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ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 [ Homo sapiens (human) ]

Gene ID: 10425, updated on 5-Apr-2020

Summary

Official Symbol
ARIH2provided by HGNC
Official Full Name
ariadne RBR E3 ubiquitin protein ligase 2provided by HGNC
Primary source
HGNC:HGNC:690
See related
Ensembl:ENSG00000177479 MIM:605615
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARI2; TRIAD1
Summary
The protein encoded by this gene is an E3 ubiquitin-protein ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in some cancer cells and may inhibit myelopoiesis. Several transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been determined yet. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in thyroid (RPKM 18.6), heart (RPKM 17.4) and 25 other tissues See more
Orthologs

Genomic context

See ARIH2 in Genome Data Viewer
Location:
3p21.31
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (48918821..48986382)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (48956265..49022974)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene PRKAR2A antisense RNA 1 Neighboring gene solute carrier family 25 member 20 Neighboring gene ARIH2 opposite strand lncRNA Neighboring gene prolyl 4-hydroxylase, transmembrane Neighboring gene WD repeat domain 6 Neighboring gene DALR anticodon binding domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10938, FLJ33921

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin conjugating enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with Cul5-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase ARIH2
Names
RING-type E3 ubiquitin transferase ARIH2
all-trans retinoic acid inducible RING finger
ariadne homolog 2
protein ariadne-2 homolog
NP_001304262.1
NP_001304263.1
NP_001336138.1
NP_001336139.1
NP_001336140.1
NP_001336141.1
NP_001336142.1
NP_001336143.1
NP_001336144.1
NP_001336145.1
NP_001336146.1
NP_001336147.1
NP_001336148.1
NP_001336149.1
NP_001336150.1
NP_001336151.1
NP_001336152.1
NP_001336153.1
NP_001336154.1
NP_001336155.1
NP_001336156.1
NP_001336157.1
NP_001336158.1
NP_001336159.1
NP_006312.1
XP_011531569.1
XP_011531570.1
XP_011531573.1
XP_011531575.1
XP_011531578.1
XP_016861022.1
XP_016861023.1
XP_016861024.1
XP_016861025.1
XP_024309076.1
XP_024309077.1
XP_024309078.1
XP_024309079.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317333.2NP_001304262.1  E3 ubiquitin-protein ligase ARIH2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variants 2, 4, 5, and 6, encodes isoform a.
    Source sequence(s)
    AC134028, AC137630, AK223550, AL110187
    Consensus CDS
    CCDS2780.1
    UniProtKB/Swiss-Prot
    O95376
    UniProtKB/TrEMBL
    Q53ET9, Q6IBL8
    Related
    ENSP00000403222.1, ENST00000449376.5
    Conserved Domains (3) summary
    smart00647
    Location:208270
    IBR; In Between Ring fingers
    pfam01485
    Location:298330
    IBR; IBR domain, a half RING-finger domain
    cd16773
    Location:137190
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  2. NM_001317334.2NP_001304263.1  E3 ubiquitin-protein ligase ARIH2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variant 7, encodes isoform b.
    Source sequence(s)
    AC137630, AL110187, BC000422, BG476221, BM928477
    UniProtKB/Swiss-Prot
    O95376
    Conserved Domains (3) summary
    smart00647
    Location:66128
    IBR; In Between Ring fingers
    pfam01485
    Location:156188
    IBR; IBR domain, a half RING-finger domain
    cd16773
    Location:148
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  3. NM_001349209.2NP_001336138.1  E3 ubiquitin-protein ligase ARIH2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 1, 2, 5, and 6, encodes isoform a.
    Source sequence(s)
    AC134028, AC137630
    Consensus CDS
    CCDS2780.1
    Conserved Domains (3) summary
    smart00647
    Location:208270
    IBR; In Between Ring fingers
    pfam01485
    Location:298330
    IBR; IBR domain, a half RING-finger domain
    cd16773
    Location:137190
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  4. NM_001349210.2NP_001336139.1  E3 ubiquitin-protein ligase ARIH2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 1, 2, 4, and 6, encodes isoform a.
    Source sequence(s)
    AC134028, AC137630
    Consensus CDS
    CCDS2780.1
    Conserved Domains (3) summary
    smart00647
