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ZNF598 zinc finger protein 598, E3 ubiquitin ligase [ Homo sapiens (human) ]

Gene ID: 90850, updated on 24-May-2020

Summary

Official Symbol
ZNF598provided by HGNC
Official Full Name
zinc finger protein 598, E3 ubiquitin ligaseprovided by HGNC
Primary source
HGNC:HGNC:28079
See related
Ensembl:ENSG00000167962 MIM:617508
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEL2
Summary
Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This protein and Grb10-interacting GYF protein 2 have been identified as a components of the mammalian 4EHP (m4EHP) complex. The complex is thought to function as a translation repressor in embryonic development. [provided by RefSeq, Oct 2012]
Expression
Ubiquitous expression in testis (RPKM 7.9), spleen (RPKM 7.8) and 25 other tissues See more
Orthologs

Genomic context

See ZNF598 in Genome Data Viewer
Location:
16p13.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (1997654..2009821, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2047653..2059822, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene growth factor, augmenter of liver regeneration Neighboring gene synaptogyrin 3 Neighboring gene RNA, 7SL, cytoplasmic 219, pseudogene Neighboring gene neuropeptide W

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human zinc finger protein 598 (ZNF598) at amino acid residues 343-344 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00086, DKFZp762F135

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
protein monoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
rescue of stalled ribosome IDA
Inferred from Direct Assay
more info
PubMed 
rescue of stalled ribosome IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase ZNF598
Names
zinc finger protein 598
NP_835461.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032989.1 RefSeqGene

    Range
    5001..17166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_178167.4NP_835461.2  E3 ubiquitin-protein ligase ZNF598

    See identical proteins and their annotated locations for NP_835461.2

    Status: REVIEWED

    Source sequence(s)
    AC005606, BC041015, BC050477, CA309611
    UniProtKB/Swiss-Prot
    Q86UK7
    Related
    ENSP00000455882.1, ENST00000563630.6
    Conserved Domains (1) summary
    pfam15697
    Location:364440
    DUF4666; Domain of unknown function (DUF4666)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    1997654..2009821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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