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    PANX1 pannexin 1 [ Homo sapiens (human) ]

    Gene ID: 24145, updated on 13-Apr-2024

    Summary

    Official Symbol
    PANX1provided by HGNC
    Official Full Name
    pannexin 1provided by HGNC
    Primary source
    HGNC:HGNC:8599
    See related
    Ensembl:ENSG00000110218 MIM:608420; AllianceGenome:HGNC:8599
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PX1; MRS1; OOMD7; OZEMA7; UNQ2529
    Summary
    The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 7.4), appendix (RPKM 5.7) and 25 other tissues See more
    Orthologs
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    Genomic context

    See PANX1 in Genome Data Viewer
    Location:
    11q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (94128841..94181968)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (94045617..94098852)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (93862007..93915134)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene hephaestin like 1 Neighboring gene uncharacterized LOC124902735 Neighboring gene PHB1 pseudogene 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:93821850-93822408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:93822409-93822965 Neighboring gene NANOG hESC enhancer GRCh37_chr11:93838940-93839521 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:93852752-93853716 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5401 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:93866399-93866898 Neighboring gene Sharpr-MPRA regulatory region 4215 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:93885086-93886285 Neighboring gene uncharacterized LOC105369435 Neighboring gene actin related protein 2/3 complex subunit 3 pseudogene 3 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:93970861-93972060 Neighboring gene NANOG hESC enhancer GRCh37_chr11:93995336-93995837 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:94011033-94012232

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env ATP is released from HIV-1 target cells through pannexin-1 channels upon interaction between the HIV-1 envelope protein and specific target cell receptors CD4 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC21309

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT enables gap junction hemi-channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables leak channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables monoatomic anion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protease binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables scaffold protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural molecule activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables wide pore channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in ATP transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in monoatomic anion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in monoatomic cation transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in monoatomic cation transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in oogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-1 alpha production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-1 beta production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of macrophage cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ATP IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ischemia IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in bleb IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in gap junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027936.1 RefSeqGene

      Range
      4914..58041
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_015368.4NP_056183.2  pannexin-1

      See identical proteins and their annotated locations for NP_056183.2

      Status: REVIEWED

      Source sequence(s)
      AF398509, AK074897, AP003966, AY359023, BC016931, CA418094
      Consensus CDS
      CCDS8296.1
      UniProtKB/Swiss-Prot
      O75968, Q543A0, Q6UW26, Q96AM9, Q96L77, Q96RD7, Q96RS5
      UniProtKB/TrEMBL
      B6ETL5
      Related
      ENSP00000227638.3, ENST00000227638.8
      Conserved Domains (1) summary
      cl11443
      Location:233339
      Cas6; Class 1 CRISPR-associated endoribonuclease Cas6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      94128841..94181968
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426702.1XP_047282658.1  pannexin-1 isoform X1

    2. XM_011542734.3XP_011541036.1  pannexin-1 isoform X1

      See identical proteins and their annotated locations for XP_011541036.1

      Conserved Domains (1) summary
      cl11443
      Location:91197
      Cas6-I-III; CRISPR/Cas system-associated RAMP superfamily protein Cas6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      94045617..94098852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368281.1XP_054224256.1  pannexin-1 isoform X1

    2. XM_054368280.1XP_054224255.1  pannexin-1 isoform X1