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    TMEM256 transmembrane protein 256 [ Homo sapiens (human) ]

    Gene ID: 254863, updated on 17-Jun-2024

    Summary

    Official Symbol
    TMEM256provided by HGNC
    Official Full Name
    transmembrane protein 256provided by HGNC
    Primary source
    HGNC:HGNC:28618
    See related
    Ensembl:ENSG00000205544 MIM:617779; AllianceGenome:HGNC:28618
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C17orf61
    Summary
    Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in fat (RPKM 45.8), duodenum (RPKM 45.5) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TMEM256 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7402975..7404097, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7307020..7308140, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7306294..7307416, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7258016-7258542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7258543-7259069 Neighboring gene transmembrane protein 95 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:7269638-7269860 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:7283926-7284426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8114 Neighboring gene tyrosine kinase non receptor 1 Neighboring gene TMEM256-PLSCR3 readthrough (NMD candidate) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8115 Neighboring gene phospholipid scramblase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8116 Neighboring gene neuroligin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7323127-7323646 Neighboring gene spermatid maturation 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC40107

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    transmembrane protein 256
    Names
    UPF0451 protein C17orf61

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_054929.1 RefSeqGene

      Range
      5035..6157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_152766.5NP_689979.1  transmembrane protein 256 precursor

      See identical proteins and their annotated locations for NP_689979.1

      Status: VALIDATED

      Source sequence(s)
      BC030270, BM749297
      Consensus CDS
      CCDS11102.1
      UniProtKB/Swiss-Prot
      Q8N2U0
      Related
      ENSP00000301939.3, ENST00000302422.4
      Conserved Domains (1) summary
      pfam04241
      Location:2298
      DUF423; Protein of unknown function (DUF423)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      7402975..7404097 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_016107299.1 Reference GRCh38.p14 PATCHES

      Range
      23432..24554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      7307020..7308140 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)