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    Ptpra protein tyrosine phosphatase, receptor type, A [ Mus musculus (house mouse) ]

    Gene ID: 19262, updated on 5-Sep-2021

    Summary

    Official Symbol
    Ptpraprovided by MGI
    Official Full Name
    protein tyrosine phosphatase, receptor type, Aprovided by MGI
    Primary source
    MGI:MGI:97808
    See related
    Ensembl:ENSMUSG00000027303
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P; PT; RP; PTP; Ptpa; Rptra; Ptpalpha; Rptpalpha; Rptralpha
    Expression
    Ubiquitous expression in ovary adult (RPKM 35.2), CNS E18 (RPKM 33.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ptpra in Genome Data Viewer
    Location:
    2 F1; 2 63.23 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (130292198..130396220)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (130450278..130554300)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (130276014..130380036)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene transmembrane 239 Neighboring gene PC-esterase domain containing 1A Neighboring gene VSP16 CORVET/HOPS core subunit Neighboring gene predicted gene, 52562 Neighboring gene VISTA enhancer mm1313 Neighboring gene RIKEN cDNA 4930473A02 gene Neighboring gene mitochondrial ribosomal protein S26 Neighboring gene oxytocin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC118095

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of synaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    receptor-type tyrosine-protein phosphatase alpha
    Names
    LCA-related phosphatase
    PTPTY-28
    R-PTP-alpha
    protein-tyrosine phosphatase alpha
    NP_001157160.1
    NP_001342090.1
    NP_033006.2
    XP_036015592.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163688.1NP_001157160.1  receptor-type tyrosine-protein phosphatase alpha isoform 2 precursor

      See identical proteins and their annotated locations for NP_001157160.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK010458, AK031690, AK162387
      Consensus CDS
      CCDS50712.1
      UniProtKB/TrEMBL
      Q3TRY9, Q91V35
      Related
      ENSMUSP00000028769.7, ENSMUST00000028769.14
      Conserved Domains (3) summary
      smart00194
      Location:523781
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:551781
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam07010
      Location:23170
      Endomucin; Endomucin
    2. NM_001355161.1NP_001342090.1  receptor-type tyrosine-protein phosphatase alpha isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate in-frame exon and lacks another alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL731707, BX890605
      Conserved Domains (3) summary
      smart00194
      Location:240500
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:560790
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cl25495
      Location:17179
      Endomucin; Endomucin
    3. NM_008980.2NP_033006.2  receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

      See identical proteins and their annotated locations for NP_033006.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK010458, AK031690, AK162387, AL731707
      Consensus CDS
      CCDS16743.1
      UniProtKB/Swiss-Prot
      P18052
      UniProtKB/TrEMBL
      Q3TRY9, Q91V35
      Related
      ENSMUSP00000076533.4, ENSMUST00000077303.4
      Conserved Domains (3) summary
      smart00194
      Location:559817
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:587817
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam07010
      Location:23170
      Endomucin; Endomucin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      130292198..130396220
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159699.1XP_036015592.1  receptor-type tyrosine-protein phosphatase alpha isoform X1

      Conserved Domains (2) summary
      cd14621
      Location:250545
      R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
      cd14623
      Location:599826
      R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
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