U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    TNIK TRAF2 and NCK interacting kinase [ Homo sapiens (human) ]

    Gene ID: 23043, updated on 5-May-2024

    Summary

    Official Symbol
    TNIKprovided by HGNC
    Official Full Name
    TRAF2 and NCK interacting kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:30765
    See related
    Ensembl:ENSG00000154310 MIM:610005; AllianceGenome:HGNC:30765
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRT54
    Summary
    Wnt signaling plays important roles in carcinogenesis and embryonic development. The protein encoded by this gene is a serine/threonine kinase that functions as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]
    Expression
    Broad expression in brain (RPKM 10.5), small intestine (RPKM 7.1) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TNIK in Genome Data Viewer
    Location:
    3q26.2-q26.31
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (171058414..171460408, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (173842724..174244711, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (170776203..171178197, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, U1 small nuclear 70, pseudogene Neighboring gene solute carrier family 2 member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14889 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:170779459-170780037 Neighboring gene MPRA-validated peak4922 silencer Neighboring gene uncharacterized LOC105374216 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:170834472-170835140 Neighboring gene microRNA 569 Neighboring gene Sharpr-MPRA regulatory region 1564 Neighboring gene Sharpr-MPRA regulatory region 12227 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14890 Neighboring gene NANOG hESC enhancer GRCh37_chr3:170904542-170905069 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20808 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:170924049-170924658 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:170952794-170952983 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20809 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20810 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20813 Neighboring gene VISTA enhancer hs2120 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20814 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:171101812-171102358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20815 Neighboring gene uncharacterized LOC124906303 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14893 Neighboring gene uncharacterized LOC102724479 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:171178895-171179395 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14894 Neighboring gene CRISPRi-validated cis-regulatory element chr3.4898 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:171206252-171207451 Neighboring gene RNA, U6 small nuclear 348, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Intellectual disability, autosomal recessive 54
    MedGen: C4310755 OMIM: 617028 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.
    EBI GWAS Catalog
    Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in microvillus assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of dendrite morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to organonitrogen compound IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density, intracellular component IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    TRAF2 and NCK-interacting protein kinase
    NP_001155032.1
    NP_001155033.1
    NP_001155034.1
    NP_001155035.1
    NP_001155036.1
    NP_001155037.1
    NP_001155038.1
    NP_055843.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_054934.2 RefSeqGene

      Range
      5003..406994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001161560.3NP_001155032.1  TRAF2 and NCK-interacting protein kinase isoform 2

      See identical proteins and their annotated locations for NP_001155032.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the middle portion of the coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      AC026315, AC078793, AC092919, AC137517
      Consensus CDS
      CCDS54679.1
      UniProtKB/Swiss-Prot
      Q9UKE5
      Related
      ENSP00000284483.8, ENST00000284483.12
      Conserved Domains (2) summary
      smart00036
      Location:10341332
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
    2. NM_001161561.3NP_001155033.1  TRAF2 and NCK-interacting protein kinase isoform 3

      See identical proteins and their annotated locations for NP_001155033.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the middle portion of the coding region compared to variant 1. This results in a shorter protein (isoform 3) compared to isoform 1.
      Source sequence(s)
      AC026315, AC078793, AC092919, AC137517
      Consensus CDS
      CCDS54676.1
      UniProtKB/Swiss-Prot
      Q9UKE5
      Related
      ENSP00000349880.5, ENST00000357327.9
      Conserved Domains (2) summary
      smart00036
      Location:10131311
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
    3. NM_001161562.3NP_001155034.1  TRAF2 and NCK-interacting protein kinase isoform 4

      See identical proteins and their annotated locations for NP_001155034.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two in-frame exons in the middle portion of the coding region compared to variant 1. This results in a shorter protein (isoform 4) compared to isoform 1.
      Source sequence(s)
      AC026315, AC078793, AC092919, AC137517
      Consensus CDS
      CCDS54675.1
      UniProtKB/Swiss-Prot
      Q9UKE5
      Related
      ENSP00000419990.1, ENST00000470834.5
      Conserved Domains (2) summary
      smart00036
      Location:10051303
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
    4. NM_001161563.3NP_001155035.1  TRAF2 and NCK-interacting protein kinase isoform 5

      See identical proteins and their annotated locations for NP_001155035.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an in-frame exon in the middle portion of the coding region compared to variant 1. This results in a shorter protein (isoform 5) compared to isoform 1.
      Source sequence(s)
      AC026315, AC078793, AC092919, AC137517
      Consensus CDS
      CCDS54678.1
      UniProtKB/Swiss-Prot
      Q9UKE5
      Related
      ENSP00000418378.1, ENST00000488470.5
      Conserved Domains (3) summary
      smart00036
      Location:9871285
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06637
      Location:18313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
    5. NM_001161564.3NP_001155036.1  TRAF2 and NCK-interacting protein kinase isoform 6

      See identical proteins and their annotated locations for NP_001155036.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks two in-frame exons in the middle portion of the coding region compared to variant 1. This results in a shorter protein (isoform 6) compared to isoform 1.
      Source sequence(s)
      AC026315, AC078793, AC092919, AC137517
      Consensus CDS
      CCDS54677.1
      UniProtKB/Swiss-Prot
      Q9UKE5
      Related
      ENSP00000418916.1, ENST00000460047.5
      Conserved Domains (3) summary
      smart00036
      Location:9791277
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06637
      Location:18313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
    6. NM_001161565.3NP_001155037.1  TRAF2 and NCK-interacting protein kinase isoform 7

      See identical proteins and their annotated locations for NP_001155037.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks two in-frame exons in the middle portion of the coding region compared to variant 1. This results in a shorter protein (isoform 7) compared to isoform 1.
      Source sequence(s)
      AC026315, AC078793, AC092919, AC137517
      Consensus CDS
      CCDS54674.1
      UniProtKB/Swiss-Prot
      Q9UKE5
      Related
      ENSP00000345352.6, ENST00000341852.10
      Conserved Domains (3) summary
      smart00036
      Location:9581256
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06637
      Location:18313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
    7. NM_001161566.3NP_001155038.1  TRAF2 and NCK-interacting protein kinase isoform 8

      See identical proteins and their annotated locations for NP_001155038.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks three in-frame exons in the middle portion of the coding region compared to variant 1. This results in a shorter protein (isoform 8) compared to isoform 1.
      Source sequence(s)
      AC026315, AC078793, AC092919, AC137517
      Consensus CDS
      CCDS54673.1
      UniProtKB/Swiss-Prot
      Q9UKE5
      Related
      ENSP00000418156.1, ENST00000475336.5
      Conserved Domains (3) summary
      smart00036
      Location:9501248
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06637
      Location:18313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
    8. NM_015028.4NP_055843.1  TRAF2 and NCK-interacting protein kinase isoform 1

      See identical proteins and their annotated locations for NP_055843.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC026315, AC078793, AC092919, AC137517
      Consensus CDS
      CCDS46956.1
      UniProtKB/Swiss-Prot
      A7E2A3, A8K4U1, D3DNQ6, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4, Q9UKE5
      Related
      ENSP00000399511.2, ENST00000436636.7
      Conserved Domains (2) summary
      smart00036
      Location:10421340
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    RNA

    1. NR_027767.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AK291056, AW296249, BC018093, BG209385
      Related
      ENST00000465393.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      171058414..171460408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      173842724..174244711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)