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    Ube2i ubiquitin-conjugating enzyme E2I [ Mus musculus (house mouse) ]

    Gene ID: 22196, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ube2iprovided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2Iprovided by MGI
    Primary source
    MGI:MGI:107365
    See related
    Ensembl:ENSMUSG00000015120
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UBC9; Ubce9; Ubce2i; 5830467E05Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 68.8), whole brain E14.5 (RPKM 68.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ube2i in Genome Data Viewer
    Location:
    17; 17 A3.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (25260510..25274310, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (25397456..25411255, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene N-acetylglucosamine-1-phosphotransferase, gamma subunit Neighboring gene TSR3 20S rRNA accumulation Neighboring gene BAI1-associated protein 3 Neighboring gene microRNA 3547 Neighboring gene predicted gene, 17801 Neighboring gene protease, serine 34 Neighboring gene protease, serine 28

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    HLH domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    RING-like zinc finger domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    SUMO conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SUMO conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    bHLH transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    small protein activating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cellular protein modification process TAS
    Traceable Author Statement
    more info
    PubMed 
    chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of intracellular steroid hormone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    PML body ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    sumoylated E2 ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    synapse ISO
    Inferred from Sequence Orthology
    more info
     
    transferase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    SUMO-conjugating enzyme UBC9
    Names
    RING-type E3 SUMO transferase UBC9
    SUMO-protein ligase
    ubiquitin carrier protein 9
    ubiquitin carrier protein I
    ubiquitin-protein ligase I
    NP_001171080.1
    NP_001171081.1
    NP_035795.1
    XP_006524111.1
    XP_006524112.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177609.1NP_001171080.1  SUMO-conjugating enzyme UBC9

      See identical proteins and their annotated locations for NP_001171080.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK150575, AK166657, AK166930
      Consensus CDS
      CCDS28513.1
      UniProtKB/Swiss-Prot
      P63280
      Related
      ENSMUSP00000134169.1, ENSMUST00000172618.7
      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme
    2. NM_001177610.1NP_001171081.1  SUMO-conjugating enzyme UBC9

      See identical proteins and their annotated locations for NP_001171081.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 2. Variants 1-4 encode the same protein.
      Source sequence(s)
      AC122454, AK166930
      Consensus CDS
      CCDS28513.1
      UniProtKB/Swiss-Prot
      P63280
      Related
      ENSMUSP00000134350.1, ENSMUST00000174031.7
      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme
    3. NM_001357694.1NP_001344623.1  SUMO-conjugating enzyme UBC9

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 2. Variants 1-4 encode the same protein.
      Source sequence(s)
      AC122454, CD776278
      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme
    4. NM_011665.4NP_035795.1  SUMO-conjugating enzyme UBC9

      See identical proteins and their annotated locations for NP_035795.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK005058, BY074880
      Consensus CDS
      CCDS28513.1
      UniProtKB/Swiss-Prot
      P63280
      Related
      ENSMUSP00000134491.1, ENSMUST00000173713.7
      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      25260510..25274310 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524049.3XP_006524112.1  SUMO-conjugating enzyme UBC9 isoform X1

      See identical proteins and their annotated locations for XP_006524112.1

      UniProtKB/Swiss-Prot
      P63280
      Related
      ENSMUSP00000055714.9, ENSMUST00000049911.15
      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme
    2. XM_006524048.3XP_006524111.1  SUMO-conjugating enzyme UBC9 isoform X1

      UniProtKB/Swiss-Prot
      P63280
      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme
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