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    ADGRF4 adhesion G protein-coupled receptor F4 [ Homo sapiens (human) ]

    Gene ID: 221393, updated on 22-Sep-2022

    Summary

    Official Symbol
    ADGRF4provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor F4provided by HGNC
    Primary source
    HGNC:HGNC:19011
    See related
    Ensembl:ENSG00000153294 MIM:614268; AllianceGenome:HGNC:19011
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGR18; GPR115
    Summary
    Sequence analysis of this gene suggests that it is encodes a member of the superfamily of G protein-couple receptors. G protein-coupled receptors typically contain seven hydrophobic transmembrane domains, interact with guanine nucleotide binding regulatory proteins, and detect molecules outside the cell and act to transduce these signals into intracellular responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016]
    Expression
    Biased expression in skin (RPKM 17.6), esophagus (RPKM 6.4) and 3 other tissues See more
    Orthologs
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    Genomic context

    See ADGRF4 in Genome Data Viewer
    Location:
    6p12.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (47698580..47722014)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (47540367..47563797)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (47666316..47689750)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene CD2 associated protein Neighboring gene DnaJ heat shock protein family (Hsp40) member C17 pseudogene Neighboring gene adhesion G protein-coupled receptor F2 Neighboring gene RN7SK pseudogene 116 Neighboring gene ribosomal protein L27a pseudogene 7 Neighboring gene opsin 5 Neighboring gene RNA, U1 small nuclear 105, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: ADGRF2

    Homology

    Clone Names

    • FLJ38076

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    adhesion G protein-coupled receptor F4
    Names
    G-protein coupled receptor PGR18
    probable G-protein coupled receptor 115
    seven transmembrane helix receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052799.1 RefSeqGene

      Range
      17682..41158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001347855.2NP_001334784.1  adhesion G protein-coupled receptor F4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK095395, AY140957, BU683873
      Consensus CDS
      CCDS4922.2
      UniProtKB/Swiss-Prot
      Q8IXE6, Q8IZF3
      Related
      ENSP00000328319.3, ENST00000327753.7
    2. NM_153838.5NP_722580.3  adhesion G protein-coupled receptor F4 precursor

      See identical proteins and their annotated locations for NP_722580.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AY255556, BU683873, DB313938, DQ315370
      Consensus CDS
      CCDS4922.2
      UniProtKB/Swiss-Prot
      Q8IXE6, Q8IZF3
      Related
      ENSP00000283303.2, ENST00000283303.3
      Conserved Domains (2) summary
      pfam01825
      Location:347390
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:400648
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      47698580..47722014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      47540367..47563797
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)