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MIS18BP1 MIS18 binding protein 1 [ Homo sapiens (human) ]

Gene ID: 55320, updated on 9-Dec-2018

Summary

Official Symbol
MIS18BP1provided by HGNC
Official Full Name
MIS18 binding protein 1provided by HGNC
Primary source
HGNC:HGNC:20190
See related
Ensembl:ENSG00000129534 MIM:618139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KNL2; M18BP1; C14orf106; HSA242977
Expression
Ubiquitous expression in bone marrow (RPKM 16.3), lymph node (RPKM 12.1) and 24 other tissues See more
Orthologs

Genomic context

See MIS18BP1 in Genome Data Viewer
Location:
14q21.2
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (45203190..45257190, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (45672393..45722714, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene pre-mRNA processing factor 39 Neighboring gene FKBP prolyl isomerase 3 Neighboring gene FA complementation group M Neighboring gene uncharacterized LOC107984674 Neighboring gene RNA, U6 small nuclear 552, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11186, KIAA1903

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
CENP-A containing nucleosome assembly TAS
Traceable Author Statement
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
condensed nuclear chromosome kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
mis18-binding protein 1
Names
P243
hsKNL-2
kinetochore null 2 homolog
kinetochore-associated protein KNL-2 homolog
putative protein p243 which interacts with transcription factor Sp1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018353.5NP_060823.3  mis18-binding protein 1

    See identical proteins and their annotated locations for NP_060823.3

    Status: VALIDATED

    Source sequence(s)
    AB067490, AW971491, BC065544
    Consensus CDS
    CCDS9684.1
    UniProtKB/Swiss-Prot
    Q6P0N0
    Related
    ENSP00000309790.4, ENST00000310806.8
    Conserved Domains (3) summary
    smart00717
    Location:878927
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:879925
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam09133
    Location:385472
    SANTA; SANTA (SANT Associated)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    45203190..45257190 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267833.5XP_005267890.1  mis18-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005267890.1

    UniProtKB/Swiss-Prot
    Q6P0N0
    Conserved Domains (3) summary
    smart00717
    Location:878927
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:879925
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam09133
    Location:385472
    SANTA; SANTA (SANT Associated)
  2. XM_017021425.1XP_016876914.1  mis18-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6P0N0
    Conserved Domains (3) summary
    smart00717
    Location:878927
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:879925
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam09133
    Location:385472
    SANTA; SANTA (SANT Associated)
  3. XM_011536923.1XP_011535225.1  mis18-binding protein 1 isoform X2

    Conserved Domains (3) summary
    smart00717
    Location:490539
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:491537
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam09133
    Location:184
    SANTA; SANTA (SANT Associated)

RNA

  1. XR_002957559.1 RNA Sequence

  2. XR_001750406.2 RNA Sequence

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