    Location:208270
    IBR; In Between Ring fingers
    pfam01485
    Location:298330
    IBR; IBR domain, a half RING-finger domain
    cd16773
    Location:137190
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  5. NM_001349211.2NP_001336140.1  E3 ubiquitin-protein ligase ARIH2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 2, 4, and 5, encodes isoform a.
    Source sequence(s)
    AC134028, AC137630
    Consensus CDS
    CCDS2780.1
    Conserved Domains (3) summary
    smart00647
    Location:208270
    IBR; In Between Ring fingers
    pfam01485
    Location:298330
    IBR; IBR domain, a half RING-finger domain
    cd16773
    Location:137190
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  6. NM_001349212.2NP_001336141.1  E3 ubiquitin-protein ligase ARIH2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 3, encodes isoform b.
    Source sequence(s)
    AC134028, AC137630
    Conserved Domains (3) summary
    smart00647
    Location:66128
    IBR; In Between Ring fingers
    pfam01485
    Location:156188
    IBR; IBR domain, a half RING-finger domain
    cd16773
    Location:148
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  7. NM_001349213.2NP_001336142.1  E3 ubiquitin-protein ligase ARIH2 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variant 9, encodes the longest isoform (c).
    Source sequence(s)
    AC134028, AC137630
    Conserved Domains (2) summary
    smart00647
    Location:208270
    IBR; In Between Ring fingers
    cd16773
    Location:137190
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  8. NM_001349214.2NP_001336143.1  E3 ubiquitin-protein ligase ARIH2 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variant 8, encodes the longest isoform (c).
    Source sequence(s)
    AC134028, AC137630
    Conserved Domains (2) summary
    smart00647
    Location:208270
    IBR; In Between Ring fingers
    cd16773
    Location:137190
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  9. NM_001349215.2NP_001336144.1  E3 ubiquitin-protein ligase ARIH2 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) encodes isoform d.
    Source sequence(s)
    AC134028, AC137630
    Conserved Domains (3) summary
    smart00647
    Location:208270
    IBR; In Between Ring fingers
    pfam01485
    Location:298330
    IBR; IBR domain, a half RING-finger domain
    cd16773
    Location:137190
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  10. NM_001349216.2NP_001336145.1  E3 ubiquitin-protein ligase ARIH2 isoform e precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) encodes isoform e.
    Source sequence(s)
    AC134028, AC137630
    Conserved Domains (2) summary
    smart00647
    Location:136198
    IBR; In Between Ring fingers
    cd16773
    Location:65118
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  11. NM_001349217.2NP_001336146.1  E3 ubiquitin-protein ligase ARIH2 isoform f precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 13, 14, 15, and 16, encodes isoform f.
    Source sequence(s)
    AC134028, AC137630
    Conserved Domains (3) summary
    smart00647
    Location:136198
    IBR; In Between Ring fingers
    pfam01485
    Location:226258
    IBR; IBR domain, a half RING-finger domain
    cd16773
    Location:65118
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  12. NM_001349218.2NP_001336147.1  E3 ubiquitin-protein ligase ARIH2 isoform f precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 12, 14, 15, and 16, encodes isoform f.
    Source sequence(s)
    AC134028, AC137630
    Conserved Domains (3) summary
    smart00647
    Location:136198
    IBR; In Between Ring fingers
    pfam01485
    Location:226258
    IBR; IBR domain, a half RING-finger domain
    cd16773
    Location:65118
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  13. NM_001349219.2NP_001336148.1  E3 ubiquitin-protein ligase ARIH2 isoform f precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 12, 13, 15, and 16, encodes isoform f.
    Source sequence(s)
    AC134028, AC137630
    Conserved Domains (3) summary
    smart00647
    Location:136198
    IBR; In Between Ring fingers
    pfam01485
    Location:226258
    IBR; IBR domain, a half RING-finger domain
    cd16773
    Location:65118
