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PTPRA protein tyrosine phosphatase receptor type A [ Homo sapiens (human) ]

Gene ID: 5786, updated on 1-Jun-2020

Summary

Official Symbol
PTPRAprovided by HGNC
Official Full Name
protein tyrosine phosphatase receptor type Aprovided by HGNC
Primary source
HGNC:HGNC:9664
See related
Ensembl:ENSG00000132670 MIM:176884
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRP; HLPR; PTPA; HEPTP; HPTPA; RPTPA; PTPRL2; HPTPalpha; R-PTP-alpha
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 49.1), thyroid (RPKM 27.1) and 25 other tissues See more
Orthologs

Genomic context

See PTPRA in Genome Data Viewer
Location:
20p13
Exon count:
30
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (2864195..3038669)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (2844841..3019316)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr20.196 Neighboring gene PC-esterase domain containing 1A Neighboring gene VPS16 core subunit of CORVET and HOPS complexes Neighboring gene gonadotropin releasing hormone 2 Neighboring gene mitochondrial ribosomal protein S26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 induces CD4 association with lymphocyte surface molecules CD3, CD11a, CD27, CD45RA, CD45RB, CD45RO, CD49d, CD38, CD26, CD59, CD95 and class I MHC molecules PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
focal adhesion IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of synaptic membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase alpha
Names
Leukocyte common antigen-related peptide (protein tyrosine phosphate)
PTPLCA-related phosphatase
PTPase-alpha
protein tyrosine phosphatase, receptor type, alpha polypeptide
protein-tyrosine phosphatase alpha
tyrosine phosphatase alpha
NP_002827.1
NP_543030.1
NP_543031.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002836.3NP_002827.1  receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

    See identical proteins and their annotated locations for NP_002827.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK090743, BC027308, M34668
    Consensus CDS
    CCDS13038.1
    UniProtKB/Swiss-Prot
    P18433
    Related
    ENSP00000369756.3, ENST00000380393.7
    Conserved Domains (3) summary
    smart00194
    Location:240500
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:560790
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cl25495
    Location:10179
    Endomucin; Endomucin
  2. NM_080840.2NP_543030.1  receptor-type tyrosine-protein phosphatase alpha isoform 2 precursor

    See identical proteins and their annotated locations for NP_543030.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' UTR exon, and lacks an internal coding exon, when compared to variant 1. The resulting isoform (2) lacks a 9 aa internal segment, as compared to isoform 1.
    Source sequence(s)
    AK090743, BC027308, BQ213974
    Consensus CDS
    CCDS13039.1
    UniProtKB/Swiss-Prot
    P18433
    Related
    ENSP00000216877.6, ENST00000216877.10
    Conserved Domains (3) summary
    smart00194
    Location:231491
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:551781
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cl25495
    Location:10170
    Endomucin; Endomucin
  3. NM_080841.2NP_543031.1  receptor-type tyrosine-protein phosphatase alpha isoform 2 precursor

    See identical proteins and their annotated locations for NP_543031.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an additional exon within the 5' UTR, and lacks an internal coding exon, when compared to variant 1. The resulting isoform (2) lacks a 9 aa internal segment, as compared to isoform 1.
    Source sequence(s)
    AK090743, BC027308, X53364
    Consensus CDS
    CCDS13039.1
    UniProtKB/Swiss-Prot
    P18433
    Related
    ENSP00000348468.3, ENST00000356147.3
    Conserved Domains (3) summary
    smart00194
    Location:231491
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:551781
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cl25495
    Location:10170
    Endomucin; Endomucin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    2864195..3038669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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