U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Ube2i ubiquitin-conjugating enzyme E2I [ Mus musculus (house mouse) ]

    Gene ID: 22196, updated on 11-Apr-2024

    Summary

    Official Symbol
    Ube2iprovided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2Iprovided by MGI
    Primary source
    MGI:MGI:107365
    See related
    Ensembl:ENSMUSG00000015120 AllianceGenome:MGI:107365
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UBC9; Ubce9; Ubce2i; 5830467E05Rik
    Summary
    Enables HLH domain binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of I-kappaB kinase/NF-kappaB signaling. Located in nuclear body. Is expressed in several structures, including early embryo; forebrain; forelimb bud; limb; and oocyte. Orthologous to human UBE2I (ubiquitin conjugating enzyme E2 I). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 68.8), whole brain E14.5 (RPKM 68.0) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ube2i in Genome Data Viewer
    Location:
    17 A3.3; 17 12.53 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25479484..25494965, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25260510..25275799, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene N-acetylglucosamine-1-phosphotransferase, gamma subunit Neighboring gene TSR3 20S rRNA accumulation Neighboring gene BAI1-associated protein 3 Neighboring gene microRNA 3547 Neighboring gene STARR-positive B cell enhancer ABC_E8659 Neighboring gene predicted gene, 17801 Neighboring gene serine protease 34 Neighboring gene predicted gene, 25921

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables HLH domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RING-like zinc finger domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SUMO conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SUMO conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables bHLH transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small protein activating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coregulator binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear export EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in nuclear export ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein modification process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SUMO ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SUMO ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transferase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    SUMO-conjugating enzyme UBC9
    Names
    RING-type E3 SUMO transferase UBC9
    SUMO-protein ligase
    ubiquitin carrier protein 9
    ubiquitin carrier protein I
    ubiquitin-protein ligase I
    NP_001171080.1
    NP_001171081.1
    NP_001344623.1
    NP_035795.1
    XP_006524112.1
    XP_036016378.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177609.1NP_001171080.1  SUMO-conjugating enzyme UBC9

      See identical proteins and their annotated locations for NP_001171080.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK150575, AK166657, AK166930
      Consensus CDS
      CCDS28513.1
      UniProtKB/Swiss-Prot
      P63280, Q6RUT3
      Related
      ENSMUSP00000134261.2, ENSMUST00000173084.9
      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme
    2. NM_001177610.1NP_001171081.1  SUMO-conjugating enzyme UBC9

      See identical proteins and their annotated locations for NP_001171081.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 2. Variants 1-4 encode the same protein.
      Source sequence(s)
      AC122454, AK166930
      Consensus CDS
      CCDS28513.1
      UniProtKB/Swiss-Prot
      P63280, Q6RUT3
      Related
      ENSMUSP00000134350.2, ENSMUST00000174031.9
      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme
    3. NM_001357694.1NP_001344623.1  SUMO-conjugating enzyme UBC9

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 2. Variants 1-4 encode the same protein.
      Source sequence(s)
      AC122454, CD776278
      Consensus CDS
      CCDS28513.1
      UniProtKB/Swiss-Prot
      P63280, Q6RUT3
      Related
      ENSMUSP00000134161.3, ENSMUST00000173621.9
      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme
    4. NM_011665.4NP_035795.1  SUMO-conjugating enzyme UBC9

      See identical proteins and their annotated locations for NP_035795.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK005058, BY074880
      Consensus CDS
      CCDS28513.1
      UniProtKB/Swiss-Prot
      P63280, Q6RUT3
      Related
      ENSMUSP00000134491.2, ENSMUST00000173713.9
      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25479484..25494965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524049.5XP_006524112.1  SUMO-conjugating enzyme UBC9 isoform X1

      See identical proteins and their annotated locations for XP_006524112.1

      UniProtKB/Swiss-Prot
      P63280, Q6RUT3
      Related
      ENSMUSP00000055714.10, ENSMUST00000049911.17
      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme
    2. XM_036160485.1XP_036016378.1  SUMO-conjugating enzyme UBC9 isoform X1

      UniProtKB/Swiss-Prot
      P63280, Q6RUT3
      Related
      ENSMUSP00000159860.1, ENSMUST00000249684.1
      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme