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    Dennd6a DENN/MADD domain containing 6A [ Mus musculus (house mouse) ]

    Gene ID: 211922, updated on 23-Jun-2021

    Summary

    Official Symbol
    Dennd6aprovided by MGI
    Official Full Name
    DENN/MADD domain containing 6Aprovided by MGI
    Primary source
    MGI:MGI:2442980
    See related
    Ensembl:ENSMUSG00000040818
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam11; Fam116a
    Expression
    Ubiquitous expression in placenta adult (RPKM 4.7), bladder adult (RPKM 4.3) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Dennd6a in Genome Data Viewer
    Location:
    14; 14 A3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (26295013..26355477)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (26573858..26634322)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (27399036..27451586)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene Kruppel-like factor 17 pseudogene Neighboring gene ribosomal protein S8 pseudogene Neighboring gene ADP-ribosylation factor 4 Neighboring gene phosphodiesterase 12 Neighboring gene microRNA 7672

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC38041, mFLJ00229, A630054L15Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of cell-cell adhesion mediated by cadherin ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein DENND6A
    Names
    DENN domain-containing protein 6A
    family with sequence similarity 116, member A
    protein FAM116A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134465.2NP_001127937.1  protein DENND6A isoform a

      See identical proteins and their annotated locations for NP_001127937.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC121919, AK054295, AK131163
      Consensus CDS
      CCDS49430.1
      UniProtKB/Swiss-Prot
      Q8BH65
      Related
      ENSMUSP00000039361.8, ENSMUST00000037585.9
      Conserved Domains (2) summary
      pfam08616
      Location:267370
      SPA; Stabilization of polarity axis
      cl11519
      Location:168356
      DENN; DENN (AEX-3) domain
    2. NM_001285466.1NP_001272395.1  protein DENND6A isoform c

      See identical proteins and their annotated locations for NP_001272395.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks several exons, uses an alternate 5'-terminal exon, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform.
      Source sequence(s)
      AC121919, AK033036, AK131163
      Consensus CDS
      CCDS88601.1
      UniProtKB/Swiss-Prot
      Q8BH65
      Related
      ENSMUSP00000152966.2, ENSMUST00000224248.2
      Conserved Domains (1) summary
      cl40631
      Location:43146
      SPA; Stabilization of polarity axis
    3. NM_001285467.1NP_001272396.1  protein DENND6A isoform c

      See identical proteins and their annotated locations for NP_001272396.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 5'-terminal exon, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform.
      Source sequence(s)
      AC121919, AK131163, AK135953, AK163396
      Consensus CDS
      CCDS88601.1
      UniProtKB/Swiss-Prot
      Q8BH65
      Related
      ENSMUSP00000153187.2, ENSMUST00000224111.2
      Conserved Domains (1) summary
      cl40631
      Location:43146
      SPA; Stabilization of polarity axis
    4. NM_145969.4NP_666081.1  protein DENND6A isoform b

      See identical proteins and their annotated locations for NP_666081.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC132111, AK054295, AK131163, AK161908
      Consensus CDS
      CCDS84101.1
      UniProtKB/Swiss-Prot
      Q8BH65
      Related
      ENSMUSP00000144906.2, ENSMUST00000203874.3
      Conserved Domains (2) summary
      pfam08616
      Location:267370
      SPA; Stabilization of polarity axis
      cl11519
      Location:168356
      DENN; DENN (AEX-3) domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      26295013..26355477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158533.1XP_036014426.1  protein DENND6A isoform X1

      Conserved Domains (1) summary
      cl40631
      Location:43146
      SPA; Stabilization of polarity axis
    2. XM_006518778.1XP_006518841.1  protein DENND6A isoform X1

      See identical proteins and their annotated locations for XP_006518841.1

      UniProtKB/Swiss-Prot
      Q8BH65
      Conserved Domains (1) summary
      cl40631
      Location:43146
      SPA; Stabilization of polarity axis
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