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Arih2 ariadne RBR E3 ubiquitin protein ligase 2 [ Mus musculus (house mouse) ]

Gene ID: 23807, updated on 2-Nov-2024

Summary

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Official Symbol
Arih2provided by MGI
Official Full Name
ariadne RBR E3 ubiquitin protein ligase 2provided by MGI
Primary source
MGI:MGI:1344361
See related
Ensembl:ENSMUSG00000064145 AllianceGenome:MGI:1344361
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARI2; UIP48; TRIAD1
Summary
Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Acts upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in nucleoplasm. Predicted to be part of Cul5-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human ARIH2 (ariadne RBR E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 32.8), thymus adult (RPKM 11.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Arih2 in Genome Data Viewer
Location:
9 F2; 9 59.54 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108480141..108531917, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108602942..108653681, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene DALR anticodon binding domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_25213 Neighboring gene STARR-seq mESC enhancer starr_25214 Neighboring gene WD repeat domain 6 Neighboring gene prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:108551788-108551897 Neighboring gene STARR-seq mESC enhancer starr_25220 Neighboring gene STARR-positive B cell enhancer ABC_E8317 Neighboring gene solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 Neighboring gene protein kinase, cAMP dependent regulatory, type II alpha Neighboring gene STARR-seq mESC enhancer starr_25223 Neighboring gene predicted gene, 24259

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Arih2 regulates Hedgehog signaling through smoothened ubiquitylation and ER-associated degradation. Lv B, et al. J Cell Sci, 2022 Aug 15. PMID 35899529, Free PMC Article
  2. HoxA10 Terminates Emergency Granulopoiesis by Increasing Expression of Triad1. Wang H, et al. J Immunol, 2015 Jun 1. PMID 25895533, Free PMC Article
  3. The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells. Marteijn JA, et al. Blood, 2005 Dec 15. PMID 16118314
  4. HoxA10 influences protein ubiquitination by activating transcription of ARIH2, the gene encoding Triad1. Wang H, et al. J Biol Chem, 2011 May 13. PMID 21454682, Free PMC Article
  5. A novel feed-forward loop between ARIH2 E3-ligase and PABPN1 regulates aging-associated muscle degeneration. Raz V, et al. Am J Pathol, 2014 Apr. PMID 24486325

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arih2 regulates Hedgehog signaling through smoothened ubiquitylation and ER-associated degradation.
    Title: Arih2 regulates Hedgehog signaling through smoothened ubiquitylation and ER-associated degradation.
  2. HOXA10 gene disruption exhibited an overwhelming and fatal emergency granulopoiesis response that was characterized by tissue infiltration with granulocytes, but reversed by re-expression of Triad1 in the bone marrow.
    Title: HoxA10 Terminates Emergency Granulopoiesis by Increasing Expression of Triad1.
  3. essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system
    Title: ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system.
  4. HoxA10 influences protein ubiquitination by activating transcription of ARIH2, the gene encoding Triad1
    Title: HoxA10 influences protein ubiquitination by activating transcription of ARIH2, the gene encoding Triad1.
  5. proteasomal degradation of proteins that are ubiquitinated by Triad1 affects the clonogenic growth of primary myeloid progenitor cells
    Title: The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in developmental cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in developmental cell growth ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in hematopoietic stem cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in hematopoietic stem cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Cul5-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul5-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase ARIH2
Names
ARI-2
RING-type E3 ubiquitin transferase ARIH2
ariadne 2
ariadne homolog 2
protein ariadne-2 homolog
ubcM4-interacting protein 48
NP_001344212.1
NP_001344214.1
NP_001344215.1
NP_001407995.1
NP_035920.1
XP_011241183.1
XP_030100211.1
XP_030100212.1
XP_036010821.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357283.2 → NP_001344212.1  E3 ubiquitin-protein ligase ARIH2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same isoform (a).
    Source sequence(s)
    CT571271
    Consensus CDS
    CCDS23534.1
    UniProtKB/Swiss-Prot
    Q9Z1K6
    UniProtKB/TrEMBL
    Q3TK92
    Conserved Domains (3) summary
    smart00647
    Location:207 → 269
    IBR; In Between Ring fingers
    cd16773
    Location:136 → 189
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:297 → 329
    IBR; IBR domain, a half RING-finger domain

