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Hspa4l heat shock protein 4 like [ Mus musculus (house mouse) ]

Gene ID: 18415, updated on 1-Mar-2024

Summary

Official Symbol
Hspa4lprovided by MGI
Official Full Name
heat shock protein 4 likeprovided by MGI
Primary source
MGI:MGI:107422
See related
Ensembl:ENSMUSG00000025757 AllianceGenome:MGI:107422
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
94kDa; APG-1; Osp94
Summary
Predicted to enable ATP binding activity. Predicted to be involved in protein folding and response to unfolded protein. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; liver and biliary system; nervous system; and sensory organ. Orthologous to human HSPA4L (heat shock protein family A (Hsp70) member 4 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 20.6), cerebellum adult (RPKM 14.3) and 16 other tissues See more
Orthologs
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Genomic context

See Hspa4l in Genome Data Viewer
Location:
3 B; 3 19.51 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (40698664..40750538)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (40744500..40796103)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr3:40439532-40439833 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:40457146-40457255 Neighboring gene inturned planar cell polarity protein Neighboring gene solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 Neighboring gene STARR-seq mESC enhancer starr_07472 Neighboring gene STARR-positive B cell enhancer ABC_E9547 Neighboring gene polo like kinase 4 Neighboring gene major facilitator superfamily domain containing 8 Neighboring gene STARR-positive B cell enhancer ABC_E1617

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC117843

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
heat shock 70 kDa protein 4L
Names
heat shock 70-related protein APG-1
heat shock 70kDa protein 4 like
osmotic stress protein 94

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410463.1NP_001397392.1  heat shock 70 kDa protein 4L isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC160757
    UniProtKB/Swiss-Prot
    P48722, P97854, Q3TQN2, Q3UNG4, Q8BQD0, Q8CC45, Q91X29
  2. NM_001410464.1NP_001397393.1  heat shock 70 kDa protein 4L isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC160757
    UniProtKB/Swiss-Prot
    P48722, P97854, Q3TQN2, Q3UNG4, Q8BQD0, Q8CC45, Q91X29
  3. NM_001410465.1NP_001397394.1  heat shock 70 kDa protein 4L isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC160757
  4. NM_011020.4NP_035150.3  heat shock 70 kDa protein 4L isoform 1

    See identical proteins and their annotated locations for NP_035150.3

    Status: VALIDATED

    Source sequence(s)
    AC160757
    Consensus CDS
    CCDS17327.1
    UniProtKB/Swiss-Prot
    P48722, P97854, Q3TQN2, Q3UNG4, Q8BQD0, Q8CC45, Q91X29
    Related
    ENSMUSP00000145468.2, ENSMUST00000204702.3
    Conserved Domains (1) summary
    cd11738
    Location:2384
    HSPA4L_NBD; Nucleotide-binding domain of HSPA4L

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    40698664..40750538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)