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    Med24 mediator complex subunit 24 [ Mus musculus (house mouse) ]

    Gene ID: 23989, updated on 23-Jun-2021

    Summary

    Official Symbol
    Med24provided by MGI
    Official Full Name
    mediator complex subunit 24provided by MGI
    Primary source
    MGI:MGI:1344385
    See related
    Ensembl:ENSMUSG00000017210
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pp; Gse; Thr; DRIP; Gse2; Trap; 100kD; R7552; 911GSE; Pparb2; R75526; Thrap4; DRIP100; Pparbp2; Trap100; AU040102; AW547152; D11Ertd307; D11Ertd307e
    Summary
    This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene may form a submodule of the mediator complex that magnifies the effects of activators on the general transcription machinery. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thymus adult (RPKM 41.8), testis adult (RPKM 39.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Med24 in Genome Data Viewer
    Location:
    11 D; 11 62.46 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98595423..98620245, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98704597..98729419, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (98565905..98590749, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 Neighboring gene predicted gene, 38985 Neighboring gene colony stimulating factor 3 (granulocyte) Neighboring gene predicted gene, 22059 Neighboring gene predicted gene, 31252 Neighboring gene thyroid hormone receptor alpha Neighboring gene nuclear receptor subfamily 1, group D, member 1 Neighboring gene predicted gene, 31862

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0130

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mediator of RNA polymerase II transcription subunit 24
    Names
    genetic suppressor element 2
    mTRAP100
    peroxisome proliferation activation receptor binding protein 2
    thyroid hormone receptor associated protein 4
    thyroid hormone receptor-associated protein 100 kDa
    thyroid hormone receptor-associated protein complex 100 kDa component

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361993.2NP_001348922.1  mediator of RNA polymerase II transcription subunit 24 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variants 1 and 5, encodes isoform 1.
      Source sequence(s)
      AL590963
      Consensus CDS
      CCDS88247.1
      Conserved Domains (1) summary
      pfam11277
      Location:11004
      Med24_N; Mediator complex subunit 24 N-terminal
    2. NM_001361994.2NP_001348923.1  mediator of RNA polymerase II transcription subunit 24 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2, and 5 all encode the same isoform.
      Source sequence(s)
      AL590963
      Consensus CDS
      CCDS88247.1
      Conserved Domains (1) summary
      pfam11277
      Location:11004
      Med24_N; Mediator complex subunit 24 N-terminal
    3. NM_001361995.2NP_001348924.1  mediator of RNA polymerase II transcription subunit 24 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 3 and 6, encodes isoform 2.
      Source sequence(s)
      AL590963
      Consensus CDS
      CCDS25361.2
      Conserved Domains (1) summary
      pfam11277
      Location:1985
      Med24_N; Mediator complex subunit 24 N-terminal
    4. NM_001378926.1NP_001365855.1  mediator of RNA polymerase II transcription subunit 24 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 1 and 2, encodes isoform 1.
      Source sequence(s)
      AL590963
      Related
      ENSMUSP00000098069.3, ENSMUST00000100500.9
      Conserved Domains (1) summary
      pfam11277
      Location:11004
      Med24_N; Mediator complex subunit 24 N-terminal
    5. NM_001378927.1NP_001365856.1  mediator of RNA polymerase II transcription subunit 24 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 3 and 4, encodes isoform 2.
      Source sequence(s)
      AL590963
      Conserved Domains (1) summary
      pfam11277
      Location:1985
      Med24_N; Mediator complex subunit 24 N-terminal
    6. NM_011869.3NP_035999.2  mediator of RNA polymerase II transcription subunit 24 isoform 2

      See identical proteins and their annotated locations for NP_035999.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variants 4 and 6, encodes isoform 2.
      Source sequence(s)
      AL590963
      Consensus CDS
      CCDS25361.2
      UniProtKB/Swiss-Prot
      Q99K74
      Related
      ENSMUSP00000017354.7, ENSMUST00000017354.13
      Conserved Domains (1) summary
      pfam11277
      Location:1985
      Med24_N; Mediator complex subunit 24 N-terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      98595423..98620245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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