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AMN1 antagonist of mitotic exit network 1 homolog [ Homo sapiens (human) ]

Gene ID: 196394, updated on 11-Sep-2019

Summary

Official Symbol
AMN1provided by HGNC
Official Full Name
antagonist of mitotic exit network 1 homologprovided by HGNC
Primary source
HGNC:HGNC:27281
See related
Ensembl:ENSG00000151743
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 7.2), brain (RPKM 4.4) and 23 other tissues See more
Orthologs

Genomic context

See AMN1 in Genome Data Viewer
Location:
12p11.21
Exon count:
12
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (31671137..31729174, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (31824071..31882108, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene DENND5B antisense RNA 1 Neighboring gene ribosomal protein L31 pseudogene 50 Neighboring gene adenylate kinase 4 pseudogene 3 Neighboring gene electron transfer flavoprotein subunit beta lysine methyltransferase Neighboring gene uncharacterized LOC105369722 Neighboring gene stathmin 1 pseudogene 1 Neighboring gene uncharacterized LOC105369724 Neighboring gene Sharpr-MPRA regulatory region 4305 Neighboring gene interferon induced transmembrane protein 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: results of a genome-wide association study.
NHGRI GWA Catalog

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113402.2NP_001106873.1  protein AMN1 homolog isoform 1

    See identical proteins and their annotated locations for NP_001106873.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC045831, BC067906
    Consensus CDS
    CCDS44858.1
    UniProtKB/Swiss-Prot
    Q8IY45
    Related
    ENSP00000281471.6, ENST00000281471.11
    Conserved Domains (2) summary
    cd09293
    Location:37257
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:6386
    LRR_AMN1; leucine-rich repeat [structural motif]
  2. NM_001278411.1NP_001265340.1  protein AMN1 homolog isoform 2

    See identical proteins and their annotated locations for NP_001265340.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site, which results in a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform 2.
    Source sequence(s)
    BC037897, BC067906, DC325581, DC394802
    Consensus CDS
    CCDS61089.1
    UniProtKB/Swiss-Prot
    Q8IY45
    Related
    ENSP00000438990.1, ENST00000535408.5
    Conserved Domains (2) summary
    cd09293
    Location:19239
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:4568
    LRR_AMN1; leucine-rich repeat [structural motif]
  3. NM_001278412.1NP_001265341.1  protein AMN1 homolog isoform 2

    See identical proteins and their annotated locations for NP_001265341.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has two additional exons in the 5' region, which results in a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform 2.
    Source sequence(s)
    AK123033, AK302112, BC037897, BC067906, DC394802
    Consensus CDS
    CCDS61089.1
    UniProtKB/Swiss-Prot
    Q8IY45
    Related
    ENSP00000440967.1, ENST00000536761.5
    Conserved Domains (2) summary
    cd09293
    Location:19239
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:4568
    LRR_AMN1; leucine-rich repeat [structural motif]

RNA

  1. NR_103522.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has alternate exons in the 5' region and an additional exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK123033, AK311249, BC037897, BC067906, DC394802
  2. NR_103523.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an exon in the 5' region, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the 5' coding region found in variant 1.
    Source sequence(s)
    AK123033, AK311214, BC037897, BC067906, DC394802

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    31671137..31729174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018965.2XP_016874454.1  protein AMN1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q8IY45
    Conserved Domains (2) summary
    cd09293
    Location:19239
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:4568
    LRR_AMN1; leucine-rich repeat [structural motif]
  2. XM_017018963.2XP_016874452.1  protein AMN1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q8IY45
    Conserved Domains (2) summary
    cd09293
    Location:19239
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:4568
    LRR_AMN1; leucine-rich repeat [structural motif]
  3. XM_017018964.1XP_016874453.1  protein AMN1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q8IY45
    Conserved Domains (2) summary
    cd09293
    Location:19239
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:4568
    LRR_AMN1; leucine-rich repeat [structural motif]
  4. XM_006719054.3XP_006719117.1  protein AMN1 homolog isoform X3

    Conserved Domains (2) summary
    cd09293
    Location:9208
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:1437
    LRR_AMN1; leucine-rich repeat [structural motif]
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