. PMID 23108157
  5. Hierarchical patterning modes orchestrate hair follicle morphogenesis. Glover JD, et al. PLoS Biol, 2017 Jul. PMID 28700594, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Wnt signaling modulator DKK4 inhibits colorectal cancer metastasis through an AKT/Wnt/beta-catenin negative feedback pathway.
    Title: Wnt signaling modulator DKK4 inhibits colorectal cancer metastasis through an AKT/Wnt/β-catenin negative feedback pathway.
  2. the dynamic state of Dkk4 itself and its interaction with Lrp6 modulates Wnt function during Meibomian gland development, with a novel limitation of Dkk4 action by proteolytic cleavage.
    Title: Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development.
  3. sweat gland development shows a relay of regulatory steps initiated by Wnt/beta-catenin - itself modulated by Dkk4 - with subsequent participation of Eda and Shh pathways.
    Title: Involvement of Wnt, Eda and Shh at defined stages of sweat gland development.
  4. These results showed that Dkk4 functions as an inhibitor of osteoblastogenesis through Wnt/beta-catenin signaling, providing new insights into the relationship between Wnt/beta-catenin signaling and Dkk4 in bone formation.
    Title: The effects of Dickkopf-4 on the proliferation, differentiation, and apoptosis of osteoblasts.
  5. It would appear that deregulation of the WNT pathway by overexpression of DKK4 may further impair WNT signaling and lead to Anorectal malformations.
    Title: Genome-wide copy number variation study in anorectal malformations.
  6. Dkk4 affects an auxiliary pathway for Eda-independent development of secondary hair
    Title: Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair.
  7. Microarray profiling of genes differentially regulated by short exposure to recombinant Eda-A1 in embryonic eda(-/-) skin explants, was performed to identify direct targets of ectodysplasin pathway.
    Title: Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes.
  8. Dkk4 acts in a negative feedback loop to attenuate canonical Wnt signaling and may facilitate a switch to the non-canonical Wnt planar cell polarity pathway that is involved in cell movements during morphogenesis.
    Title: The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC25705

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables co-receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables receptor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of hair follicle placode formation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dickkopf-related protein 4
Names
dickkopf homolog 4
dickkopf-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145592.2 → NP_663567.1  dickkopf-related protein 4 precursor

    See identical proteins and their annotated locations for NP_663567.1

    Status: PROVISIONAL

    Source sequence(s)
    AC121835
    Consensus CDS
    CCDS22180.1
    UniProtKB/Swiss-Prot
    Q8VEJ3
    Related
    ENSMUSP00000033936.7, ENSMUST00000033936.8
    Conserved Domains (2) summary
    pfam06607
    Location:145 → 202
    Prokineticin
    pfam04706
    Location:41 → 91
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    23113701..23117563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509098.4 → XP_006509161.1  dickkopf-related protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006509161.1

    UniProtKB/Swiss-Prot
    Q8VEJ3
    Conserved Domains (2) summary
    pfam06607
    Location:145 → 202
    Prokineticin
    pfam04706
    Location:41 → 91
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VEJ3.1 GenPept UniProtKB/Swiss-Prot:Q8VEJ3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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