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DENND6A DENN domain containing 6A [ Homo sapiens (human) ]

Gene ID: 201627, updated on 24-Nov-2020

Summary

Official Symbol
DENND6Aprovided by HGNC
Official Full Name
DENN domain containing 6Aprovided by HGNC
Primary source
HGNC:HGNC:26635
See related
Ensembl:ENSG00000174839
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AFI1A; FAM116A
Expression
Ubiquitous expression in ovary (RPKM 8.9), thyroid (RPKM 8.0) and 25 other tissues See more
Orthologs

Genomic context

See DENND6A in Genome Data Viewer
Location:
3p14.3
Exon count:
22
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (57625454..57693118, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (57611181..57678816, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 12 Neighboring gene ARF4 antisense RNA 1 Neighboring gene RNA, U6atac small nuclear 26, pseudogene Neighboring gene DENND6A divergent transcript Neighboring gene sarcolemma associated protein Neighboring gene PDHA1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34969

Gene Ontology Provided by GOA

Function Evidence Code Pubs
guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
positive regulation of cell-cell adhesion mediated by cadherin IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein DENND6A
Names
DENN domain-containing protein 6A
DENN/MADD domain containing 6A
family with sequence similarity 116, member A
protein FAM116A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152678.3NP_689891.1  protein DENND6A

    See identical proteins and their annotated locations for NP_689891.1

    Status: VALIDATED

    Source sequence(s)
    AA605125, AC114480, AK074156, BC040291
    Consensus CDS
    CCDS33773.1
    UniProtKB/Swiss-Prot
    Q8IWF6
    Related
    ENSP00000311401.5, ENST00000311128.10
    Conserved Domains (3) summary
    pfam08616
    Location:270373
    SPA; Stabilization of polarity axis
    cl11519
    Location:171359
    DENN; DENN (AEX-3) domain
    cl26605
    Location:64201
    Avl9; Transport protein Avl9

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    57625454..57693118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713019.3XP_006713082.1  protein DENND6A isoform X1

    Conserved Domains (2) summary
    pfam08616
    Location:269372
    SPA; Stabilization of polarity axis
    cl11519
    Location:170358
    DENN; DENN (AEX-3) domain
  2. XM_017005864.1XP_016861353.1  protein DENND6A isoform X3

  3. XM_006713020.2XP_006713083.1  protein DENND6A isoform X2

    See identical proteins and their annotated locations for XP_006713083.1

    Conserved Domains (2) summary
    pfam08616
    Location:204307
    SPA; Stabilization of polarity axis
    cl11519
    Location:105293
    DENN; DENN (AEX-3) domain

RNA

  1. XR_245100.1 RNA Sequence

  2. XR_001740057.2 RNA Sequence

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