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    Zfp598 zinc finger protein 598 [ Mus musculus (house mouse) ]

    Gene ID: 213753, updated on 8-Aug-2021

    Summary

    Official Symbol
    Zfp598provided by MGI
    Official Full Name
    zinc finger protein 598provided by MGI
    Primary source
    MGI:MGI:2670965
    See related
    Ensembl:ENSMUSG00000041130
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ntrap; Znf598; BC023040
    Expression
    Ubiquitous expression in colon adult (RPKM 52.8), ovary adult (RPKM 51.1) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Zfp598 in Genome Data Viewer
    Location:
    17; 17 A3.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24888661..24900997)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24669687..24682023)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (24806697..24818961)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 Neighboring gene neuropeptide W Neighboring gene synaptogyrin 3 Neighboring gene growth factor, augmenter of liver regeneration Neighboring gene NADPH oxidase organizer 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase ZNF598
    NP_001335160.1
    NP_898972.1
    XP_006524063.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348231.1NP_001335160.1  E3 ubiquitin-protein ligase ZNF598 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC154566, BC050859, BQ180106, CF537189
      Consensus CDS
      CCDS89013.1
      UniProtKB/Swiss-Prot
      Q80YR4
      Related
      ENSMUSP00000038367.7, ENSMUST00000047179.7
      Conserved Domains (2) summary
      COG5236
      Location:27336
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      cl26464
      Location:366675
      Atrophin-1; Atrophin-1 family
    2. NM_183149.2NP_898972.1  E3 ubiquitin-protein ligase ZNF598 isoform 1

      See identical proteins and their annotated locations for NP_898972.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC154566, BC050859, CF537189
      Consensus CDS
      CCDS28490.1
      UniProtKB/Swiss-Prot
      Q80YR4
      Related
      ENSMUSP00000157172.2, ENSMUST00000234956.2
      Conserved Domains (1) summary
      COG5236
      Location:27326
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24888661..24900997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524000.1XP_006524063.1  E3 ubiquitin-protein ligase ZNF598 isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:198507
      PHA03247; large tegument protein UL36; Provisional
      COG5236
      Location:11155
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
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