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  14. NM_001349220.2NP_001336149.1  E3 ubiquitin-protein ligase ARIH2 isoform f precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 12, 13, 14, and 16, encodes isoform f.
    Source sequence(s)
    AC134028, AC137630
    Conserved Domains (3) summary
    smart00647
    Location:136198
    IBR; In Between Ring fingers
    pfam01485
    Location:226258
    IBR; IBR domain, a half RING-finger domain
    cd16773
    Location:65118
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  15. NM_001349221.2NP_001336150.1  E3 ubiquitin-protein ligase ARIH2 isoform f precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 12, 13, 14, and 15, encodes isoform f.
    Source sequence(s)
    AC134028, AC137630
    Conserved Domains (3) summary
    smart00647
    Location:136198
    IBR; In Between Ring fingers
    pfam01485
    Location:226258
    IBR; IBR domain, a half RING-finger domain
    cd16773
    Location:65118
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  16. NM_001349222.2NP_001336151.1  E3 ubiquitin-protein ligase ARIH2 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 18, 19, 20, and 21, encodes isoform g.
    Source sequence(s)
    AC134028, AC137630
    Conserved Domains (3) summary
    smart00647
    Location:124186
    IBR; In Between Ring fingers
    pfam01485
    Location:214246
    IBR; IBR domain, a half RING-finger domain
    cd16773
    Location:53106
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  17. NM_001349223.2NP_001336152.1  E3 ubiquitin-protein ligase ARIH2 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 17, 19, 20, and 21, encodes isoform g.
    Source sequence(s)
    AC134028, AC137630
    Conserved Domains (3) summary
    smart00647
    Location:124186
    IBR; In Between Ring fingers
    pfam01485
    Location:214246
    IBR; IBR domain, a half RING-finger domain
    cd16773
    Location:53106
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  18. NM_001349224.2NP_001336153.1  E3 ubiquitin-protein ligase ARIH2 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 17, 18, 20, and 21, encodes isoform g.
    Source sequence(s)
    AC134028, AC137630
    Conserved Domains (3) summary
    smart00647
    Location:124186
    IBR; In Between Ring fingers
    pfam01485
    Location:214246
    IBR; IBR domain, a half RING-finger domain
    cd16773
    Location:53106
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  19. NM_001349225.2NP_001336154.1  E3 ubiquitin-protein ligase ARIH2 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variants 17, 18, 19, and 21, encodes isoform g.
    Source sequence(s)
    AC134028, AC137630
    Conserved Domains (3) summary
    smart00647
    Location:124186
    IBR; In Between Ring fingers
    pfam01485
    Location:214246
    IBR; IBR domain, a half RING-finger domain
    cd16773
    Location:53106
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  20. NM_001349226.2NP_001336155.1  E3 ubiquitin-protein ligase ARIH2 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variants 17, 18, 19, and 20, encodes isoform g.
    Source sequence(s)
    AC134028, AC137630
    Conserved Domains (3) summary
    smart00647
    Location:124186
    IBR; In Between Ring fingers
    pfam01485
    Location:214246
    IBR; IBR domain, a half RING-finger domain
    cd16773
    Location:53106
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  21. NM_001349227.2NP_001336156.1  E3 ubiquitin-protein ligase ARIH2 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22) encodes isoform h.
    Source sequence(s)
    AC134028, AC137630
    Conserved Domains (1) summary
    smart00647
    Location:2587
    IBR; In Between Ring fingers
  22. NM_001349228.2NP_001336157.1  E3 ubiquitin-protein ligase ARIH2 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variants 24 and 25, encodes isoform i.
    Source sequence(s)
    AC134028
  23. NM_001349229.2NP_001336158.1  E3 ubiquitin-protein ligase ARIH2 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variants 23 and 25, encodes isoform i.
    Source sequence(s)
    AC134028
  24. NM_001349230.2NP_001336159.1  E3 ubiquitin-protein ligase ARIH2 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variants 23 and 24, encodes isoform i.
    Source sequence(s)
    AC134028
    Related
    ENSP00000404838.1, ENST00000449729.5
  25. NM_006321.4NP_006312.1  E3 ubiquitin-protein ligase ARIH2 isoform a

