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    Taf3 TATA-box binding protein associated factor 3 [ Mus musculus (house mouse) ]

    Gene ID: 209361, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Taf3provided by MGI
    Official Full Name
    TATA-box binding protein associated factor 3provided by MGI
    Primary source
    MGI:MGI:2388097
    See related
    Ensembl:ENSMUSG00000025782 AllianceGenome:MGI:2388097
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    140kDa; TAF140; TAFII140; TAFII-140; mTAFII140; 4933439M23Rik
    Summary
    Enables p53 binding activity and transcription regulator inhibitor activity. Involved in negative regulation of DNA-binding transcription factor activity and negative regulation of transcription by RNA polymerase II. Located in male germ cell nucleus. Is expressed in several structures, including eye; genitourinary system; heart; nervous system; and respiratory system. Orthologous to human TAF3 (TATA-box binding protein associated factor 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 3.3), testis adult (RPKM 3.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Taf3 in Genome Data Viewer
    Location:
    2 A1; 2 6.74 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (9919363..10053420, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (9914552..10048609, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 54101 Neighboring gene STARR-seq mESC enhancer starr_03630 Neighboring gene GATA binding protein 3 Neighboring gene GATA binding protein 3 opposite strand Neighboring gene STARR-seq mESC enhancer starr_03633 Neighboring gene Gata3 upstream neighbor Neighboring gene STARR-seq mESC enhancer starr_03634 Neighboring gene predicted gene 13262 Neighboring gene predicted gene, 31290 Neighboring gene predicted gene, 54137 Neighboring gene STARR-positive B cell enhancer ABC_E11119 Neighboring gene ATP synthase F1 subunit gamma Neighboring gene predicted gene, 23608 Neighboring gene Kin17 DNA and RNA binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural insight into the recognition of the H3K4me3 mark by the TFIID subunit TAF3. van Ingen H, et al. Structure, 2008 Aug 6. PMID 18682226
    2. Subnuclear segregation of genes and core promoter factors in myogenesis. Yao J, et al. Genes Dev, 2011 Mar 15. PMID 21357673, Free PMC Article
    3. MyoD targets TAF3/TRF3 to activate myogenin transcription. Deato MD, et al. Mol Cell, 2008 Oct 10. PMID 18851836, Free PMC Article
    4. Switching of the core transcription machinery during myogenesis. Deato MD, et al. Genes Dev, 2007 Sep 1. PMID 17704303, Free PMC Article
    5. Control of embryonic stem cell lineage commitment by core promoter factor, TAF3. Liu Z, et al. Cell, 2011 Sep 2. PMID 21884934, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that TATA box binding protein-associated factor TAF3 as a direct target of nuclear phosphoinositides (PI).
      Title: The basal transcription complex component TAF3 transduces changes in nuclear phosphoinositides into transcriptional output.
    2. Study shows that this TAF3 activity is critical for early lineage segregation during stem cell differentiation.
      Title: Control of embryonic stem cell lineage commitment by core promoter factor, TAF3.
    3. In vitro and cell-based assays identify a domain of TAF3 that mediates coactivator functions targeted by MyoD.
      Title: MyoD targets TAF3/TRF3 to activate myogenin transcription.
    4. Results report the solution structure of the TAF3-PHD finger and its complex with an H3K4me3 peptide.
      Title: Structural insight into the recognition of the H3K4me3 mark by the TFIID subunit TAF3.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables p53 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables p53 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription regulator inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in maintenance of protein location in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of protein location in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription initiation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription initiation by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of transcription factor TFIID complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transcription initiation factor TFIID subunit 3
    Names
    140 kDa TATA box-binding protein-associated factor
    RNA polymerase II transcription factor, TFIID subunit
    TAF(II)140
    TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
    TBP-associated factor 3
    transcription initiation factor TFIID 140 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027748.3 → NP_082024.2  transcription initiation factor TFIID subunit 3

      See identical proteins and their annotated locations for NP_082024.2

      Status: VALIDATED

      Source sequence(s)
      AK136045, AW049595, BB621106, BC137618, CX763644
      Consensus CDS
      CCDS15675.1
      UniProtKB/Swiss-Prot
      Q3U490, Q3UWX2, Q5HZG4, Q8BIU8, Q99JH4
      UniProtKB/TrEMBL
      A2ASY0, A2ASY1
      Related
      ENSMUSP00000026888.5, ENSMUST00000026888.11
      Conserved Domains (3) summary
      smart00576
      Location:5 → 79
      BTP; Bromodomain transcription factors and PHD domain containing proteins
      cd15522
      Location:869 → 914
      PHD_TAF3; PHD finger found in transcription initiation factor TFIID subunit 3 (TAF3)
      pfam16294
      Location:607 → 656
      RSB_motif; RNSP1-SAP18 binding (RSB) motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      9919363..10053420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5HZG4.2 GenPept UniProtKB/Swiss-Prot:Q5HZG4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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