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PLSCR3 phospholipid scramblase 3 [ Homo sapiens (human) ]

Gene ID: 57048, updated on 21-Dec-2019

Summary

Official Symbol
PLSCR3provided by HGNC
Official Full Name
phospholipid scramblase 3provided by HGNC
Primary source
HGNC:HGNC:16495
See related
Ensembl:ENSG00000187838 MIM:607611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in spleen (RPKM 12.9), fat (RPKM 12.1) and 25 other tissues See more
Orthologs

Genomic context

See PLSCR3 in Genome Data Viewer
Location:
17p13.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (7389727..7394525, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7293046..7298162, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 Neighboring gene potassium channel tetramerization domain containing 11 Neighboring gene transmembrane protein 95 Neighboring gene TMEM256-PLSCR3 readthrough (NMD candidate) Neighboring gene tyrosine kinase non receptor 1 Neighboring gene transmembrane protein 256 Neighboring gene neuroligin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough TMEM256-PLSCR3

Readthrough gene: TMEM256-PLSCR3, Included gene: TMEM256

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
phospholipid scramblase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid scramblase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
cholesterol homeostasis IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
phospholipid scrambling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid scrambling NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
phospholipid scramblase 3
Names
PL scramblase 3
ca(2+)-dependent phospholipid scramblase 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201576.2NP_001188505.1  phospholipid scramblase 3 isoform 1

    See identical proteins and their annotated locations for NP_001188505.1

    Status: VALIDATED

    Source sequence(s)
    AC113189
    Consensus CDS
    CCDS42253.1
    UniProtKB/Swiss-Prot
    Q9NRY6
    Related
    ENSP00000316021.11, ENST00000324822.15
    Conserved Domains (2) summary
    PRK05641
    Location:3171
    PRK05641; putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
    pfam03803
    Location:62284
    Scramblase
  2. NM_001369407.1NP_001356336.1  phospholipid scramblase 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC113189
    Related
    ENSP00000459019.1, ENST00000574401.5
    Conserved Domains (2) summary
    PRK05641
    Location:3171
    PRK05641; putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
    pfam03803
    Location:62284
    Scramblase
  3. NM_001369420.1NP_001356349.1  phospholipid scramblase 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113189
    Conserved Domains (1) summary
    cl02043
    Location:62219
    LOR; LURP-one-related
  4. NM_001369421.1NP_001356350.1  phospholipid scramblase 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113189
    Conserved Domains (1) summary
    cl02043
    Location:1115
    LOR; LURP-one-related
  5. NM_001369422.1NP_001356351.1  phospholipid scramblase 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113189
    Conserved Domains (1) summary
    cl02043
    Location:1115
    LOR; LURP-one-related
  6. NM_020360.4NP_065093.2  phospholipid scramblase 3 isoform 1

    See identical proteins and their annotated locations for NP_065093.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC011735, BC093026
    Consensus CDS
    CCDS42253.1
    UniProtKB/Swiss-Prot
    Q9NRY6
    Related
    ENSP00000483743.2, ENST00000619711.5
    Conserved Domains (2) summary
    PRK05641
    Location:3171
    PRK05641; putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
    pfam03803
    Location:62284
    Scramblase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    7389727..7394525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_016107299.1 Reference GRCh38.p13 PATCHES

    Range
    10184..14982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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