    See identical proteins and their annotated locations for NP_006312.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variants 1, 4, 5, and 6, encodes isoform a.
    Source sequence(s)
    AC137630, AL110187, BC000422, BG476221
    Consensus CDS
    CCDS2780.1
    UniProtKB/Swiss-Prot
    O95376
    UniProtKB/TrEMBL
    Q6IBL8
    Related
    ENSP00000348769.4, ENST00000356401.8
    Conserved Domains (3) summary
    smart00647
    Location:208270
    IBR; In Between Ring fingers
    pfam01485
    Location:298330
    IBR; IBR domain, a half RING-finger domain
    cd16773
    Location:137190
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

RNA

  1. NR_146082.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC134028, AC137630
  2. NR_146083.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC134028, AC137630
  3. NR_146084.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC134028, AC137630
  4. NR_146085.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC134028, AC137630

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    48918821..48986382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533268.1XP_011531570.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

    See identical proteins and their annotated locations for XP_011531570.1

    Conserved Domains (2) summary
    smart00647
    Location:208270
    IBR; In Between Ring fingers
    cd16773
    Location:137190
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  2. XM_011533267.2XP_011531569.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

    See identical proteins and their annotated locations for XP_011531569.1

    Conserved Domains (2) summary
    smart00647
    Location:208270
    IBR; In Between Ring fingers
    cd16773
    Location:137190
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  3. XM_017005536.2XP_016861025.1  E3 ubiquitin-protein ligase ARIH2 isoform X5

    Conserved Domains (3) summary
    smart00647
    Location:136198
    IBR; In Between Ring fingers
    pfam01485
    Location:226258
    IBR; IBR domain, a half RING-finger domain
    cd16773
    Location:65118
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  4. XM_011533271.1XP_011531573.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

    See identical proteins and their annotated locations for XP_011531573.1

    Conserved Domains (2) summary
    smart00647
    Location:136198
    IBR; In Between Ring fingers
    cd16773
    Location:65118
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  5. XM_011533273.1XP_011531575.1  E3 ubiquitin-protein ligase ARIH2 isoform X4

    See identical proteins and their annotated locations for XP_011531575.1

    Conserved Domains (1) summary
    smart00647
    Location:124186
    IBR; In Between Ring fingers
  6. XM_024453308.1XP_024309076.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

    Conserved Domains (2) summary
    smart00647
    Location:208270
    IBR; In Between Ring fingers
    cd16773
    Location:137190
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  7. XM_024453309.1XP_024309077.1  E3 ubiquitin-protein ligase ARIH2 isoform X2

    Conserved Domains (3) summary
    smart00647
    Location:208270
    IBR; In Between Ring fingers
    pfam01485
    Location:298330
    IBR; IBR domain, a half RING-finger domain
    cd16773
    Location:137190
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  8. XM_017005534.1XP_016861023.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

    Conserved Domains (2) summary
    smart00647
    Location:136198
    IBR; In Between Ring fingers
    cd16773
    Location:65118
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  9. XM_024453311.1XP_024309079.1  E3 ubiquitin-protein ligase ARIH2 isoform X7

    Conserved Domains (2) summary
    smart00647
    Location:66128
    IBR; In Between Ring fingers
    cd16773
    Location:148
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  10. XM_024453310.1XP_024309078.1  E3 ubiquitin-protein ligase ARIH2 isoform X6

    Conserved Domains (3) summary
    smart00647
    Location:124186
    IBR; In Between Ring fingers
    pfam01485
    Location:214246
    IBR; IBR domain, a half RING-finger domain
    cd16773
    Location:53106
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  11. XM_017005533.2XP_016861022.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

    Conserved Domains (2) summary
    smart00647
    Location:136198
    IBR; In Between Ring fingers
    cd16773
    Location:65118
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  12. XM_017005535.1XP_016861024.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

    Conserved Domains (2) summary
    smart00647
    Location:136198
    IBR; In Between Ring fingers
    cd16773
    Location:65118
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
  13. XM_011533276.1XP_011531578.1  E3 ubiquitin-protein ligase ARIH2 isoform X8

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