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SNAP23 synaptosome associated protein 23 [ Homo sapiens (human) ]

Gene ID: 8773, updated on 13-Mar-2020

Summary

Official Symbol
SNAP23provided by HGNC
Official Full Name
synaptosome associated protein 23provided by HGNC
Primary source
HGNC:HGNC:11131
See related
Ensembl:ENSG00000092531 MIM:602534
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNAP-23; SNAP23A; SNAP23B; HsT17016
Summary
Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 25.6), appendix (RPKM 23.5) and 25 other tissues See more
Orthologs

Genomic context

See SNAP23 in Genome Data Viewer
Location:
15q15.1-q15.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (42491244..42533061)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42783442..42825259)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene calpain 3 Neighboring gene uncharacterized LOC105370794 Neighboring gene zinc finger protein 106 Neighboring gene RNA, U6 small nuclear 188, pseudogene Neighboring gene leucine rich repeat containing 57 Neighboring gene HAUS augmin like complex subunit 2 Neighboring gene myosin light chain 12B pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
syntaxin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
Traceable Author Statement
more info
 
exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histamine secretion by mast cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane fusion TAS
Traceable Author Statement
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
post-Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle priming IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle targeting TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE complex IDA
Inferred from Direct Assay
more info
PubMed 
adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
azurophil granule IDA
Inferred from Direct Assay
more info
PubMed 
cell IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
mast cell granule IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
phagocytic vesicle membrane TAS
Traceable Author Statement
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
presynapse IEA
Inferred from Electronic Annotation
more info
 
specific granule IDA
Inferred from Direct Assay
more info
PubMed 
specific granule membrane TAS
Traceable Author Statement
more info
 
tertiary granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
synaptosomal-associated protein 23
Names
synaptosomal-associated protein, 23kD
synaptosomal-associated protein, 23kDa
synaptosome associated protein 23kDa
vesicle-membrane fusion protein SNAP-23

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003825.4NP_003816.2  synaptosomal-associated protein 23 isoform SNAP23A

    See identical proteins and their annotated locations for NP_003816.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript, containing eight exons and encoding the full-length isoform (SNAP23A).
    Source sequence(s)
    AK290152, BC022890, BM782600
    Consensus CDS
    CCDS10087.1
    UniProtKB/Swiss-Prot
    O00161
    UniProtKB/TrEMBL
    A8K287
    Related
    ENSP00000249647.3, ENST00000249647.8
    Conserved Domains (3) summary
    cd15884
    Location:149207
    SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
    cd15895
    Location:975
    SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
    pfam00835
    Location:86147
    SNAP-25; SNAP-25 family
  2. NM_130798.2NP_570710.1  synaptosomal-associated protein 23 isoform SNAP23B

    See identical proteins and their annotated locations for NP_570710.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks internal exon 6 but maintains the same reading frame as compared to transcript variant 1. It encodes an isoform (SNAP23B) which is missing 53 aa as compared to the full-length isoform (SNAP23A) encoded by transcript variant 1. The missing region is required for nonspecific binding of the protein to plasma membranes, indicating a functional difference between isoforms SNAP23A and SNAP23B.
    Source sequence(s)
    AK290152, BC022890, BM782600, DA650133, DA882401
    Consensus CDS
    CCDS10088.1
    UniProtKB/Swiss-Prot
    O00161
    UniProtKB/TrEMBL
    A0A024R9R8, A8K287
    Related
    ENSP00000207062.1, ENST00000349777.5
    Conserved Domains (2) summary
    cd15884
    Location:96154
    SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
    cl22856
    Location:975
    SNARE; SNARE motif

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    42491244..42533061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022694.1XP_016878183.1  synaptosomal-associated protein 23 isoform X3

  2. XM_006720725.3XP_006720788.1  synaptosomal-associated protein 23 isoform X2

    See identical proteins and their annotated locations for XP_006720788.1

    Conserved Domains (3) summary
    cd15884
    Location:160218
    SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
    cd15895
    Location:975
    SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
    pfam00835
    Location:100158
    SNAP-25; SNAP-25 family
  3. XM_017022692.2XP_016878181.1  synaptosomal-associated protein 23 isoform X1

  4. XM_017022693.2XP_016878182.1  synaptosomal-associated protein 23 isoform X3

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