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PTPRA protein tyrosine phosphatase receptor type A [ Homo sapiens (human) ]

Gene ID: 5786, updated on 8-Jul-2021

Summary

Official Symbol
PTPRAprovided by HGNC
Official Full Name
protein tyrosine phosphatase receptor type Aprovided by HGNC
Primary source
HGNC:HGNC:9664
See related
Ensembl:ENSG00000132670 MIM:176884
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRP; HLPR; PTPA; HEPTP; HPTPA; RPTPA; PTPRL2; HPTPalpha; R-PTP-alpha
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 49.1), thyroid (RPKM 27.1) and 25 other tissues See more
Orthologs
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Genomic context

See PTPRA in Genome Data Viewer
Location:
20p13
Exon count:
34
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (2864184..3038669)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (2844830..3019315)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr20.196 Neighboring gene PC-esterase domain containing 1A Neighboring gene VPS16 core subunit of CORVET and HOPS complexes Neighboring gene gonadotropin releasing hormone 2 Neighboring gene mitochondrial ribosomal protein S26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 induces CD4 association with lymphocyte surface molecules CD3, CD11a, CD27, CD45RA, CD45RB, CD45RO, CD49d, CD38, CD26, CD59, CD95 and class I MHC molecules PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transmembrane receptor protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in integrin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in integral component of synaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase alpha
Names
Leukocyte common antigen-related peptide (protein tyrosine phosphate)
PTPLCA-related phosphatase
PTPase-alpha
protein tyrosine phosphatase, receptor type, alpha polypeptide
protein-tyrosine phosphatase alpha
tyrosine phosphatase alpha
NP_001372231.1
NP_001372232.1
NP_001372233.1
NP_001372234.1
NP_001372235.1
NP_001372236.1
NP_001372237.1
NP_001372239.1
NP_001372240.1
NP_001372241.1
NP_001372242.1
NP_001372243.1
NP_001372244.1
NP_001372245.1
NP_001372246.1
NP_001372247.1
NP_001372248.1
NP_001372249.1
NP_001372250.1
NP_001375249.1
NP_001375250.1
NP_001375251.1
NP_001375252.1
NP_001375253.1
NP_002827.1
NP_543030.1
NP_543031.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385302.1NP_001372231.1  receptor-type tyrosine-protein phosphatase alpha isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    cd14621
    Location:225520
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:574801
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
  2. NM_001385303.1NP_001372232.1  receptor-type tyrosine-protein phosphatase alpha isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    cd14621
    Location:225520
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:574801
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
  3. NM_001385304.1NP_001372233.1  receptor-type tyrosine-protein phosphatase alpha isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    cd14621
    Location:216511
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:565792
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
  4. NM_001385305.1NP_001372234.1  receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Related
    ENSP00000382787.2, ENST00000399903.7
    Conserved Domains (2) summary
    cd14621
    Location:214509
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:563790
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
  5. NM_001385306.1NP_001372235.1  receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    cd14621
    Location:214509
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:563790
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
  6. NM_001385307.1NP_001372236.1  receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    cd14621
    Location:214509
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:563790
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
  7. NM_001385308.1NP_001372237.1  receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    cd14621
    Location:214509
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:563790
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
  8. NM_001385310.1NP_001372239.1  receptor-type tyrosine-protein phosphatase alpha isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    cd14621
    Location:216511
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:565789
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
  9. NM_001385311.1NP_001372240.1  receptor-type tyrosine-protein phosphatase alpha isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    cd14621
    Location:205500
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:554781
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
  10. NM_001385312.1NP_001372241.1  receptor-type tyrosine-protein phosphatase alpha isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    cd14621
    Location:205500
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:554780
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
  11. NM_001385313.1NP_001372242.1  receptor-type tyrosine-protein phosphatase alpha isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    cd14623
    Location:464691
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
    cl28904
    Location:270389
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  12. NM_001385314.1NP_001372243.1  receptor-type tyrosine-protein phosphatase alpha isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    cd14623
    Location:462689
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
    cl28904
    Location:268387
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  13. NM_001385315.1NP_001372244.1  receptor-type tyrosine-protein phosphatase alpha isoform 9 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    cd14623
    Location:453680
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
    cl28904
    Location:259378
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  14. NM_001385316.1NP_001372245.1  receptor-type tyrosine-protein phosphatase alpha isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    cd14621
    Location:99394
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:448675
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
  15. NM_001385317.1NP_001372246.1  receptor-type tyrosine-protein phosphatase alpha isoform 11 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    cd14621
    Location:91386
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:440667
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
  16. NM_001385318.1NP_001372247.1  receptor-type tyrosine-protein phosphatase alpha isoform 12 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    PHA02740
    Location:245348
    PHA02740; protein tyrosine phosphatase; Provisional
    cd14623
    Location:424651
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
  17. NM_001385319.1NP_001372248.1  receptor-type tyrosine-protein phosphatase alpha isoform 13 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    PHA02740
    Location:243346
    PHA02740; protein tyrosine phosphatase; Provisional
    cd14623
    Location:422649
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
  18. NM_001385320.1NP_001372249.1  receptor-type tyrosine-protein phosphatase alpha isoform 13 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    PHA02740
    Location:243346
    PHA02740; protein tyrosine phosphatase; Provisional
    cd14623
    Location:422649
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
  19. NM_001385321.1NP_001372250.1  receptor-type tyrosine-protein phosphatase alpha isoform 14 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    PHA02740
    Location:234337
    PHA02740; protein tyrosine phosphatase; Provisional
    cd14623
    Location:413640
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
  20. NM_001388320.1NP_001375249.1  receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    cd14621
    Location:214509
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:563790
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
  21. NM_001388321.1NP_001375250.1  receptor-type tyrosine-protein phosphatase alpha isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    cd14621
    Location:205500
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:554781
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
  22. NM_001388322.1NP_001375251.1  receptor-type tyrosine-protein phosphatase alpha isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    cd14623
    Location:237464
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
    cl28904
    Location:1183
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  23. NM_001388323.1NP_001375252.1  receptor-type tyrosine-protein phosphatase alpha isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    cd14623
    Location:237464
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
    cl28904
    Location:1183
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  24. NM_001388324.1NP_001375253.1  receptor-type tyrosine-protein phosphatase alpha isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Conserved Domains (2) summary
    cd14623
    Location:237464
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
    cl28904
    Location:1183
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  25. NM_002836.4NP_002827.1  receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

