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TAF3 TATA-box binding protein associated factor 3 [ Homo sapiens (human) ]

Gene ID: 83860, updated on 7-Jul-2019

Summary

Official Symbol
TAF3provided by HGNC
Official Full Name
TATA-box binding protein associated factor 3provided by HGNC
Primary source
HGNC:HGNC:17303
See related
Ensembl:ENSG00000165632 MIM:606576
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAF140; TAFII140; TAFII-140
Summary
The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors (Gangloff et al., 2001 [PubMed 11438666]).[supplied by OMIM, May 2009]
Expression
Ubiquitous expression in testis (RPKM 5.8), ovary (RPKM 3.8) and 25 other tissues See more
Orthologs

Genomic context

See TAF3 in Genome Data Viewer
Location:
10p14
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (7818505..8016631)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (7860467..8057016)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Kin17 DNA and RNA binding protein Neighboring gene uncharacterized LOC105376392 Neighboring gene ATP synthase F1 subunit gamma Neighboring gene uncharacterized LOC105376394 Neighboring gene GATA3 antisense RNA 1 Neighboring gene GATA binding protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR PubMed
tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed
tat HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter PubMed
tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed
tat TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC25063

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
p53 binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription initiation factor TFIID subunit 3
Names
140 kDa TATA box-binding protein-associated factor
RNA polymerase II transcription factor TAFII140
TAF(II)140
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
TBP-associated factor 3
transcription initiation factor TFIID 140 kDa subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031923.4NP_114129.1  transcription initiation factor TFIID subunit 3

    See identical proteins and their annotated locations for NP_114129.1

    Status: VALIDATED

    Source sequence(s)
    AL159172, AL353754, AL390294
    Consensus CDS
    CCDS41487.1
    UniProtKB/Swiss-Prot
    Q5VWG9
    Related
    ENSP00000340271.5, ENST00000344293.6
    Conserved Domains (2) summary
    smart00576
    Location:579
    BTP; Bromodomain transcription factors and PHD domain containing proteins
    cd15522
    Location:867912
    PHD_TAF3; PHD finger found in transcription initiation factor TFIID subunit 3 (TAF3)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    7818505..8016631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519741.2XP_011518043.2  transcription initiation factor TFIID subunit 3 isoform X1

    Conserved Domains (4) summary
    smart00576
    Location:579
    BTP; Bromodomain transcription factors and PHD domain containing proteins
    cd15522
    Location:866911
    PHD_TAF3; PHD finger found in transcription initiation factor TFIID subunit 3 (TAF3)
    cl25751
    Location:228387
    DUF4045; Domain of unknown function (DUF4045)
    cl26386
    Location:776846
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
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