  2. NM_001357285.1 → NP_001344214.1  E3 ubiquitin-protein ligase ARIH2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same isoform (a).
    Source sequence(s)
    AK167104, BC051998, CT571271
    Consensus CDS
    CCDS23534.1
    UniProtKB/Swiss-Prot
    Q9Z1K6
    UniProtKB/TrEMBL
    Q3TK92
    Conserved Domains (3) summary
    smart00647
    Location:207 → 269
    IBR; In Between Ring fingers
    cd16773
    Location:136 → 189
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:297 → 329
    IBR; IBR domain, a half RING-finger domain

  3. NM_001357286.2 → NP_001344215.1  E3 ubiquitin-protein ligase ARIH2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.z
    Source sequence(s)
    CT571271
    Conserved Domains (3) summary
    smart00647
    Location:136 → 198
    IBR; In Between Ring fingers
    cd16773
    Location:65 → 118
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:226 → 258
    IBR; IBR domain, a half RING-finger domain

  4. NM_001421066.1 → NP_001407995.1  E3 ubiquitin-protein ligase ARIH2 isoform b

    Status: VALIDATED

    Source sequence(s)
    CT571271

  5. NM_011790.6 → NP_035920.1  E3 ubiquitin-protein ligase ARIH2 isoform a

    See identical proteins and their annotated locations for NP_035920.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1-3 all encode the same isoform (a).
    Source sequence(s)
    CT571271
    Consensus CDS
    CCDS23534.1
    UniProtKB/Swiss-Prot
    Q9Z1K6
    UniProtKB/TrEMBL
    Q3TK92
    Related
    ENSMUSP00000013338.9, ENSMUST00000013338.14
    Conserved Domains (3) summary
    smart00647
    Location:207 → 269
    IBR; In Between Ring fingers
    cd16773
    Location:136 → 189
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:297 → 329
    IBR; IBR domain, a half RING-finger domain

RNA

  1. NR_151664.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    CT571271

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    108480141..108531917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244352.1 → XP_030100212.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

    UniProtKB/Swiss-Prot
    Q9Z1K6
    UniProtKB/TrEMBL
    Q3TK92
    Conserved Domains (3) summary
    smart00647
    Location:207 → 269
    IBR; In Between Ring fingers
    cd16773
    Location:136 → 189
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:297 → 329
    IBR; IBR domain, a half RING-finger domain

  2. XM_030244351.2 → XP_030100211.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

    UniProtKB/Swiss-Prot
    Q9Z1K6
    UniProtKB/TrEMBL
    Q3TK92
    Conserved Domains (3) summary
    smart00647
    Location:207 → 269
    IBR; In Between Ring fingers
    cd16773
    Location:136 → 189
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:297 → 329
    IBR; IBR domain, a half RING-finger domain

  3. XM_036154928.1 → XP_036010821.1  E3 ubiquitin-protein ligase ARIH2 isoform X2

    Conserved Domains (3) summary
    smart00647
    Location:136 → 198
    IBR; In Between Ring fingers
    cd16773
    Location:65 → 118
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:226 → 258
    IBR; IBR domain, a half RING-finger domain

  4. XM_011242881.4 → XP_011241183.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

    UniProtKB/TrEMBL
    A0A0A6YXB0
    Related
    ENSMUSP00000141914.2, ENSMUST00000193190.6
    Conserved Domains (2) summary
    smart00647
    Location:207 → 269
    IBR; In Between Ring fingers
    cd16773
    Location:136 → 189
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z1K6.1 GenPept UniProtKB/Swiss-Prot:Q9Z1K6

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