Mis18bp1 MIS18 binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mis18bp1provided by MGI
Official Full Name: MIS18 binding protein 1provided by MGI
Primary source: MGI:MGI:2145099
See related: Ensembl:ENSMUSG00000047534 AllianceGenome:MGI:2145099
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Knl2; mKIAA1903; 6720403H11
Summary: Predicted to enable DNA binding activity. Predicted to be involved in cell division. Part of CENP-A recruiting complex. Is expressed in cerebral cortex ventricular layer; midbrain ventricular layer; nephrogenic zone; olfactory cortex ventricular layer; and telencephalon ventricular layer. Orthologous to human MIS18BP1 (MIS18 binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E11.5 (RPKM 12.0), liver E14 (RPKM 9.4) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C1; 12 27.21 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (65179508..65219363, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (65132734..65172581, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CENP-C works as an important factor for centromeric M18BP1 recruitment
Title: CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CENP-A recruiting complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in chromosome, centromeric region	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mis18-binding protein 1

Names: kinetochore-associated protein KNL-2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419213.1 → NP_001406142.1 mis18-binding protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC159621, AC159885
NM_172578.3 → NP_766166.2 mis18-binding protein 1 isoform 1

See identical proteins and their annotated locations for NP_766166.2

Status: VALIDATED

Source sequence(s)

AC159621, AC159885

Consensus CDS

CCDS25942.1

UniProtKB/Swiss-Prot

Q571G6, Q80WQ8, Q8BPR7, Q8CBB5, Q8CG92

UniProtKB/TrEMBL

Q8BS57

Related

ENSMUSP00000052109.9, ENSMUST00000052201.9

Conserved Domains (3) summary

smart00717
Location:744 → 788

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:745 → 788

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam09133
Location:338 → 425

SANTA; SANTA (SANT Associated)

RNA

NR_185035.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC159621, AC159885
NR_185036.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC159621, AC159885

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

65179508..65219363 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157309.1 → XP_036013202.1 mis18-binding protein 1 isoform X1

UniProtKB/TrEMBL

Q8K3D2

Conserved Domains (1) summary

cd00167
Location:143 → 186

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...