U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dkk4 dickkopf WNT signaling pathway inhibitor 4 [ Mus musculus (house mouse) ]

Gene ID: 234130, updated on 27-Feb-2024

Summary

Official Symbol
Dkk4provided by MGI
Official Full Name
dickkopf WNT signaling pathway inhibitor 4provided by MGI
Primary source
MGI:MGI:2385299
See related
Ensembl:ENSMUSG00000031535 AllianceGenome:MGI:2385299
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dkk-4
Summary
Predicted to enable co-receptor binding activity and receptor antagonist activity. Acts upstream of or within Wnt signaling pathway and negative regulation of hair follicle placode formation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human DKK4 (dickkopf WNT signaling pathway inhibitor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Dkk4 in Genome Data Viewer
Location:
8 A2; 8 11.42 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (23113701..23117563)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22623685..22628018)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30086 Neighboring gene predicted gene, 30135 Neighboring gene RIKEN cDNA A930013F10 gene Neighboring gene polymerase (DNA directed), beta Neighboring gene STARR-positive B cell enhancer ABC_E6626 Neighboring gene inhibitor of kappaB kinase beta Neighboring gene predicted gene 15346

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC25705

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables co-receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables receptor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
dickkopf-related protein 4
Names
dickkopf homolog 4
dickkopf-4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145592.2NP_663567.1  dickkopf-related protein 4 precursor

    See identical proteins and their annotated locations for NP_663567.1

    Status: PROVISIONAL

    Source sequence(s)
    AC121835
    Consensus CDS
    CCDS22180.1
    UniProtKB/Swiss-Prot
    Q8VEJ3
    Related
    ENSMUSP00000033936.7, ENSMUST00000033936.8
    Conserved Domains (2) summary
    pfam06607
    Location:145202
    Prokineticin
    pfam04706
    Location:4191
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    23113701..23117563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509098.4XP_006509161.1  dickkopf-related protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006509161.1

    UniProtKB/Swiss-Prot
    Q8VEJ3
    Conserved Domains (2) summary
    pfam06607
    Location:145202
    Prokineticin
    pfam04706
    Location:4191
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region