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    Rnf185 ring finger protein 185 [ Mus musculus (house mouse) ]

    Gene ID: 193670, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rnf185provided by MGI
    Official Full Name
    ring finger protein 185provided by MGI
    Primary source
    MGI:MGI:1922078
    See related
    Ensembl:ENSMUSG00000020448
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in testis adult (RPKM 16.3), kidney adult (RPKM 15.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rnf185 in Genome Data Viewer
    Location:
    11; 11 A1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3365973..3402956, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3415973..3452956, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (3315986..3352328, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12592 Neighboring gene phosphoinositide-3-kinase interacting protein 1 Neighboring gene LIM motif-containing protein kinase 2 Neighboring gene predicted gene, 51879 Neighboring gene RIKEN cDNA 8430429K09 gene Neighboring gene predicted gene, 53661 Neighboring gene 39S ribosomal protein L30, mitochondrial pseudogene Neighboring gene phospholipase A2, group III Neighboring gene inositol polyphosphate 5-phosphatase J

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC19394, 1700022N24Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-like protein conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin-like protein conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ER-associated misfolded protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF185
    Names
    RING-type E3 ubiquitin transferase RNF185
    NP_001277401.1
    NP_001277402.1
    NP_663330.2
    XP_006514657.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290472.1NP_001277401.1  E3 ubiquitin-protein ligase RNF185 isoform 2

      See identical proteins and their annotated locations for NP_001277401.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks part of the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK034108, AK075756, AL713875, AV347010
      Consensus CDS
      CCDS70127.1
      UniProtKB/Swiss-Prot
      Q91YT2
      Related
      ENSMUSP00000076333.6, ENSMUST00000077078.12
      Conserved Domains (1) summary
      cd00162
      Location:3883
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    2. NM_001290473.1NP_001277402.1  E3 ubiquitin-protein ligase RNF185 isoform 3

      See identical proteins and their annotated locations for NP_001277402.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK034108, AK075756, AL713875, AV347010
      UniProtKB/Swiss-Prot
      Q91YT2
      Conserved Domains (2) summary
      PLN03208
      Location:2965
      PLN03208; E3 ubiquitin-protein ligase RMA2; Provisional
      cl17238
      Location:833
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    3. NM_145355.5NP_663330.2  E3 ubiquitin-protein ligase RNF185 isoform 1

      See identical proteins and their annotated locations for NP_663330.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK034108, AK075756, AL713875, AV347010
      Consensus CDS
      CCDS24361.1
      UniProtKB/Swiss-Prot
      Q91YT2
      Related
      ENSMUSP00000067053.3, ENSMUST00000064364.3
      Conserved Domains (1) summary
      cd00162
      Location:74119
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RNA

    1. NR_110959.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two consecutive internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AK034108, AK075756, AL713875, AV347010

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      3365973..3402956 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514594.5XP_006514657.1  E3 ubiquitin-protein ligase RNF185 isoform X1

      See identical proteins and their annotated locations for XP_006514657.1

      Conserved Domains (2) summary
      PLN03208
      Location:2965
      PLN03208; E3 ubiquitin-protein ligase RMA2; Provisional
      cl17238
      Location:833
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
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