Format

Send to:

Choose Destination
    • Showing Current items.

    Snap23 synaptosomal-associated protein 23 [ Mus musculus (house mouse) ]

    Gene ID: 20619, updated on 14-Sep-2021

    Summary

    Official Symbol
    Snap23provided by MGI
    Official Full Name
    synaptosomal-associated protein 23provided by MGI
    Primary source
    MGI:MGI:109356
    See related
    Ensembl:ENSMUSG00000027287
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sn; SNA; Sndt; Synd; 23kDa; Syndet; SNAP-23; AA408749
    Expression
    Broad expression in placenta adult (RPKM 10.3), bladder adult (RPKM 8.3) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Snap23 in Genome Data Viewer
    Location:
    2 60.37 cM; 2 E5
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120398137..120431885)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (120567655..120601255)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (120393407..120426458)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4931402G19 gene Neighboring gene calpain 3 Neighboring gene zinc finger protein 106 Neighboring gene leucine rich repeat containing 57 Neighboring gene HAUS augmin-like complex, subunit 2 Neighboring gene START domain containing 9 Neighboring gene congenital dyserythropoietic anemia, type I (human)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables SNAP receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histamine secretion by mast cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle-mediated transport in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SNARE complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in azurophil granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in specific granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    synaptosomal-associated protein 23
    Names
    synaptosomal-associated protein, 23kD
    vesicle-membrane fusion protein SNAP-23

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177792.1NP_001171263.1  synaptosomal-associated protein 23 isoform a

      See identical proteins and their annotated locations for NP_001171263.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longer protein (isoform a).
      Source sequence(s)
      AK017311, AK019162
      Consensus CDS
      CCDS50681.1
      UniProtKB/Swiss-Prot
      O09044
      UniProtKB/TrEMBL
      Q9D3L3
      Related
      ENSMUSP00000112138.2, ENSMUST00000116437.8
      Conserved Domains (3) summary
      cd15884
      Location:159217
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:975
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:100157
      SNAP-25; SNAP-25 family
    2. NM_001177793.1NP_001171264.1  synaptosomal-associated protein 23 isoform b

      See identical proteins and their annotated locations for NP_001171264.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a different splice site in the 5' UTR and lacks an alternate, in-frame, coding exon, compared to variant 1. Variants 2 and 3 encode the same protein (isoform b).
      Source sequence(s)
      AK019162, BC070456
      Consensus CDS
      CCDS16622.1
      UniProtKB/Swiss-Prot
      O09044
      UniProtKB/TrEMBL
      A2AKH4
      Related
      ENSMUSP00000028743.4, ENSMUST00000028743.10
      Conserved Domains (3) summary
      cd15884
      Location:148206
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:975
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:86146
      SNAP-25; SNAP-25 family
    3. NM_009222.3NP_033248.1  synaptosomal-associated protein 23 isoform b

      See identical proteins and their annotated locations for NP_033248.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate, in-frame, exon, compared to variant 1. Variants 2 and 3 encode the same protein (isoform b).
      Source sequence(s)
      AK019162
      Consensus CDS
      CCDS16622.1
      UniProtKB/Swiss-Prot
      O09044
      UniProtKB/TrEMBL
      A2AKH4
      Related
      ENSMUSP00000106339.3, ENSMUST00000110711.9
      Conserved Domains (3) summary
      cd15884
      Location:148206
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:975
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:86146
      SNAP-25; SNAP-25 family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      120398137..120431885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499056.5XP_006499119.1  synaptosomal-associated protein 23 isoform X1

      See identical proteins and their annotated locations for XP_006499119.1

      UniProtKB/TrEMBL
      Q9D3L3
      Conserved Domains (3) summary
      cd15884
      Location:159217
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:975
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:100157
      SNAP-25; SNAP-25 family
    2. XM_006499054.5XP_006499117.1  synaptosomal-associated protein 23 isoform X1

      See identical proteins and their annotated locations for XP_006499117.1

      UniProtKB/TrEMBL
      Q9D3L3
      Conserved Domains (3) summary
      cd15884
      Location:159217
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:975
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:100157
      SNAP-25; SNAP-25 family
    3. XM_006499057.5XP_006499120.1  synaptosomal-associated protein 23 isoform X2

      See identical proteins and their annotated locations for XP_006499120.1

      UniProtKB/Swiss-Prot
      O09044
      UniProtKB/TrEMBL
      A2AKH4
      Conserved Domains (3) summary
      cd15884
      Location:148206
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:975
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:86146
      SNAP-25; SNAP-25 family
    Support Center