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    HSPA4L heat shock protein family A (Hsp70) member 4 like [ Homo sapiens (human) ]

    Gene ID: 22824, updated on 7-Apr-2024

    Summary

    Official Symbol
    HSPA4Lprovided by HGNC
    Official Full Name
    heat shock protein family A (Hsp70) member 4 likeprovided by HGNC
    Primary source
    HGNC:HGNC:17041
    See related
    Ensembl:ENSG00000164070 MIM:619077; AllianceGenome:HGNC:17041
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APG1; APG-1; HSPH3; Osp94
    Summary
    The protein encoded by this gene is heat shock inducible and may act as a chaperone. The encoded protein can protect the heat-shocked cell against the harmful effects of aggregated proteins. This gene is highly expressed in leukemia cells and may be a good target for therapeutic intervention. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
    Expression
    Biased expression in testis (RPKM 41.4), esophagus (RPKM 5.8) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    4q28.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (127781796..127840733)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (131084803..131143731)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (128702951..128761888)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:128553760-128554299 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:128576502-128577102 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:128577103-128577701 Neighboring gene inturned planar cell polarity protein Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:128607842-128609041 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:128629462-128630661 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:128651275-128651432 Neighboring gene solute carrier family 25 member 31 Neighboring gene uncharacterized LOC105377414 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15671 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15672 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15673 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15674 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:128703547-128704539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21886 Neighboring gene SOSS complex subunit C-like Neighboring gene ribosomal protein L21 pseudogene 53 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:128767199-128767740 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_73803 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21887 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_73815 Neighboring gene RNA, U6 small nuclear 583, pseudogene Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_73859 Neighboring gene polo like kinase 4 Neighboring gene major facilitator superfamily domain containing 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15677 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:128886145-128886760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15678 Neighboring gene abhydrolase domain containing 18

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to unfolded protein ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    heat shock 70 kDa protein 4L
    Names
    HSPA4-like protein
    heat shock 70 kDa protein 4-like protein
    heat shock 70-related protein APG-1
    heat shock 70kDa protein 4-like
    heat shock protein (hsp110 family)
    heat-shock protein family A member 4-like protein
    osmotic stress protein 94
    testis tissue sperm-binding protein Li 64n

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317381.2NP_001304310.1  heat shock 70 kDa protein 4L isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is longer at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC093591, AK303053, BC040560, BM679019
      UniProtKB/TrEMBL
      B4DZR0
      Conserved Domains (2) summary
      cd11738
      Location:33415
      HSPA4L_NBD; Nucleotide-binding domain of HSPA4L
      pfam00012
      Location:34725
      HSP70; Hsp70 protein
    2. NM_001317382.2NP_001304311.1  heat shock 70 kDa protein 4L isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate first exon compared to variant 1.The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC093591, AK302115, BC040560, BM679019, DB086945
      Consensus CDS
      CCDS82953.1
      UniProtKB/TrEMBL
      B4DXT2, E9PDE8
      Related
      ENSP00000425645.1, ENST00000505726.1
      Conserved Domains (2) summary
      pfam00012
      Location:11668
      HSP70; Hsp70 protein
      cl17037
      Location:11358
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    3. NM_001317383.2NP_001304312.1  heat shock 70 kDa protein 4L isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC093591, AK307464, BC040560, BM679019
      UniProtKB/TrEMBL
      Q53ZP9
      Conserved Domains (2) summary
      pfam00012
      Location:3653
      HSP70; Hsp70 protein
      cl17037
      Location:2343
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    4. NM_014278.4NP_055093.2  heat shock 70 kDa protein 4L isoform 1

      See identical proteins and their annotated locations for NP_055093.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AC093591, BC040560, BM679019
      Consensus CDS
      CCDS3734.1
      UniProtKB/Swiss-Prot
      A2ICT2, O95757, Q4W5M5, Q8IWA2
      UniProtKB/TrEMBL
      A0A140VKE7, Q53ZP9
      Related
      ENSP00000296464.3, ENST00000296464.9
      Conserved Domains (1) summary
      cd11738
      Location:2384
      HSPA4L_NBD; Nucleotide-binding domain of HSPA4L

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      127781796..127840733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531745.4XP_011530047.1  heat shock 70 kDa protein 4L isoform X1

      UniProtKB/TrEMBL
      B3KNM0
      Conserved Domains (2) summary
      PRK13929
      Location:4375
      PRK13929; rod-share determining protein MreBH; Provisional
      cd11738
      Location:2384
      HSPA4L_NBD; Nucleotide-binding domain of HSPA4L

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      131084803..131143731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349269.1XP_054205244.1  heat shock 70 kDa protein 4L isoform X1