Format

Send to:

Choose Destination
    • Showing Current items.

    Arih2 ariadne RBR E3 ubiquitin protein ligase 2 [ Mus musculus (house mouse) ]

    Gene ID: 23807, updated on 31-Jan-2019

    Summary

    Official Symbol
    Arih2provided by MGI
    Official Full Name
    ariadne RBR E3 ubiquitin protein ligase 2provided by MGI
    Primary source
    MGI:MGI:1344361
    See related
    Ensembl:ENSMUSG00000064145
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARI2; UIP48; TRIAD1; AI843547
    Expression
    Ubiquitous expression in testis adult (RPKM 32.8), thymus adult (RPKM 11.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Arih2 in Genome Data Viewer
    Location:
    9; 9 F2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (108602942..108649530, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (108505273..108551711, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene DALR anticodon binding domain containing 3 Neighboring gene WD repeat domain 6 Neighboring gene prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) Neighboring gene solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 Neighboring gene protein kinase, cAMP dependent regulatory, type II alpha

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    developmental cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    hematopoietic stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with Cul5-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase ARIH2
    Names
    ARI-2
    RING-type E3 ubiquitin transferase ARIH2
    ariadne 2
    ariadne homolog 2
    protein ariadne-2 homolog
    ubcM4-interacting protein 48
    NP_035920.1
    XP_006511788.1
    XP_006511791.1
    XP_011241183.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357283.1NP_001344212.1  E3 ubiquitin-protein ligase ARIH2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      CT571271
      Conserved Domains (3) summary
      smart00647
      Location:207269
      IBR; In Between Ring fingers
      pfam01485
      Location:297329
      IBR; IBR domain, a half RING-finger domain
      cd16773
      Location:136189
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    2. NM_001357285.1NP_001344214.1  E3 ubiquitin-protein ligase ARIH2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      AK167104, BC051998, CT571271
      Conserved Domains (3) summary
      smart00647
      Location:207269
      IBR; In Between Ring fingers
      pfam01485
      Location:297329
      IBR; IBR domain, a half RING-finger domain
      cd16773
      Location:136189
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    3. NM_001357286.1NP_001344215.1  E3 ubiquitin-protein ligase ARIH2 isoform b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.z
      Source sequence(s)
      CT571271
      Conserved Domains (3) summary
      smart00647
      Location:136198
      IBR; In Between Ring fingers
      pfam01485
      Location:226258
      IBR; IBR domain, a half RING-finger domain
      cd16773
      Location:65118
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    4. NM_011790.5NP_035920.1  E3 ubiquitin-protein ligase ARIH2 isoform a

      See identical proteins and their annotated locations for NP_035920.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      BC051998, CT571271
      Consensus CDS
      CCDS23534.1
      UniProtKB/Swiss-Prot
      Q9Z1K6
      UniProtKB/TrEMBL
      Q3TK92
      Related
      ENSMUSP00000013338.8, ENSMUST00000013338.13
      Conserved Domains (3) summary
      smart00647
      Location:207269
      IBR; In Between Ring fingers
      pfam01485
      Location:297329
      IBR; IBR domain, a half RING-finger domain
      cd16773
      Location:136189
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

    RNA

    1. NR_151664.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      CT571271

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      108602942..108649530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511725.2XP_006511788.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

      UniProtKB/Swiss-Prot
      Q9Z1K6
      UniProtKB/TrEMBL
      Q3TK92
      Conserved Domains (3) summary
      smart00647
      Location:207269
      IBR; In Between Ring fingers
      pfam01485
      Location:297329
      IBR; IBR domain, a half RING-finger domain
      cd16773
      Location:136189
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    2. XM_006511728.3XP_006511791.1  E3 ubiquitin-protein ligase ARIH2 isoform X2

      Conserved Domains (3) summary
      smart00647
      Location:136198
      IBR; In Between Ring fingers
      pfam01485
      Location:226258
      IBR; IBR domain, a half RING-finger domain
      cd16773
      Location:65118
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    3. XM_011242881.2XP_011241183.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

      Related
      ENSMUSP00000141914.1, ENSMUST00000193190.5
      Conserved Domains (1) summary
      smart00647
      Location:207269
      IBR; In Between Ring fingers

    RNA

    1. XR_871083.2 RNA Sequence

    Support Center