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    TCTE1 t-complex-associated-testis-expressed 1 [ Homo sapiens (human) ]

    Gene ID: 202500, updated on 5-Mar-2024

    Summary

    Official Symbol
    TCTE1provided by HGNC
    Official Full Name
    t-complex-associated-testis-expressed 1provided by HGNC
    Primary source
    HGNC:HGNC:11693
    See related
    Ensembl:ENSG00000146221 MIM:186975; AllianceGenome:HGNC:11693
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DRC5; D6S46; FAP155
    Summary
    Predicted to be involved in flagellated sperm motility. Predicted to be located in sperm flagellum. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis (RPKM 12.5) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TCTE1 in Genome Data Viewer
    Location:
    6p21.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (44278734..44297698, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (44112859..44131845, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (44246471..44265435, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA polymerase I and III subunit C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44222709-44223424 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:44224854-44225567 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24635 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24636 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24637 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44232415-44232914 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44243146-44243938 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17263 Neighboring gene uncharacterized LOC124901322 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:44280829-44281388 Neighboring gene solute carrier family 35 member B2 Neighboring gene microRNA 4647 Neighboring gene transmembrane protein 151B Neighboring gene NFKB inhibitor epsilon Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91950 Neighboring gene alanyl-tRNA synthetase 2, mitochondrial Neighboring gene spermatogenesis associated serine rich 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    General gene information

    Clone Names

    • FLJ50041, MGC33600

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    dynein regulatory complex subunit 5
    Names
    T-complex-associated testis-expressed protein 1
    tcte-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182539.4NP_872345.2  dynein regulatory complex subunit 5

      See identical proteins and their annotated locations for NP_872345.2

      Status: VALIDATED

      Source sequence(s)
      AA732744, AK301825, AL353588
      Consensus CDS
      CCDS4910.1
      UniProtKB/Swiss-Prot
      B4DX59, Q5JU00, Q8IYS6
      Related
      ENSP00000360560.4, ENST00000371505.5
      Conserved Domains (2) summary
      cd00116
      Location:179489
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:309335
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      44278734..44297698 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418273.1XP_047274229.1  dynein regulatory complex subunit 5 isoform X1

      UniProtKB/Swiss-Prot
      B4DX59, Q5JU00, Q8IYS6
    2. XM_005248873.3XP_005248930.1  dynein regulatory complex subunit 5 isoform X2

      Conserved Domains (1) summary
      cl39015
      Location:179402
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    3. XM_005248872.2XP_005248929.1  dynein regulatory complex subunit 5 isoform X1

      See identical proteins and their annotated locations for XP_005248929.1

      UniProtKB/Swiss-Prot
      B4DX59, Q5JU00, Q8IYS6
      Conserved Domains (2) summary
      cd00116
      Location:179489
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:309335
      LRR_RI; leucine-rich repeat [structural motif]
    4. XM_047418272.1XP_047274228.1  dynein regulatory complex subunit 5 isoform X1

      UniProtKB/Swiss-Prot
      B4DX59, Q5JU00, Q8IYS6
    5. XM_011514338.3XP_011512640.1  dynein regulatory complex subunit 5 isoform X1

      See identical proteins and their annotated locations for XP_011512640.1

      UniProtKB/Swiss-Prot
      B4DX59, Q5JU00, Q8IYS6
      Conserved Domains (2) summary
      cd00116
      Location:179489
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:309335
      LRR_RI; leucine-rich repeat [structural motif]
    6. XM_006715009.4XP_006715072.1  dynein regulatory complex subunit 5 isoform X3

      See identical proteins and their annotated locations for XP_006715072.1

      Conserved Domains (2) summary
      cd00116
      Location:80390
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:210236
      LRR_RI; leucine-rich repeat [structural motif]
    7. XM_005248874.3XP_005248931.1  dynein regulatory complex subunit 5 isoform X3

      See identical proteins and their annotated locations for XP_005248931.1

      Conserved Domains (2) summary
      cd00116
      Location:80390
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:210236
      LRR_RI; leucine-rich repeat [structural motif]
    8. XM_011514339.3XP_011512641.1  dynein regulatory complex subunit 5 isoform X3

      See identical proteins and their annotated locations for XP_011512641.1

      Conserved Domains (2) summary
      cd00116
      Location:80390
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:210236
      LRR_RI; leucine-rich repeat [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      44112859..44131845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354439.1XP_054210414.1  dynein regulatory complex subunit 5 isoform X2

    2. XM_054354436.1XP_054210411.1  dynein regulatory complex subunit 5 isoform X1

    3. XM_054354438.1XP_054210413.1  dynein regulatory complex subunit 5 isoform X1

    4. XM_054354437.1XP_054210412.1  dynein regulatory complex subunit 5 isoform X1

    5. XM_054354442.1XP_054210417.1  dynein regulatory complex subunit 5 isoform X3

    6. XM_054354440.1XP_054210415.1  dynein regulatory complex subunit 5 isoform X3

    7. XM_054354441.1XP_054210416.1  dynein regulatory complex subunit 5 isoform X3