    See identical proteins and their annotated locations for NP_002827.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK090743, AL161656, BC027308, M34668
    Consensus CDS
    CCDS13038.1
    UniProtKB/Swiss-Prot
    P18433
    Conserved Domains (2) summary
    cd14621
    Location:214509
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:563790
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
  26. NM_080840.3NP_543030.1  receptor-type tyrosine-protein phosphatase alpha isoform 2 precursor

    See identical proteins and their annotated locations for NP_543030.1

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Consensus CDS
    CCDS13039.1
    UniProtKB/Swiss-Prot
    P18433
    Related
    ENSP00000216877.6, ENST00000216877.10
    Conserved Domains (2) summary
    cd14621
    Location:205500
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:554781
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2
  27. NM_080841.3NP_543031.1  receptor-type tyrosine-protein phosphatase alpha isoform 2 precursor

    See identical proteins and their annotated locations for NP_543031.1

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656
    Consensus CDS
    CCDS13039.1
    UniProtKB/Swiss-Prot
    P18433
    Related
    ENSP00000314568.5, ENST00000318266.9
    Conserved Domains (2) summary
    cd14621
    Location:205500
    R-PTPc-A-1; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1
    cd14623
    Location:554781
    R-PTPc-A-2; catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2

RNA

  1. NR_170936.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL121905, AL161656

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    2864184..3038669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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