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MED24 mediator complex subunit 24 [ Homo sapiens (human) ]

Gene ID: 9862, updated on 9-Sep-2018

Summary

Official Symbol
MED24provided by HGNC
Official Full Name
mediator complex subunit 24provided by HGNC
Primary source
HGNC:HGNC:22963
See related
Ensembl:ENSG00000008838 MIM:607000; Vega:OTTHUMG00000133329
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MED5; CRSP4; ARC100; THRAP4; CRSP100; DRIP100; TRAP100
Summary
This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 18.9), brain (RPKM 13.4) and 25 other tissues See more
Orthologs

Genomic context

See MED24 in Genome Data Viewer
Location:
17q21.1
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (40019097..40054742, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38175350..38210889, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene proteasome 26S subunit, non-ATPase 3 Neighboring gene colony stimulating factor 3 Neighboring gene small nucleolar RNA, C/D box 124 Neighboring gene microRNA 6884 Neighboring gene thyroid hormone receptor alpha Neighboring gene nuclear receptor subfamily 1 group D member 1 Neighboring gene male specific lethal 1 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network.
NHGRI GWA Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
NHGRI GWA Catalog
Multiple loci are associated with white blood cell phenotypes.
NHGRI GWA Catalog
The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.
NHGRI GWA Catalog

Pathways from BioSystems

  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
    Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
    PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
  • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
  • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
    Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...
  • Transcriptional regulation of white adipocyte differentiation, organism-specific biosystem (from REACTOME)
    Transcriptional regulation of white adipocyte differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8748, KIAA0130

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nuclear receptor transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
thyroid hormone receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coregulator activity IDA
Inferred from Direct Assay
more info
PubMed 
vitamin D receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mediator complex NAS
Non-traceable Author Statement
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 24
Names
CRSP complex subunit 4
activator-recruited cofactor 100 kDa component
cofactor required for Sp1 transcriptional activation subunit 4
cofactor required for Sp1 transcriptional activation, subunit 4, 100kDa
mediator of RNA polymerase II transcription, subunit 24 homolog
thyroid hormone receptor-associated protein 4
thyroid hormone receptor-associated protein complex 100 kDa component
vitamin D3 receptor-interacting protein complex 100 kDa component
vitamin D3 receptor-interacting protein complex component DRIP100

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079518.1NP_001072986.1  mediator of RNA polymerase II transcription subunit 24 isoform 2

    See identical proteins and their annotated locations for NP_001072986.1

    Status: REVIEWED

    Description
    Transcript Variant: Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AK022508, BC011375, D50920, DB144359
    Consensus CDS
    CCDS42315.1
    UniProtKB/Swiss-Prot
    O75448
    Related
    ENSP00000377685.2, OTTHUMP00000164459, ENST00000394127.6, OTTHUMT00000257143
    Conserved Domains (1) summary
    pfam11277
    Location:1974
    Med24_N; Mediator complex subunit 24 N-terminal
  2. NM_001267797.1NP_001254726.1  mediator of RNA polymerase II transcription subunit 24 isoform 2

    See identical proteins and their annotated locations for NP_001254726.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5_ coding region compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC090844, AC102799, AK291040
    Consensus CDS
    CCDS42315.1
    UniProtKB/Swiss-Prot
    O75448
    Related
    ENSP00000348610.3, OTTHUMP00000261720, ENST00000356271.7, OTTHUMT00000446858
    Conserved Domains (1) summary
    pfam11277
    Location:1974
    Med24_N; Mediator complex subunit 24 N-terminal
  3. NM_001330211.1NP_001317140.1  mediator of RNA polymerase II transcription subunit 24 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC090844, AC102799, BU619328
    Consensus CDS
    CCDS82117.1
    UniProtKB/TrEMBL
    F5GY88
    Related
    ENSP00000440100.2, ENST00000501516.7
    Conserved Domains (1) summary
    pfam11277
    Location:11006
    Med24_N; Mediator complex subunit 24 N-terminal
  4. NM_014815.3NP_055630.2  mediator of RNA polymerase II transcription subunit 24 isoform 1

    See identical proteins and their annotated locations for NP_055630.2

    Status: REVIEWED

    Description
    Transcript Variant: Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF277379, BC011375, D50920, DB144359
    Consensus CDS
    CCDS11359.1
    UniProtKB/Swiss-Prot
    O75448
    Related
    ENSP00000377686.2, OTTHUMP00000164462, ENST00000394128.6, OTTHUMT00000257147
    Conserved Domains (1) summary
    pfam11277
    Location:1987
    Med24_N; Mediator complex subunit 24 N-terminal

RNA

  1. NR_052017.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC090844, AC102799, AK303745
    Related
    ENST00000535508.6, OTTHUMT00000446869

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    40019097..40054742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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