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DKK4 dickkopf WNT signaling pathway inhibitor 4 [ Homo sapiens (human) ]

Gene ID: 27121, updated on 7-Jun-2020

Summary

Official Symbol
DKK4provided by HGNC
Official Full Name
dickkopf WNT signaling pathway inhibitor 4provided by HGNC
Primary source
HGNC:HGNC:2894
See related
Ensembl:ENSG00000104371 MIM:605417
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DKK-4
Summary
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See DKK4 in Genome Data Viewer
Location:
8p11.21
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (42373194..42391322, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (42231586..42234674, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379395 Neighboring gene inhibitor of nuclear factor kappa B kinase subunit beta Neighboring gene ribosomal protein L5 pseudogene 23 Neighboring gene DNA polymerase beta Neighboring gene voltage dependent anion channel 3 Neighboring gene solute carrier family 20 member 2 Neighboring gene small integral membrane protein 19

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129562, MGC129563

Gene Ontology Provided by GOA

Function Evidence Code Pubs
co-receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
receptor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Wnt signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of canonical Wnt signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of hair follicle placode formation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dickkopf-related protein 4
Names
dickkopf-4
hDkk-4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014420.3NP_055235.1  dickkopf-related protein 4 precursor

    See identical proteins and their annotated locations for NP_055235.1

    Status: REVIEWED

    Source sequence(s)
    AC107885, AF177397, BX105775
    Consensus CDS
    CCDS6130.1
    UniProtKB/Swiss-Prot
    Q9UBT3
    Related
    ENSP00000220812.2, ENST00000220812.3
    Conserved Domains (2) summary
    pfam06607
    Location:145202
    Prokineticin; Prokineticin
    pfam04706
    Location:4191
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    42373194..42391322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013316.1XP_016868805.1  dickkopf-related protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9UBT3
    Conserved Domains (2) summary
    pfam06607
    Location:145202
    Prokineticin; Prokineticin
    pfam04706
    Location:4191
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region
  2. XM_011544488.2XP_011542790.1  dickkopf-related protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011542790.1

    UniProtKB/Swiss-Prot
    Q9UBT3
    Conserved Domains (2) summary
    pfam06607
    Location:145202
    Prokineticin; Prokineticin
    pfam04706
    Location:4191
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region
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