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    Amn1 antagonist of mitotic exit network 1 [ Mus musculus (house mouse) ]

    Gene ID: 232566, updated on 8-Feb-2024

    Summary

    Official Symbol
    Amn1provided by MGI
    Official Full Name
    antagonist of mitotic exit network 1provided by MGI
    Primary source
    MGI:MGI:2442933
    See related
    Ensembl:ENSMUSG00000068250 AllianceGenome:MGI:2442933
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A230083D09; 5830467E07Rik; C730024G19Rik
    Summary
    Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in Sertoli cell and brain. Orthologous to human AMN1 (antagonist of mitotic exit network 1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 5.0), CNS E18 (RPKM 4.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Amn1 in Genome Data Viewer
    Location:
    6 G3; 6 78.81 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (149059075..149090210, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (149157261..149188712, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene DENN domain containing 5B Neighboring gene STARR-seq mESC enhancer starr_17854 Neighboring gene predicted gene, 23462 Neighboring gene STARR-positive B cell enhancer ABC_E8834 Neighboring gene STARR-seq mESC enhancer starr_17857 Neighboring gene STARR-positive B cell enhancer mm9_chr6:149081472-149081773 Neighboring gene electron transfer flavoprotein beta subunit lysine methyltransferase Neighboring gene STARR-seq mESC enhancer starr_17859 Neighboring gene STARR-seq mESC enhancer starr_17860 Neighboring gene STARR-seq mESC enhancer starr_17861 Neighboring gene STARR-seq mESC enhancer starr_17862 Neighboring gene STARR-seq mESC enhancer starr_17863 Neighboring gene STARR-seq mESC enhancer starr_17864 Neighboring gene STARR-seq mESC enhancer starr_17865 Neighboring gene STARR-seq mESC enhancer starr_17866 Neighboring gene STARR-seq mESC enhancer starr_17867 Neighboring gene STARR-seq mESC enhancer starr_17868 Neighboring gene STARR-seq mESC enhancer starr_17869 Neighboring gene STARR-positive B cell enhancer ABC_E8835 Neighboring gene retroelement silencing factor 1 Neighboring gene predicted gene, 38930

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cargo receptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cobalamin transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in microvillus membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in microvillus membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein AMN1 homolog
    Names
    antagonist of mitotic exit network 1 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113424.1NP_001106895.1  protein AMN1 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC128664, AC132412
      Consensus CDS
      CCDS51961.1
      UniProtKB/Swiss-Prot
      B8JKV0
      Related
      ENSMUSP00000107160.2, ENSMUST00000111535.8
      Conserved Domains (2) summary
      cd09293
      Location:37257
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:6386
      LRR_AMN1; leucine-rich repeat [structural motif]
    2. NM_001356344.1NP_001343273.1  protein AMN1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC128664, AC132412
      Consensus CDS
      CCDS90142.1
      UniProtKB/TrEMBL
      B8JKU8
      Related
      ENSMUSP00000092957.4, ENSMUST00000095319.10
      Conserved Domains (2) summary
      sd00034
      Location:2043
      LRR_AMN1; leucine-rich repeat [structural motif]
      cl28166
      Location:1214
      AMN1; Antagonist of mitotic exit network protein 1
    3. NM_001381983.1NP_001368912.1  protein AMN1 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC128664, AC132412
      Conserved Domains (2) summary
      cd09293
      Location:29249
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:5578
      LRR_AMN1; leucine-rich repeat [structural motif]

    RNA

    1. NR_153963.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site and lacks two exons in the 5' region compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding sequence found in variant 1.
      Source sequence(s)
      AC128664, AK038995
      Related
      ENSMUST00000150610.8
    2. NR_167758.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC128664, AC132412
    3. NR_167759.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC128664, AC132412
    4. NR_167760.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC128664, AC132412
    5. NR_167761.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC128664, AC132412
    6. NR_167762.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC128664, AC132412
    7. NR_167763.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC128664, AC132412

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      149059075..149090210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)